6-Methyl-4,6-dihydro-1H-pyrimido[4,5-c][1,2]oxazin-7(3H)-one | 124928-61-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-Methyl-4,6-dihydro-1H-pyrimido[4,5-c][1,2]oxazin-7(3H)-one
• 英文别名: 6-methyl-3,4-dihydro-1H-pyrimido[4,5-c]oxazin-7-one
• CAS: 124928-61-6
• 化学式: C₇H₉N₃O₂
• 分子量: 167.17
• InChiKey: HHQSKAUVGFQTCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  53.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-[2-[1-methyl-2-oxo-4-(1,2,4-triazol-1-yl)pyrimidin-5-yl]ethoxy]isoindole-1,3-dione 以100%的产率得到
  参考文献：
  名称：

  KONG, THOO LIN PAUL V. S.;BROWN, D. M., NUCLEOSIDES AND NUCLEOTIDES, 8,(1989) N-6, C. 871-874

  摘要：

  DOI：

文献信息

• [EN] OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF<br/>[FR] COMPOSITIONS D'OLIGONUCLÉOTIDES ET PROCÉDÉS ASSOCIÉS
  申请人：WAVE LIFE SCIENCES LTD

  公开号：WO2022099159A1

  公开（公告）日：2022-05-12

  Among other things, the present disclosure provides oligonucleotides and compositions thereof. In some embodiments, provided oligonucleotides and compositions are useful for adenosine modification. In some embodiments, the present disclosure provides methods for treating various conditions, disorders or diseases that can benefit from adenosine modification.

  除其他事项外，本公开提供寡核苷酸及其组合物。在某些实施例中，提供的寡核苷酸及其组合物对腺苷修饰有用。在某些实施例中，本公开提供了治疗各种需要腺苷修饰的疾病、疾病或病症的方法。
• PNA monomer and precursor
  申请人：Panagene, Inc.

  公开号：EP2174936A1

  公开（公告）日：2010-04-14

  This application relates to monomers of the general formula (I) for the preparation PNA (peptide nucleic acid) oligomers and provides method for the synthesis of both predefined sequence PNA oligomers and random sequence PNA oligomers: (I) wherein E is nitrogen or C-R'; J is sulfur or oxygen; R', R1, R2, R3, R4 is independently H, halogen, alkyl, nitro, nitrile, alkoxy, halogenated alkyl, halogenated alkoxy, phenyl or halogenated phenyl, R5 is H or protected or unprotected side chain of natural or unnatural a-amino acid; and B is a natural or unnatural nucleobase, wherein when said nucleobase has an exocyclic amino function, said function is protected by protecting group which is labile to acids but stable to weak to medium bases in the presence of thiol.

  本申请涉及用于制备 PNA（肽核酸）寡聚体的通式（I）单体，并提供了预定序列 PNA 寡聚体和随机序列 PNA 寡聚体的合成方法：(I) 其中 E 是氮或 C-R'；J 是硫或氧；R'、R1、R2、R3、R4 独立地是 H、卤素、烷基、硝基、腈基、烷氧基、卤代烷基、卤代烷氧基、苯基或卤代苯基；R5 是 H 或天然或非天然 a-氨基酸的受保护或未受保护侧链；B 是天然或非天然核碱基，其中当所述核碱基具有外环氨基功能时，所述功能受保护基团保护，该保护基团对酸不稳定，但在硫醇存在下对弱碱至中碱稳定。
• An improved method for synthesising templated molecules
  申请人：Nuevolution A/S

  公开号：EP2186897A1

  公开（公告）日：2010-05-19

  The invention relates to a method for synthesising templated molecules which are covalently attached to the templated, which directed the synthesis of the templated molecule, and/or covalently attached to the complementary templated. The methods of the invention can be used for generating libraries of bifunctional complexes comprising templated molecules which may be selected for biological activity.

  本发明涉及一种合成模板分子的方法，模板分子与模板共价连接，引导模板分子的合成，和/或与互补模板共价连接。本发明的方法可用于生成包含模板分子的双功能复合物库，这些复合物可根据生物活性进行选择。
• Synthesis of a bifunctional complex
  申请人：Nuevolution A/S

  公开号：EP2348124A2

  公开（公告）日：2011-07-27

  Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part wherein a nascent bifunctional complex comprising a chemical reaction site and priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site using one or more enzymes.

  本发明公开了一种获得包含显示分子部分和编码部分的双功能复合物的方法，其中包含化学反应位点和用于酶加标记的引物位点的新生双功能复合物在化学反应位点与一种或多种反应物反应，并在引物位点使用一种或多种酶提供识别反应物的相应标记。
• Method for the synthesis of a bifunctional complex
  申请人：Nuevolution A/S

  公开号：EP2348125A2

  公开（公告）日：2011-07-27

  Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part wherein a nascent bifunctional complex comprising a chemical reaction site and priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site using one or more enzymes.

  本发明公开了一种获得包含显示分子部分和编码部分的双功能复合物的方法，其中包含化学反应位点和用于酶加标记的引物位点的新生双功能复合物在化学反应位点与一种或多种反应物反应，并在引物位点使用一种或多种酶提供识别反应物的相应标记。