2α,5α,6β-Tribromcholestan-3-on | 3903-48-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 2α,5α,6β-Tribromcholestan-3-on
• 英文别名: 2α.5.6β-tribromo-5α-cholestanone-(3)；2α.5.6β-Tribrom-5α-cholestanon-(3)；2α,5α,6β-Tribrom-cholestanon-(3)；(2R,5R,6R,8S,9S,10R,13R,14S,17R)-2,5,6-tribromo-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,4,6,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
• CAS: 3903-48-8
• 化学式: C₂₇H₄₃Br₃O
• 分子量: 623.35
• InChiKey: KLQRFPVQCXQIOJ-CGEQZYHSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.3
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2α,5α,6β-Tribromcholestan-3-on 在 zinc diacetate 、 溶剂黄146 、 sodium iodide 、 苯 作用下， 生成 1H-吡唑-4,5-二胺,1-羟基-N4,N5-二甲基-,2-氧化
  参考文献：
  名称：

  Pathophysiology and diagnosis of third carpal bone disease in horses: A review

  摘要：

  Third carpal bone (C3) disease is a significant cause of lameness in Standardbred and Thoroughbred horses. The bone density of C3 increases as a result of exercise, reducing the compliance of the bone and predisposing it to injury. Currently, the most widely used method of diagnosis is subjective radiography using the tangential view. Radiographically, increases in bone mineral density (BMD) appear as sclerosis but it is not known at what point increases in sclerosis indicate the onset of disease or increased risk of C3 fracture. A quantitative assessment of the BMD of C3 in horses would improve understanding of the changes that occur within this bone and guide athletic management, as it is thought that BMD changes precede articular cartilage damage.Methods of non-invasive bone-mineral analysis used for the detection of osteoporosis in humans include single photon absorptiometry (SPA), dual x-ray absorptiometry (DXA), computed tomography (CT), radioabsorptiometry (RA), quantitative ultrasonography (QU) and magnetic resonance imaging (MRI). To date, DXA and RA are the most commonly used methods of quantitative non-invasive bone-mineral analysis in horses. The cost of equipment and difficulties in performing DXA in live animals preclude the routine use of this technique for diagnostic purposes. RA may become clinically applicable to C3 analysis in horses, but small variations in x-ray beam angle when taking the tangential view significantly affect results, making this technique clinically inapplicable at this time. Currently, methods of quantitative non-invasive bone-mineral analysis of C3 in horses are not suited to clinical application.

  DOI：

  10.1080/00480169.2002.36241
• 作为产物：
  描述：

  5,6β-dibromo-5α-cholestan-3-one 在 乙醚 、 溴 、 溶剂黄146 作用下， 生成 2α,5α,6β-Tribromcholestan-3-on
  参考文献：
  名称：

  Pathophysiology and diagnosis of third carpal bone disease in horses: A review

  摘要：

  Third carpal bone (C3) disease is a significant cause of lameness in Standardbred and Thoroughbred horses. The bone density of C3 increases as a result of exercise, reducing the compliance of the bone and predisposing it to injury. Currently, the most widely used method of diagnosis is subjective radiography using the tangential view. Radiographically, increases in bone mineral density (BMD) appear as sclerosis but it is not known at what point increases in sclerosis indicate the onset of disease or increased risk of C3 fracture. A quantitative assessment of the BMD of C3 in horses would improve understanding of the changes that occur within this bone and guide athletic management, as it is thought that BMD changes precede articular cartilage damage.Methods of non-invasive bone-mineral analysis used for the detection of osteoporosis in humans include single photon absorptiometry (SPA), dual x-ray absorptiometry (DXA), computed tomography (CT), radioabsorptiometry (RA), quantitative ultrasonography (QU) and magnetic resonance imaging (MRI). To date, DXA and RA are the most commonly used methods of quantitative non-invasive bone-mineral analysis in horses. The cost of equipment and difficulties in performing DXA in live animals preclude the routine use of this technique for diagnostic purposes. RA may become clinically applicable to C3 analysis in horses, but small variations in x-ray beam angle when taking the tangential view significantly affect results, making this technique clinically inapplicable at this time. Currently, methods of quantitative non-invasive bone-mineral analysis of C3 in horses are not suited to clinical application.

  DOI：

  10.1080/00480169.2002.36241

文献信息

• Butenandt; Schramm, Chemische Berichte, 1936, vol. 69, p. 2289,2295
  作者：Butenandt、Schramm

  DOI：——

  日期：——
• Inhoffen, Chemische Berichte, 1936, vol. 69, p. 1702,1709
  作者：Inhoffen

  DOI：——

  日期：——
• Bromination of 5α,6β-Dibromocholestane-3-one
  作者：Mary Fieser、Miguel A. Romero、Louis F. Fieser

  DOI：10.1021/ja01617a045

  日期：1955.6