2-异丙基-N,N,6-三甲基苯胺 | 227199-09-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-异丙基-N,N,6-三甲基苯胺
• 英文名称: 2-Isopropyl-N,N,6-trimethylaniline
• 英文别名: N,N,2-trimethyl-6-propan-2-ylaniline
• CAS: 227199-09-9
• 化学式: C₁₂H₁₉N
• mdl: MFCD01313354
• 分子量: 177.29
• InChiKey: XTYKPEMLMDLYKC-UHFFFAOYSA-N

物化性质

• 沸点：
  102/12mm
• 密度：
  0.914±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 危险品标志：
  Xi
• 海关编码：
  2921430090

文献信息

• COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF
  申请人：BioTheryX, Inc.

  公开号：US20180170948A1

  公开（公告）日：2018-06-21

  The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CK1α, GSPT1, aiolos, and/or ikaros activity, and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of diseases, disorders, or conditions associated with a protein, such as diseases, disorders, and conditions associated with cytokines, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel diseases, Crohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, Alzheimer's disease, and cancer, are provided.

  本发明提供了调节蛋白功能的化合物，以恢复蛋白稳态，包括细胞因子、CK1α、GSPT1、艾奥洛斯和/或伊卡洛斯活性和细胞间粘附。该发明提供了一种调节蛋白介导的疾病的方法，如细胞因子介导的疾病、障碍、状况或反应。提供了包括与其他细胞因子和炎症介质结合的组合物。提供了治疗、改善或预防与蛋白相关的疾病、障碍或状况的方法，包括与细胞因子相关的疾病、障碍和状况，包括炎症、纤维肌痛、类风湿性关节炎、骨关节炎、强直性脊柱炎、银屑病、银屑病关节炎、炎症性肠病、克罗恩病、溃疡性结肠炎、葡萄膜炎、炎症性肺病、慢性阻塞性肺病、阿尔茨海默病和癌症。
• Olefin polymerisation catalysts and processes for producing olefin polymers
  申请人：TOSOH CORPORATION

  公开号：EP0849292A1

  公开（公告）日：1998-06-24

  Catalysts for olefin polymerization which consist essentially of a transition metal compound, a modified clay compound and an organic aluminum compound, wherein the modified clay compound comprises a reaction product of a clay mineral and a proton acid salt of a specific amine compound, as well as a method of polymerizing olefins using such catalysts. It is possible thereby to obtain olefin polymers with high productivity and low ash content.

  烯烃聚合催化剂，主要由过渡金属化合物、改性粘土化合物和有机铝化合物组成，其中改性粘土化合物包括粘土矿物和特定胺化合物的质子酸盐的反应产物，以及使用这种催化剂聚合烯烃的方法。由此可以获得生产率高、灰分含量低的烯烃聚合物。
• Catalyst for olefin polymer production and process for olefin polymer production employing the catalyst
  申请人：TOSOH CORPORATION

  公开号：EP0942006A2

  公开（公告）日：1999-09-15

  A novel catalyst for olefin polymerization is provided which comprises [A] a metallocene compound containing a transition metal selected from Groups 3, 4, 5, and 6 of Periodic Table, [B] a reaction product of topotactic reduction by electron transfer, and [C] an organoaluminum compound. The catalyst may contain additionally [D] an organoalkaline earth metal compound or an organozinc compound. This catalyst has high catalytic activity for olefin polymerization without employing an expensive catalyst component.

  提供了一种用于烯烃聚合的新型催化剂，它包括[A]一种含有选自元素周期表第 3、4、5 和 6 族的过渡金属的茂金属化合物，[B]一种通过电子转移进行拓扑还原的反应产物，以及[C]一种有机铝化合物。催化剂中还可添加 [D] 有机碱土金属化合物或有机锌化合物。这种催化剂对烯烃聚合具有很高的催化活性，而无需使用昂贵的催化剂组分。
• Compounds targeting proteins, compositions, methods, and uses thereof
  申请人：BioTheryX, Inc.

  公开号：US10040804B2

  公开（公告）日：2018-08-07

  The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CK1α, GSPT1, aiolos, and/or ikaros activity, and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of diseases, disorders, or conditions associated with a protein, such as diseases, disorders, and conditions associated with cytokines, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel diseases, Crohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, Alzheimer's disease, and cancer, are provided.

  本发明提供了调节蛋白质功能的化合物，以恢复蛋白质的平衡，包括细胞因子、CK1α、GSPT1、aiolos 和/或 ikaros 活性以及细胞-细胞粘附性。本发明提供了调节蛋白质介导的疾病，如细胞因子介导的疾病、失调、病症或反应的方法。本发明提供了组合物，包括与其他细胞因子和炎症介质的组合物。提供了治疗、改善或预防与蛋白质相关的疾病、失调或病症的方法，例如与细胞因子相关的疾病、失调和病症，包括炎症、纤维肌痛、类风湿性关节炎、骨关节炎、强直性脊柱炎、银屑病、银屑病关节炎、炎症性肠病、克罗恩病、溃疡性结肠炎、葡萄膜炎、炎症性肺病、慢性阻塞性肺病、阿尔茨海默病和癌症。
• Ethylene Oligomerization Catalyst Systems Using Chemically-Treated Solid Oxides
  申请人：Chevron Phillips Chemical Company LP

  公开号：US20170341068A1

  公开（公告）日：2017-11-30

  Disclosed herein are catalyst compositions containing a heteroatomic ligand transition metal compound complex, a chemically-treated solid oxide, and an organoaluminum compound. These catalyst compositions can be used in an ethylene oligomerization process to produce a liquid oligomer product containing hexene and octene, as well as a solid polymer product with a molecular weight sufficiently high to permit easy separation of the liquid oligomer product from the solid polymer product.