5-chloro-2-(4-methoxyphenylamino)benzoic acid | 76206-20-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-chloro-2-(4-methoxyphenylamino)benzoic acid
• 英文别名: 2-p-anisidino-5-chloro-benzoic acid；2-p-Anisidino-5-chlor-benzoesaeure；5-Chlor-N-(4-methoxy-phenyl)-anthranilsaeure；5-chloro-2-(4-methoxyanilino)benzoic acid
• CAS: 76206-20-7
• 化学式: C₁₄H₁₂ClNO₃
• 分子量: 277.707
• InChiKey: ISXKTCMFCWGVAH-UHFFFAOYSA-N

物化性质

• 熔点：
  189 °C
• 沸点：
  433.0±45.0 °C(Predicted)
• 密度：
  1.361±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-chloro-2-(4-methoxyphenylamino)benzoic acid 在 三氯氧磷 、 苯酚 作用下， 生成 N-(2-chloro-7-methoxy-acridin-9-yl)-glycine
  参考文献：
  名称：

  Singh; Singh; Singh, Journal of the Indian Chemical Society, 1947, vol. 24, p. 79,81

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(4-methoxyphenyl)benzimidoyl chloride 在 sodium hydroxide 、 乙醚 、 sodium ethanolate 作用下， 生成 5-chloro-2-(4-methoxyphenylamino)benzoic acid
  参考文献：
  名称：

  411.二苯胺的某些衍生物以及N-芳基邻氨基苯甲酸和cri烯的新合成

  摘要：

  DOI：

  10.1039/jr9370001954

文献信息

• Substituted aminobenzamides and their use as agents which inhibit
  申请人：Sterling Drug Inc.

  公开号：US04510139A1

  公开（公告）日：1985-04-09

  Novel 2-(hydroxyphenylamino)benzamides and oxidation products thereof, useful as inhibitors of lipoxygenase, are of the formulas ##STR1## wherein R is hydrogen, lower-alkyl, halo or lower-alkoxy; R' is hydrogen or lower-alkyl; R" is hydrogen, lower-alkyl or halo; and N.dbd.Z is amino or substituted amino. The compounds of Formula I are prepared by de-etherification of the corresponding alkyl or benzyl ethers; and the compounds of Formula II are prepared by oxidation of the compounds of Formula I where R' is hydrogen and OH is in the 4-position.

  Novel 2-(羟基苯胺基)苯甲酰胺及其氧化产物，可用作芦丁氧化酶抑制剂，其化学式如下：##STR1## 其中R为氢、较低烷基、卤素或较低烷氧基；R'为氢或较低烷基；R"为氢、较低烷基或卤素；N.dbd.Z为氨基或取代氨基。式I的化合物通过相应的烷基或苄基醚的脱醚制备；式II的化合物通过氧化式I的化合物制备，其中R'为氢且OH位于4位。
• Benzyl alcohol derivatives, their preparation and use
  申请人：Sterling Drug Inc.

  公开号：US04496590A1

  公开（公告）日：1985-01-29

  Novel hydroxyphenylaminobenzenealkanols, useful as antiasthmatic agents, are of the formula ##STR1## wherein R is hydrogen, lower-alkyl, lower-alkoxy or halo; R' is hydrogen or lower-alkyl; R" is hydrogen, lower-alkyl or halo; and Y is C.sub.n H.sub.2n wherein n is 1-2. The compounds are prepared by de-etherification of the corresponding phenol alkyl or benzyl ethers; by reduction of the corresponding benzoic acids or esters thereof; or by reduction of ketones wherein --Y--OH is replaced by --COCH.sub.3.

  新型羟基苯胺基苯丙醇，作为抗哮喘剂有用，其化学式为##STR1##其中R为氢、较低烷基、较低烷氧基或卤素；R'为氢或较低烷基；R"为氢、较低烷基或卤素；Y为C.sub.n H.sub.2n，其中n为1-2。这些化合物通过对应苯酚烷基或苄醚的脱醚化制备；通过对应苯甲酸或其酯的还原制备；或通过酮的还原，其中--Y--OH被--COCH.sub.3取代。
• Substituted diphenylamine derivatives, compositions and herbicidal uses thereof, and processes for their preparation
  申请人：ICI AUSTRALIA LIMITED

  公开号：EP0013144A1

  公开（公告）日：1980-07-09

  The compounds are herbicides. Herbicidal compositions containing as active ingredient a compound of formula I, a process for severely damaging or killing unwanted plants by applying to the plants or to the growth medium of the plants an effective amount of a compound of formula I, processes for the preparation of compounds of formula I and intermediates useful in the preparation of compounds of formula I are described. Prepared are compounds of formula I or a salt thereof wherein: A, B, D, E, T, U and V are independently chosen from the group consisting of hydrogen, halogen, nitro, cyano, thiocyano, possibly halogenated alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, possibly alkylated amino, sulfo, sulfamoyl, carboxy, carbamoyl, C2 to C6 alkenyl, C3 to C7 cyclo-alkyl, possibly substituted phenyl, phenoxy, phenylthio groups, and wherein at least one of A, B, D, E and T is not hydrogen, the alkyl groups containing 1 to 6 carbon atoms, R' is chosen from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, haloalkyl, alkanoyl, all containing at most 10 carbon atoms, or possibly substituted phenyl, benzyl, benzoyl, R2 is chosen from the group consisting of hydrogen, alkyl, alkenyl, alkoxyalkyl, haloalkyl, all containing at most 6 carbon atoms, and acetyl, propionyl, and C2 to C6 alkoxy-carbonyl, R3 is chosen from the group consisting of hydrogen, alkyl, alkenyl, alkoxyalkyl, all containing at most 6 carbon atoms, and C1 to C4 haloalkyl, or R2 and R3 together may form a C1 to C3 alkylidene group, W is chosen from the group consisting of cyano, thiocar- bamoyl, -C-G and CH2Z wherein: G is chosen from the group consisting of hydroxy, mercapto, possibly substituted C1 to C10 alkoxy, and C2 to C10 alkenyloxy, C2 to C10 alkynyloxy, C1 to C10alkylthio, C2 to C10 alkenylthio, C2 to C10 alkynylthio, possibly substituted C3 to C7 cycloalkoxy, possibly substituted phenoxy, phenylthio, benzyloxy, benzylthio, the group OM wherein M is the cation of an inorganic or organic base, the group-NNSO2R4 wherein R4 is chosen from C4 to C10, alkyl and C, to C10 haloalkyl, and the group -NR5R6 wherein R5 and R6 are independently chosen from the group consisting of hydrogen, C1 to C6 alkyl, phenyl and benzyl or R5 and R6 together form a heterocyclic ring and Z is chosen from the group consisting of halogen, hydroxy, mercapto, possibly substituted C1 to C10 alkoxy, possibly substituted C1 to C10 alkylthio, formyl, and the group NR5R6 wherein R5 and R6 are as hereinbefore defined: X is chosen from oxygen and sulfur and n is 0, 1 or 2.

  这些化合物是除草剂。本文描述了含有作为活性成分的式 I 化合物的除草组合物、通过向植物或植物生长介质施用有效量的式 I 化合物来严重损害或杀死不需要的植物的工艺、制备式 I 化合物的工艺以及用于制备式 I 化合物的中间体。 制备的式 I 化合物 或其盐，其中 磺酰胺基、羧基、氨基甲酰基、C2 至 C6 烯基、C3 至 C7 环烷基、可能取代的苯基、苯氧基、苯硫基，其中 A、B、D、E 和 T 中至少有一个不是氢，烷基含有 1 至 6 个碳原子、 R'选自由氢、烷基、烯基、炔基、烷氧基烷基、卤代烷基、烷酰基组成的组，所有烷基均含有至多 10 个碳原子，或可能是取代的苯基、苄基、苯甲酰基、 R2 选自氢、烷基、烯基、烷氧基烷基、卤代烷基（均最多含有 6 个碳原子）、乙酰基、丙酰基和 C2 至 C6 烷氧基羰基组成的组，R3 选自氢、烷基、烯基、烷氧基烷基（均最多含有 6 个碳原子）和 C1 至 C4 卤代烷基组成的组，或 R2 和 R3 可共同形成 C1 至 C3 亚烷基、 W 选自氰基、硫代氨基甲酰基、-C-G 和 CH2Z 所组成的组，其中： G 选自由羟基、巯基、可能取代的 C1 至 C10 烷氧基、C2 至 C10 烯氧基、C2 至 C10 烷炔氧基、C1 至 C10 烷硫基、C2 至 C10 烯硫基、C2 至 C10 烷炔硫基、可能取代的 C3 至 C7 环烷氧基、可能取代的苯氧基、苯硫基、苄氧基、苄硫基组成的组、基团 OM（其中 M 是无机碱或有机碱的阳离子）、基团-NNSO2R4（其中 R4 选自 C4 至 C10 烷基和 C, 至 C10 卤代烷基）和基团-NR5R6（其中 R5 和 R6 独立地选自氢、C1 至 C6 烷基、苯基和苄基组成的组，或 R5 和 R6 共同形成杂环，以及 Z 选自由卤素、羟基、巯基、可能取代的 C1 至 C10 烷氧基、可能取代的 C1 至 C10 硫代烷基、甲酰基和基团 NR5R6（其中 R5 和 R6 如前定义）组成的组： X 选自氧和硫，以及 n 为 0、1 或 2。
• Phenylaminobenzenealkanols and preparation
  申请人：STERLING DRUG INC.

  公开号：EP0122518A1

  公开（公告）日：1984-10-24

  Novel hydroxyphenylaminobenzenealkanols, useful as antiasthmatic agents, are of the formula wherein R is hydrogen, lower-alkyl, lower-alkoxy or halo; R'is hydrogen or lower-alkyl; R"is hydrogen, lower-alkyl or halo; and Y is CnH2n wherein n is 1-2. The compounds are prepared by de-etherification of the corresponding phenol alkyl or benzyl ethers; by reduction of the corresponding benzoic acids or esters thereof; or by reduction of ketones wherein -Y-OH is replaced by -COCH3. The invention also relates to the novel benzyl ether intermediates.

  可用作抗哮喘药的新型羟苯胺苯烷醇的结构式为 其中 R 是氢、低级烷基、低级烷氧基或卤素；R'是氢或低级烷基；R "是氢、低级烷基或卤素；Y 是 CnH2n，其中 n 是 1-2。这些化合物的制备方法有：相应的苯酚烷基醚或苄基醚的脱醚；相应的苯甲酸或其酯的还原；或酮的还原，其中 -Y-OH 被 -COCH3 取代。本发明还涉及新型苄基醚中间体。
• Drosdow; Lesnowa, Zhurnal Obshchei Khimii, 1935, vol. 5, p. 690,695
  作者：Drosdow、Lesnowa

  DOI：——

  日期：——