2-己基硫基-3-甲基吡嗪 | 73972-65-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: 2-己基硫基-3-甲基吡嗪
• 英文名称: 2-(Hexylthio)-3-methylpyrazine
• 英文别名: 2-hexylsulfanyl-3-methylpyrazine
• CAS: 73972-65-3
• 化学式: C₁₁H₁₈N₂S
• 分子量: 210.34
• InChiKey: DOLQRCIPELCOAZ-UHFFFAOYSA-N

物化性质

• 沸点：
  301.6±42.0 °C(Predicted)
• 密度：
  1.02±0.1 g/cm3(Predicted)
• LogP：
  4.246 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  51.1
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Prodrugs of quinuclidine ring-containing muscarinic agonists and compositions and methods thereof
  申请人：Lenz Therapeutics, Inc.

  公开号：US11214569B2

  公开（公告）日：2022-01-04

  The present invention is directed to compounds of the formula and salts or esters thereof. The present invention is further directed to ophthalmological compositions comprising a therapeutically effective amount of a compound of the present invention and one or more pharmaceutically acceptable excipients. The present invention is further directed to a methods of treating presbyopia or glaucoma or reducing hyperemia comprising administering to a patient in need thereof a therapeutically effective amount of a compound of the present invention.

  本发明涉及式如下的化合物 及其盐或酯。本发明进一步涉及眼科组合物，其包含治疗有效量的本发明化合物和一种或多种药学上可接受的赋形剂。本发明进一步涉及一种治疗老花眼或青光眼或减少高眼压症的方法，包括向有需要的患者施用治疗有效量的本发明化合物。
• Prodrugs of Quinuclidine Ring-containing Muscarinic Agonists and Compositions and Methods Thereof
  申请人：Presbyopia Therapies LLC

  公开号：US20200181136A1

  公开（公告）日：2020-06-11

  The present invention is directed to derivatives and prodrugs of quinuclidine-ring containing compounds. The present invention is further directed to ophthalmological compositions comprising a therapeutically effective amount of a compound of the present invention and one or more pharmaceutically acceptable excipients. The present invention is further directed to a methods of treating presbyopia or glaucoma or reducing hyperemia comprising administering to a patient in need thereof a therapeutically effective amount of a compound of the present invention.