N-(4-chloro-phenylcarbamimidoyl)-N'-isopropyl-urea | 56858-82-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-chloro-phenylcarbamimidoyl)-N'-isopropyl-urea
• 英文别名: N-(4-Chlor-phenylcarbamimidoyl)-N'-isopropyl-harnstoff；N'-(4-Chlor-phenyl)-N-isopropylcarbamoyl-guanidin；1-[N'-(4-chlorophenyl)carbamimidoyl]-3-propan-2-ylurea
• CAS: 56858-82-3
• 化学式: C₁₁H₁₅ClN₄O
• 分子量: 254.719
• InChiKey: RDHWTOYYXYRPIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  79.5
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(4-氯苯基)胍 、 异氰酸异丙酯 在 苯 作用下， 生成 N-(4-chloro-phenylcarbamimidoyl)-N'-isopropyl-urea
  参考文献：
  名称：

  Curd et al., Journal of the Chemical Society, 1949, p. 1739,1742

  摘要：

  DOI：

文献信息

• PROGUANIL TO TREAT SKIN/MUCOSAL DISEASES
  申请人：Godowski Kenneth C.

  公开号：US20090280069A1

  公开（公告）日：2009-11-12

  Proguanil has been found to have rapid and effective killing activity against a variety of disease-causing micro-organisms. For example, when applied topically, proguanil is particularly effective against Propionibacterium acnes , a bacteria that causes acne; Corynebacterium minutissimum , a bacteria that causes erythrasma, Gardnerella vaginalis , a bacteria that causes vaginosis; Trichomonas vaginalis , a protozoan that causes trichomoniasis and C. albicans , a fungus (a form of yeast).

  Proguanil已被发现对多种病原微生物具有快速有效的杀灭活性。例如，当局部应用时，Proguanil对引起痤疮的丙酸杆菌、引起红斑病的微小棒状杆菌、引起阴道病的阴道芽胞杆菌、引起滴虫病的滴虫原虫和真菌（一种酵母菌）的白色念珠菌等特别有效。
• SYNERGISTIC COMBINATION OF BIOCIDES
  申请人：Lonza Inc.

  公开号：EP3457850A1

  公开（公告）日：2019-03-27
• ATOVAQUONE WITH A PARTICLE SIZE DIAMETER RANGE (D90) OF GREATER THAN 3 MICRONS TO ABOUT 10 MICRONS
  申请人：Mooney Brett Antony

  公开号：US20110206770A1

  公开（公告）日：2011-08-25

  Atovaquone or a pharmaceutically acceptable salt thereof having a particle size diameter range with a D 90 of between greater than 3 to about 10 μm.
• SYNERGISTIC COMBINATION OF BIOCIDES
  申请人：LONZA LLC

  公开号：US20200305435A1

  公开（公告）日：2020-10-01

  A composition having biocidal properties is disclosed. The composition includes a first biocide that synergistically operates with a second biocide to destroy or inhibit the growth of at least one microorganism. The first biocide comprises a quaternary ammonium salt. The second biocide, on the other hand, may comprise a biguanide. The composition is particularly well suited for use in disinfectant products and for use as a preservative.
• [EN] SYNERGISTIC COMBINATION OF BIOCIDES<br/>[FR] COMBINAISON SYNERGIQUE DE BIOCIDES
  申请人：LONZA AG

  公开号：WO2017222965A1

  公开（公告）日：2017-12-28

  A composition having biocidal properties is disclosed. The composition includes a first biocide that synergistically operates with a second biocide to destroy or inhibit the growth of at least one microorganism. The first biocide comprises a quaternary ammonium salt. The second biocide, on the other hand, may comprise a biguanide. The composition is particularly well suited for use in disinfectant products and for use as a preservative.