2-Diazo-1-(3,5-dimethylphenyl)ethanone | 165810-46-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Diazo-1-(3,5-dimethylphenyl)ethanone
• CAS: 165810-46-8
• 化学式: C₁₀H₁₀N₂O
• 分子量: 174.202
• InChiKey: DWYOKLCRSCYPSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  19.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Diazo-1-(3,5-dimethylphenyl)ethanone 在 silver(l) oxide 作用下， 以 1,4-二氧六环 为溶剂， 生成 3,5-二甲基苯乙酸
  参考文献：
  名称：

  Quinolones as gonadotropin releasing hormone (GnRH) antagonists: simultaneous optimization of the C(3)-aryl and C(6)-substituents

  摘要：

  A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to he optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00318-8
• 作为产物：
  描述：

  3,5-二甲基苯甲酸 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 生成 2-Diazo-1-(3,5-dimethylphenyl)ethanone
  参考文献：
  名称：

  Quinolones as gonadotropin releasing hormone (GnRH) antagonists: simultaneous optimization of the C(3)-aryl and C(6)-substituents

  摘要：

  A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to he optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00318-8

文献信息

• Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity
  作者：Helen M. Armstrong、Frederick Wong、Mark A. Holmes、Peter J. Sinclair、Mark T. Goulet、Francis J. Dumont、MaryJo Staruch、Samuel Koprak、Laurence B. Peterson、Raymond Rosa、Mary Beth Wilusz、Gregory J. Wiederrecht、John G. Cryan、Matthew J. Wyvratt、William H. Parsons

  DOI：10.1016/s0960-894x(99)00336-4

  日期：1999.7

  The synthesis of C32-O-arylethyl ether derivatives of ascomycin that possess equivalent immunosuppressant activity but reduced toxicity, compared to FK-506, is described. (C) 1999 Elsevier Science Ltd. All rights reserved.
• GEMINAL BISPHOSPHONIC ACIDS AND DERIVATIVES AS ANTI-ARTHRITIC AGENTS
  申请人：THE UPJOHN COMPANY

  公开号：EP0466730B1

  公开（公告）日：1993-07-21
• US5220021A
  申请人：——

  公开号：US5220021A

  公开（公告）日：1993-06-15
• [EN] GEMINAL BISPHOSPHONIC ACIDS AND DERIVATIVES AS ANTI-ARTHRITIC AGENTS
  申请人：THE UPJOHN COMPANY

  公开号：WO1990012017A1

  公开（公告）日：1990-10-18

  (EN) Unsaturated geminal phosphonates (III), either as the esters, free acids or salts are useful in the treatment of arthritis.(FR) L'invention concerne des phosponates germinaux insaturés (III) à titre soit d'esters, d'acides ou de sels libres utiles dans le traitement de l'arthrite.