1,2-Dinitro-3-(trifluoromethyl)benzene | 38886-23-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,2-Dinitro-3-(trifluoromethyl)benzene
• CAS: 38886-23-6
• 化学式: C7H3F3N2O4
• 分子量: 236.1
• InChiKey: YEAOVYLCHBNHNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  91.6
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2,3-dinitrochlorobenzene 、 二溴二氟甲烷 生成 1,2-Dinitro-3-(trifluoromethyl)benzene
  参考文献：
  名称：

  CLARK, JAMES H.;MCCLINTON, MARTIN A.;JONES, CRAIG W.;LANDON, PHILIP;BISHO+, TETRAHEDRON LETT., 30,(1989) N6, C. 2133-2136

  摘要：

  DOI：

文献信息

• [EN] PROCESS FOR PRODUCING TOLUIDINE COMPOUND<br/>[FR] PROCÉDÉ DE FABRICATION D'UN COMPOSÉ DE TOLUIDINE
  申请人：ISHIHARA SANGYO KAISHA

  公开号：WO2009054210A1

  公开（公告）日：2009-04-30

  ABSTRACT Because fluazinam is excellent as an active ingredient of pesticides and highly useful, it is desired to produce it efficiently in a proper form with simple operations at low cost in an environmentally friendly manner. The desired product is obtained in good yields with simple operations by using industrially advantageous reaction systems by a process comprising (1) a step of reacting ACTF and DCDNBTF in the presence of an alkali component, a solvent selected from the group consisting of ethers, nitriles and esters, (2) a step of neutralizing or acidifying the reaction mixture with an acid and (3) a step of removing the solvent by distillation from the mixture containing fluazinam as the reaction product and the solvent to precipitate crystals of the product.

  摘要：由于氟唑菌胺是一种优秀的杀虫剂活性成分，具有高度的实用性，因此希望以环保的方式，以低成本、简单操作的方式高效地生产它。通过使用工业上优越的反应系统，通过以下步骤获得所需产品：（1）在碱性组分和从醚、腈和酯类中选择的溶剂的存在下，反应ACTF和DCDNBTF，（2）用酸中和或加酸处理反应混合物，（3）通过蒸馏从含有氟唑菌胺反应产物和溶剂的混合物中去除溶剂，以沉淀出产品的晶体，可以简单地获得良好产率的所需产品。
• Process For the Synthesis of Organic Compounds
  申请人：Acemoglu Murat

  公开号：US20080200691A1

  公开（公告）日：2008-08-21

  The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is an intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II):

  本发明提供了一种高效、安全和成本效益的方法，用于制备5-(4-甲基-1H-咪唑-1-基)-3-(三氟甲基)-苯胺，该化合物是制备式(II)取代的嘧啶基氨基苯甲酰胺的中间体：
• [EN] SUBSTITUTED 2-ALKYLAMINE NICOTINIC AMIDE DERIVATIVES AND USE THERE OF<br/>[FR] DERIVES SUBSTITUES D'AMIDE 2-ALKYLAMINE NICOTINIQUE ET UTILISATIONS ASSOCIEES
  申请人：AMGEN INC

  公开号：WO2004007458A1

  公开（公告）日：2004-01-22

  Selected amines of Formula XIII, which are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的十三号化合物，对于预防和治疗疾病，如介导血管生成的疾病具有有效性。该发明包括新的化合物、类似物、前药和药学上可接受的盐，药物组合物以及用于预防和治疗癌症等疾病和其他病症或状况的方法。该发明还涉及制造这些化合物的过程以及在这些过程中有用的中间体。
• Synthesis of bromethalin intermediate
  申请人：ELI LILLY AND COMPANY

  公开号：EP0197706A2

  公开（公告）日：1986-10-15

  The present invention provides a process for preparing N-methyl-2,4-dinitro-N-phenyl-6-(trifluoromethyl)-benzenamine comprising treating 2-chloro-3,5-dinitrobenzotrifluoride in the presence of N,N-dimethylformamide and pyridine with a fluorinating reagent to provide 2-fluoro-3,5-dinitrobenzotrifluoride, which is finally reacted with N-methylaniline.

  本发明提供了一种制备 N-甲基-2,4-二硝基-N-苯基-6-(三氟甲基)-苯胺的工艺，包括在 N,N-二甲基甲酰胺和吡啶存在下，用氟化试剂处理 2-氯-3,5-二硝基三氟甲苯，得到 2-氟-3,5-二硝基三氟甲苯，最后与 N-甲基苯胺反应。
• Novel bis m-benzotrifluoride compounds
  申请人：OCCIDENTAL CHEMICAL CORPORATION

  公开号：EP0413194A1

  公开（公告）日：1991-02-20

  Disclosed are bis-meta-benzotrifluoride compounds having the general formula where each A is independently selected from the group consisting of NO₂, NH₂, and NH₃⁺Z⁻, Z⁻ is an anion, and B is selected from the group consisting of O, CO, S, SO, and SO₂. The diamine compounds are useful as monomers in making polyimides, polyamide-imides, and polyamides.

  所公开的双-间三氟甲苯化合物通式如下 其中每个 A 独立地选自由 NO₂、NH₂ 和 NH₃⁺Z-，Z- 是阴离子，B 选自由 O、CO、S、SO 和 SO₂ 组成的组。二胺化合物可用作制造聚酰亚胺、聚酰胺-酰亚胺和聚酰胺的单体。