isopropyl-phenyl-diazene | 1075-73-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: isopropyl-phenyl-diazene
• 英文别名: Isopropyl-phenyl-diazen；Isopropyl-phenyl-diimid；2-Benzolazo-propan；2-Phenylazo-propan；2-Phenylazopropan；(E)-1-Phenyl-2-(propan-2-yl)diazene；phenyl(propan-2-yl)diazene
• CAS: 1075-73-6
• 化学式: C₉H₁₂N₂
• 分子量: 148.208
• InChiKey: LSRGSUHWUKKUNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  24.7
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2927000090

反应信息

• 作为产物：
  描述：

  丙酮苯腙 在 盐酸 、 Pt/Al₂O₃ 、 colloid 、 溶剂黄146 作用下， 生成 isopropyl-phenyl-diazene
  参考文献：
  名称：

  Goodwin; Bailey, Journal of the American Chemical Society, 1925, vol. 47, p. 173

  摘要：

  DOI：

文献信息

• [EN] METHOD FOR FLUORESCENCE LABELING OF BIOLOGICAL MATERIALS, THERMALLY REMOVABLE FLUORESCENT LABELS FOR THIS METHOD, AND METHODS OF THEIR PREPARATION AND USE<br/>[FR] PROCÉDÉ DE MARQUAGE PAR FLUORESCENCE DE MATÉRIAUX BIOLOGIQUES, MARQUEURS FLUORESCENTS ÉLIMINABLES PAR VOIE THERMIQUE DESTINÉS À CE PROCÉDÉ ET LEURS PROCÉDÉS DE PRÉPARATION ET D'UTILISATION
  申请人：FUTURESYNTHESIS SPOLKA Z O O

  公开号：WO2020117079A1

  公开（公告）日：2020-06-11

  The compounds (12), (13) of the invention are applied as thermosensitive fluorescent labels for labeling of biological material with fluorescent dyes used for biological, chemical or physical analyzes. Disclosed is also a method for fluorescence labeling of nucleosides, nucleotides and oligonucleotides with those fluorescent dyes characterized in that a moiety of general formula 1 or 2 or 3 or 4 with the double bond configuration E is attached to a nucleoside nucleotide or oligonucleotide.

  本发明的化合物（12），（13）被应用为热敏荧光标记物，用于使用于生物、化学或物理分析的荧光染料对生物材料进行标记。还公开了一种荧光标记核苷、核苷酸和寡核苷酸的方法，其中这些荧光染料的特征是将通式1或2或3或4的基团与具有双键构型E的核苷、核苷酸或寡核苷酸结合。
• Hydrazone derivatives and uses thereof
  申请人：Bryant W. Robert

  公开号：US20070207093A1

  公开（公告）日：2007-09-06

  The present invention is directed to the use of a compound having the formula wherein R 1 , R 2 , R 3 , R 4 , L 1 , and L 2 are defined herein. The compounds of the present invention are useful as inhibitors of certain taste perceptions and functions. The invention is also directed to compositions comprising a compound according to the above formula.

  本发明涉及使用具有以下式子的化合物，其中R1，R2，R3，R4，L1和L2在此定义。本发明的化合物可用作某些味觉感知和功能的抑制剂。本发明还涉及包含上述式子的化合物的组合物。
• Polar effects in reactions of carbon-centered radicals with diazonium salts: free-radical diazo coupling
  作者：Francesco Minisci、Fausta Coppa、Francesca Fontana、Giuseppe Pianese、Lihua Zhao

  DOI：10.1021/jo00040a038

  日期：1992.7

  Carbon-centered radicals react with diazonium salts by addition, leading under reductive conditions to azo derivatives (free-radical diazocoupling), or by electron-transfer in chain processes. The reaction is highly sensitive to polar effects and it has been investigated by three different processes: (i) alkyl radicals, generated from alkyl iodides, H2O2, Fe(II) salt, and DMSO, have been utilized to develop a new general synthesis of alkylarylazo compounds; (ii) the reaction of aryl radicals with diazonium salts in the presence of Ti(III) or Fe(II) salts has been investigated, also in relation to the fact that the reaction products (azoarenes and biaryls) are often detected as side products in classical organic reactions of diazonium salts, catalyzed by Cu(I) salts, such as the Sandmeyer, Meerwein, and Pschorr reactions; (iii) adducts from addition of aryl radicals to vinyl acetate or vinyl ether react with diazonium salts either by diazocoupling reaction or by electron-transfer; a general synthesis of [alpha-(acyl-oxy)alkyl]arylazo compounds has been developed.
• Use of a TRPM5 Inhibitor to Regulate Insulin and GLP-1 Release
  申请人：Lee S. Paul

  公开号：US20080306030A1

  公开（公告）日：2008-12-11

  The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor.
• METHOD FOR FLUORESCENCE LABELING OF BIOLOGICAL MATERIALS, THERMALLY REMOVABLE FLUORESCENT LABELS FOR THIS METHOD, AND METHODS OF THEIR PREPARATION AND USE
  申请人：FUTURESYNTHESIS SPÓLKA Z O.O.

  公开号：US20220025432A1

  公开（公告）日：2022-01-27

  A thermosensitive fluorescent label for labeling of biological material with fluorescent dyes used for biological, chemical or physical analyzes. A method for fluorescence labeling of nucleosides, nucleotides and oligonucleotides with those fluorescent dyes wherein a moiety of general formula 1 or 2 or 3 or 4 with the double bond configuration is attached to a nucleoside, nucleotide or oligonucleotide.