2-(2,4-dichlorophenyl)-1,3-dithiolane | 83521-72-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,4-dichlorophenyl)-1,3-dithiolane
• 英文别名: 2-(2,4-Dichlor-phenyl)-[1,3]dithiolan
• CAS: 83521-72-6
• 化学式: C₉H₈Cl₂S₂
• 分子量: 251.201
• InChiKey: UCYKMVSEQPLQBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,2-乙二硫醇 、 1,1-diacetoxy-1-(2,4-dichlorophenyl)methane 在 POCl₃ on montmorillonite 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 以90%的产率得到2-(2,4-dichlorophenyl)-1,3-dithiolane
  参考文献：
  名称：

  A Facile and Efficient Procedure for the Transdithioacetalization of 1,1‐Diacetates Using POCl₃‐Montmorillonite as Catalyst

  摘要：

  A rapid and efficient method for the transdithioacetalization of 1,1-diacetates with 1,2-dithioglycol was described in good to excellent yield catalyzed by POCl3-montmorillonite.

  DOI：

  10.1081/scc-200036588

文献信息

• Aluminum hydrogen sulfate [Al(HSO4)3] as an efficient catalyst for the preparation of thioacetals
  作者：Majid Ghashang

  DOI：10.1007/s11164-012-0802-8

  日期：2013.7

  Aluminum hydrogen sulfate, as a heterogeneous solid acid catalyst, has been used for the mild conversion of carbonyl compounds to their thioacetals using 1,2- and 1,3-dithiol under ambient conditions with short reaction times in high to excellent yield in acetonitrile as solvent.

  硫酸氢铝作为一种非均相固体酸催化剂，已被用于在环境条件下使用1,2-和1,3-二硫醇将羰基化合物温和地转化为其硫缩醛，反应时间短，在乙腈中的转化率高至优异。溶剂。
• Visible-light promoted dithioacetalization of aldehydes with thiols under aerobic and photocatalyst-free conditions
  作者：Zhimin Xing、Mingyang Yang、Haiyu Sun、Zemin Wang、Peng Chen、Lin Liu、Xiaolei Wang、Xingang Xie、Xuegong She

  DOI：10.1039/c8gc02237b

  日期：——

  A novel photocatalyst-free visible-light-mediated dithioacetalization of aldehydes and thiols has been developed.

  一种新型的无光催化剂可见光介导的醛和硫醇的二硫缩合反应已经被开发。
• A RAPID AND EFFICIENT METHOD OF THIOACETALIZATION OF CARBONYL COMPOUNDS CATALYSED BY POCl₃-MONTMORILLNITE
  作者：Tong-Shou Jin、Xu Sun、Yan-Ran Ma、Tong-Shuang Li

  DOI：10.1081/scc-100103985

  日期：2001.1

  Aldehydes and ketones were thioactalized with 1,2- ethanedithiol in the presence POCl3-montmorillonite at room temperature in excellent yields.

  醛和酮在室温下在 POCl3-蒙脱石存在下用 1,2-乙二硫醇以极好的收率进行硫代缩醛化。
• Robbe; Fernandez; Dubief, European Journal of Medicinal Chemistry, 1982, vol. 17, # 3, p. 235 - 243
  作者：Robbe、Fernandez、Dubief、et al.

  DOI：——

  日期：——
• Chemoselective Dithioacetalization of Carbonyl Compounds Using Magnesium Hydrogensulfate as Efficient Heterogeneous Catalyst
  作者：Hamid Reza Shaterian、Asghar Hosseinian、Majid Ghashang、Fahimeh Khorami

  DOI：10.1080/10426500801967740

  日期：2008.9.15

  Carbonyl compounds have been successfully converted into their corresponding dithiolanes and dithianes derivatives with 1,2-ethanedithiol and 1,3-propanedithiol in excellent yield at room temperature and short reaction times using a catalytic amount of magnesium hydrogensulfate. The synthetic simple procedures reported in this paper constitute an exceptionally mild procedure for carbonyl protection in ambient conditions.