N-hydroxy-N-methyl-6-(6-methoxy-2-naphthyl)-6-oxohexanamide | 110842-46-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-hydroxy-N-methyl-6-(6-methoxy-2-naphthyl)-6-oxohexanamide
• 英文别名: N-hydroxy-6-(6-methoxynaphthalen-2-yl)-N-methyl-6-oxohexanamide
• CAS: 110842-46-1
• 化学式: C₁₈H₂₁NO₄
• 分子量: 315.369
• InChiKey: UEABSBWOYCMIQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-(6-Methoxy-2-naphthyl)-6-oxohexanoic acid 在 草酰氯 、 三乙胺 作用下， 以 四氢呋喃 、 水 、 苯 为溶剂， 反应 3.0h， 生成 N-hydroxy-N-methyl-6-(6-methoxy-2-naphthyl)-6-oxohexanamide
  参考文献：
  名称：

  Novel 6-oxo-6-naphthylhexanoic acid derivatives with anti-inflammatory and 5-lipoxygenase inhibitory activity

  摘要：

  A series of novel 6-(6-alkoxy-2-naphthyl)oxoalkanoates and alkanamides were synthesized as inhibitors of inflammation and 5-lipoxygenase. They were evaluated in vivo for anti-inflammatory activity in the established adjuvent arthritis assay in rats and in vitro as inhibitors of 5-lipoxygenase in rat basophilic leukemia (RBL) cells. N-Hydroxy-N-methyl-6-(6-methoxy-2-naphthyl)-6-oxohexanamide, compound 28, which is representative of the more potent anti-inflammatory / 5-lipoxygenase inhibitors in the series was approximately twice as potent as the standard, ibuprofen in the adjuvent rat and exhibited an IC50 of 0.25 micromolar in the RBL assay.

  DOI：

  10.1016/0223-5234(91)90025-i

文献信息

• Hydroxamic acids and esters
  申请人：Ortho Pharmaceutical Corporation

  公开号：US04681894A1

  公开（公告）日：1987-07-21

  The synthesis of amido substituted naphthalenes and their intermediates is described. The intermediates and amido substituted naphthalenes are useful as anti-inflammatory agents.

  描述了酰胺取代萘和它们的中间体的合成。这些中间体和酰胺取代的萘可用作抗炎药物。
• Amido substituted naphthalene and intermediates thereof
  申请人：ORTHO PHARMACEUTICAL CORPORATION

  公开号：EP0261759B1

  公开（公告）日：1991-04-17
• MURRAY, WILLIAM V.;WACHTER, MICHAEL P.
  作者：MURRAY, WILLIAM V.、WACHTER, MICHAEL P.

  DOI：——

  日期：——
• US4681894A
  申请人：——

  公开号：US4681894A

  公开（公告）日：1987-07-21
• US4814487A
  申请人：——

  公开号：US4814487A

  公开（公告）日：1989-03-21