2-amino-4-hydroxy-6-methylpyridine | 79175-91-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-amino-4-hydroxy-6-methylpyridine
• 英文别名: 2-amino-6-methyl-pyridin-4-ol；2-Amino-6-methylpyridin-4-ol；2-amino-6-methyl-1H-pyridin-4-one
• CAS: 79175-91-0
• 化学式: C₆H₈N₂O
• mdl: MFCD12828168
• 分子量: 124.142
• InChiKey: CGQOFJKJTMICBC-UHFFFAOYSA-N

物化性质

• 沸点：
  441.1±40.0 °C(Predicted)
• 密度：
  1.245±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-amino-4-hydroxy-6-methylpyridine 、 1,6-己二异氰酸酯 反应 16.0h， 生成 2-(6-isocyanatohexylaminocarbonylamino)-6-methyl-4-pyrimidinone
  参考文献：
  名称：

  Micellization of ω-Functionalized Diblock Copolymers in Selective Solvent. Study on the Effect of Hydrogen Bonds

  摘要：

  Two series of omega-functionalized diblock copolymers polystyrene-b-polyisoprene, PS-PI, having hydroxyl end groups either at the PS (PI-PS-OH) or at the PI (PS-PI-OH) block were synthesized by living anionic polymerization. The samples had similar molecular weights but different compositions. Employing suitable post-polymerization reactions the hydroxyl groups were transformed to the corresponding 2-ureido-4-pyrimidinone (UPy) functions. The UPy group is known to dimerize strongly in a self-complementary array of four cooperative hydrogen bonds. The micellization properties of the unfunctionalized and the omega-functionalized polymers having either hydroxyl or UPy end groups were studied in n-decane, which is a selective solvent for the PI block, by static and dynamic light scattering and dilute solution viscometry. A distinct micellar behavior was obtained depending on the nature of the end group and their location either at the core-forming or the corona-forming block. To confirm the results regarding the effect of the hydrogen bonds the solid-state properties of the copolymers were studied by differential scanning calorimetry and thermogravimetric analysis. Furthermore, the dilute solution properties were investigated in chloroform, which is a common good solvent for both the PS and PI blocks but nonpolar, thus allowing the formation of hydrogen bonds.

  DOI：

  10.1021/ma061396n
• 作为产物：
  描述：

  4-羟基-2-甲基吡啶 在 sodium amide 、 paraffin oil 作用下， 生成 2-amino-4-hydroxy-6-methylpyridine
  参考文献：
  名称：

  Bojarska-Dahlig; Gruda, Roczniki Chemii, 1959, vol. 33, p. 505

  摘要：

  DOI：

文献信息

• [EN] 2-PYRIDYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS<br/>[FR] INHIBITEURS DE TYROSINE KINASE DE LA RATE (SYK) CONTENANT UN 2-PYRIDYL CARBOXAMIDE
  申请人：MERCK SHARP & DOHME

  公开号：WO2013052394A1

  公开（公告）日：2013-04-11

  The invention provides certain 2-pyridyl carboxamide-containing compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein A and B are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.

  本发明提供了一些含有2-吡啶甲酰胺的化合物，其化学式为(I)或药用可接受的盐，其中A和B按本发明定义。本发明还提供了包含这些化合物的药物组合物，以及使用这些化合物来治疗由脾酪氨酸激酶（Syk）介导的疾病或状况的方法。
• Synthesis of Polysubstituted Pyridopyrimidines, Pyrimidines, and Pyrazoles Based on 1,1-Bis(1H-benzotriazol-1-yl)-and 1,1-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-3,4,4-trichloro-2-nitrobuta-1,3-dienes
  作者：I. A. Kolesnyk、S. K. Petkevich、A. D. Tsaryk、P. V. Kurman、V. I. Potkin

  DOI：10.1134/s1070428020010042

  日期：2020.1

  polysubstituted pyrido[1,2-a]pyrimidine derivative with an aminopyridine residue in the 2-position, whereas heterocyclization of 3,4,4-trichloro-1,1-bis(1H-benzotriazol-1-yl)-2-nitrobuta-1,3-diene with substituted 2-aminopyridines afforded 2-(1H-berrzotriazol-1-yl)pyrido[1,2-a]pyrimidines. 2-(Morpholin-4-yl), 2-amino, and 2-(2-hydroxyethylamino) derivatives of polysubstituted pyrido[1,2-a]pyrimidines were

  3,4,4-三氯-1,1-双（3,5-二甲基-1 H-吡唑-1-基）-2-硝基丁-1,3-二烯与2-氨基吡啶的反应得到多取代的吡啶基[1,2- a ]嘧啶衍生物的2-位带有氨基吡啶残基，而3,4,4-三氯-1,1-双（1 H-苯并三唑-1-基）-2-硝基丁-的杂环化作用用取代的2-氨基吡啶的1，3-二烯得到2-（1H -berrzotriazol-1-基）吡啶并[1,2- a ]嘧啶。多取代吡啶并[1,2- a的2-（吗啉-4-基），2-氨基和2-（2-羟乙基氨基）衍生物合成]嘧啶，并将含有2-羟乙基氨基的嘧啶转化为相应的4，5-二氯-1，2-噻唑-1-羧酸酯。揭示了三氯硝基-1,3-丁二烯的苯并三唑基和二甲基吡唑基衍生物杂环化为嘧啶和吡唑体系的具体特征。
• COSMETIC TREATMENT PROCESSES AND KIT
  申请人：Dublanchet Anne-Claude

  公开号：US20140155352A1

  公开（公告）日：2014-06-05

  The present invention relates to a cosmetic process for treating keratin materials, which can give them, especially in a long-lasting and reversible manner, interesting cosmetic properties; this process comprising the application to said materials: in a first stage, of a cosmetic composition comprising at least one graftable species, comprising at least one unit of formula (Ia): and in a second stage, of a cosmetic composition comprising at least one cosmetic active agent bearing at least one unit of formula (Ia): The invention also relates to a kit comprising said compositions.

  本发明涉及一种用于处理角蛋白材料的化妆品工艺，可以在长期和可逆的情况下赋予它们有趣的化妆品特性；该工艺包括向所述材料施加以下组成部分的应用：第一阶段，包括至少一种可接枝的物种的化妆品组合物，其中包括至少一个式(Ia)的单元；第二阶段，包括至少一种具有至少一个式(Ia)的化妆品活性剂的化妆品组合物：本发明还涉及包括所述组合物的套件。
• Tetrazolyl substituted imidazo\x9b1,2-a!pyridinylalkyl compounds for
  申请人：G.D. Searle & Co.

  公开号：US05716964A1

  公开（公告）日：1998-02-10

  A class of imidazo\x9b1,2-a!pyridinylalkyl compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a compound of this class alone or in a composition in an amount effective as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula: ##STR1## wherein each of R.sup.22, R.sup.23 and R.sup.24 is independently selected from hydrido, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl; wherein each of Y.sub.m and Y.sub.n is a spacer group independently selected methylene and ethylene radicals which may be unsubstituted and from methylene radicals which may be substituted with a group selected from halo, hydroxy and oxo; wherein each of m and n is a number independently selected from zero to two, inclusive; wherein each X and T is one or more groups independently selected from hydrido, alkyl, cycloalkyl, halo, haloalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl and alkanoyl; or a pharmaceutically-acceptable salt thereof.

  本文描述了一类咪唑并[1,2-a]吡啶基烷基化合物，用于治疗与缺氧或缺血有关的神经毒性损伤，通常是中风、心脏骤停或围产窒息后的典型症状。该治疗方法包括单独或在组合物中给予该类化合物，其剂量足以作为拮抗剂抑制主要神经元兴奋性氨基酸受体位点的兴奋毒性作用。最有兴趣的化合物是公式为：##STR1## 其中R.sup.22、R.sup.23和R.sup.24各自独立选择自氢、甲基、乙基、正丙基、异丙基、正丁基、异丁基、叔丁基、环丙基、环丁基、环戊基、环己基和环庚基；其中Y.sub.m和Y.sub.n各自是独立选择的亚氨基和乙亚氨基基团，它们可以是未取代的亚甲基和乙烯基基团，也可以是取代了卤素、羟基和氧代基的亚甲基基团；其中m和n各自是从零到二的数字，包括零和二；其中每个X和T是一个或多个基团，独立地选择自氢、烷基、环烷基、卤素、卤代烷基、羟基、羟基烷基、烷氧基、烷氧基烷基和烷酰基；或其药学上可接受的盐。
• Imidazo[1,2-a]pyridinylalkyl compounds for treatment of neurotoxic injury
  申请人：G.D. Searle & Co.

  公开号：EP0436831A2

  公开（公告）日：1991-07-17

  A class of imidazo[1,2-a]pyridinylalkyl compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a compound of this class alone or in a composition in an amount effective as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula: wherein each of R22, R23 and R24 is independently selected from hydrido, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl; wherein each of Ym and Yn is a spacer group independently selected methylene and ethylene radicals which may be unsubstituted and from methylene radicals which may be substituted with a group selected from halo, hydroxy and oxo; wherein each of m and n is a number independently selected from zero to two, inclusive; wherein each X and T is one or more groups independently selected from hydrido, alkyl, cycloalkyl, halo, haloalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl and alkanoyl; or a pharmaceutically-acceptable salt thereof.

  描述了一类咪唑并[1,2-a]吡啶烷基化合物，用于治疗减少与缺氧或缺血相关的神经毒性损伤，这种损伤通常发生在中风、心脏骤停或围产期窒息之后。治疗方法包括单独施用或在组合物中施用该类化合物，施用量为有效的拮抗剂，以抑制主要神经元兴奋性氨基酸受体部位的兴奋毒性作用。最令人感兴趣的化合物是式中的化合物： 其中 R22、R23 和 R24 各自独立地选自肼、甲基、乙基、正丙基、异丙基、正丁基、异丁基、仲丁基、叔丁基、环丙基、环丁基、环戊基、环己基和环庚基；其中 Ym 和 Yn 各自是一个间隔基团，该间隔基团独立地选自可能未被取代的亚甲基和亚乙基，以及可能被选自卤代、羟基和氧代的基团取代的亚甲基；其中每个 m 和 n 是独立选自 0 至 2（包括 2）的数字；其中每个 X 和 T 是一个或多个独立选自氢基、烷基、环烷基、卤基、卤代烷基、羟基、羟基烷基、烷氧基、烷氧基烷基和烷酰基的基团；或其药学上可接受的盐。