1-(2,6-dimethylphenylamino)-propan-2-ol | 50563-68-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2,6-dimethylphenylamino)-propan-2-ol
• 英文别名: N-(β-hydroxypropyl)-2,6-dimethyl-aniline；N-(2'-hydroxypropyl)-2,6-xylidine；N-(β-Hydroxypropyl)-2,6-dimethyl-anilin；N-(2'-Hydroxy-propyl)-2,6-dimethyl-anilin；1-(2,6-Dimethylanilino)propan-2-ol
• CAS: 50563-68-3
• 化学式: C₁₁H₁₇NO
• 分子量: 179.262
• InChiKey: NSMNHUXUNWOYTG-UHFFFAOYSA-N

物化性质

• 沸点：
  321.5±27.0 °C(Predicted)
• 密度：
  1.040±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2,6-dimethylphenylamino)-propan-2-ol 在 三溴化磷 、 potassium iodide 作用下， 以 氯仿 为溶剂， 生成 1-(2',6'-Dimethylphenyl)-2-phenyl-amino-propan
  参考文献：
  名称：

  DD143255

  摘要：

  公开号：
• 作为产物：
  描述：

  溶剂紫36 、 2,6-二甲基苯胺 在 sodium hydroxide 作用下， 以 甲苯 为溶剂， 生成 1-(2,6-dimethylphenylamino)-propan-2-ol
  参考文献：
  名称：

  2-Chloro-N-(2'-methoxypropyl)- and

  摘要：

  2-氯-N-(2'-甲氧基丙基)-和2-氯-N-(2'-乙氧基丙基)-2",6"-二甲基乙酰苯胺是非常有效的除草剂和植物生长调节剂，具有土壤中改善的稳定性。

  公开号：

  US04412855A1

文献信息

• 1,3-Diaryl-2-imino-imidazolidines and compositions thereof
  申请人：Egyt Gyogyszervegyeszeti Gyar

  公开号：US04284642A1

  公开（公告）日：1981-08-18

  The invention relates to new compounds of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.5 each represent a phenyl group, optionally substituted, R.sup.2 stands for hydrogen, formyl group, carboxy group, lower alkoxycarbonyl group, hydroxy-(lower)-alkoxycarbonyl group, or a lower alkyl group, optionally substituted, R.sup.3 and R.sup.4 each represent hydrogen atom or a lower alkyl group, with the proviso that when R.sup.1 and R.sup.5 each represent a phenyl group, R.sup.2 and R.sup.3 may not stand for hydrogen. These compounds possess valuable biological properties, and can be applied primarily as antiphlogistic or diuretic agents.

  该发明涉及具有一般式（I）的新化合物，其中R1和R5分别代表苯基，可选择性地取代，R2代表氢、甲酰基、羧基、较低的烷氧羰基、羟基-(较低)-烷氧羰基或较低的烷基，可选择性地取代，R3和R4分别代表氢原子或较低的烷基，但当R1和R5分别代表苯基时，R2和R3不能代表氢。这些化合物具有有价值的生物学性质，主要可用作抗炎或利尿剂。
• 1,3-Diaryl-2-imino-imidazolidines and compounds
  申请人：EGYT Gyogyszervegyeszeti Gyar

  公开号：US04369325A1

  公开（公告）日：1983-01-18

  A compound of the general formula (I), ##STR1## is described wherein R.sup.1 and R.sup.5 each represent a phenyl group optionally substituted with 1 to 3 lower alkoxy, halo, lower alkyl, monohalo-(lower)-alkyl, dihalo-(lower)-alkyl and/or trihalo-(lower)-alkyl groups, R.sup.2 stands for hydrogen or a lower alkyl group optionally substituted with a hydroxy group or 1 to 3 halogen atoms, R.sup.3 and R.sup.4 each represent a hydrogen atom or a lower alkyl group, and R.sup.6 stands for a carbamoyl, thiocarbamoyl or amidino group having optionally one or two lower alkyl and/or lower alkoxycarbonyl substitutes, or a group of the general formula R.sup.7 -CO-wherein R.sup.7 stands for a lower analkoxy group, an aryloxy group, or an aralkoxy group, and n is equal to 0, provided that when R.sup.1 and R.sup.5 each represent a phenyl group, R.sup.2 and R.sup.3 may not stand for hydrogen or a pharmaceutically acceptable acid addition salt, a pure isomer or an isomeric mixture thereof. The compounds posses antiphlogistic and diuretic activity.

  描述了一种具有一般式（I）的化合物，其中R.sup.1和R.sup.5分别代表一个苯基，可选地取代1到3个较低的烷氧基，卤素，较低的烷基，单卤代（较低）烷基，双卤代（较低）烷基和/或三卤代（较低）烷基基团，R.sup.2代表氢或一个较低的烷基，可选地取代一个羟基或1到3个卤素原子，R.sup.3和R.sup.4分别代表氢原子或较低的烷基，R.sup.6代表一个氨基甲酰基，硫脲基或氨基甲酸基，其中具有可选的一个或两个较低的烷基和/或较低的烷氧羰基取代，或者具有一般式R.sup.7-CO-的基团，其中R.sup.7代表一个较低的烷氧基，芳基氧基，或芳基烷氧基，n等于0，但当R.sup.1和R.sup.5各自代表苯基时，R.sup.2和R.sup.3不能代表氢原子或一种药学上可接受的酸加成盐，纯异构体或异构体混合物。这些化合物具有抗炎和利尿作用。
• Zubovics; Toldy; Varro, European Journal of Medicinal Chemistry, 1986, vol. 21, # 5, p. 370 - 378
  作者：Zubovics、Toldy、Varro、et al.

  DOI：——

  日期：——
• Synthesis and styrene polymerization behavior of new titanium complexes Cp*TiCl(OCHRCH2NAr)
  作者：Jie Chen、Yue-Sheng Li、Ji-Qian Wu、Ning-Hai Hu

  DOI：10.1016/j.molcata.2005.01.007

  日期：2005.5

  A series of titanium complexes (CpTiCl)-Ti-*(OCHRCH2NAr) (CP* = C5Me5, R = H, Ar = phenyl (2a); R = H, Ar = 2,6-dimethylphenyl (2b); R = Me, Ar = phenyl (2c); R = Me, At = 2,6-dimethylphenyl (2d)) was prepared by the reaction of corresponding 2-phenylamino-ethanol derivatives with (CpTiCl3)-Ti-* in the presence of excessive triethylamine. All the titanium complexes display higher catalytic activity towards the syndiospecific polymerization of styrene in the presence of modified methylaluminoxane (MMAO) as a cocatalyst, yielding higher molecular weight polystyrenes with higher syndiotacticities and melting temperatures (T-m) than their mother complex (CpTiCl3)-Ti-*. When 2-(2,6-diisopropyl-phenylamino)-ethanol was reacted with (CpTiCl3)-Ti-*, an unexpected monodentate complex (CpTiCl2)-Ti-*((OCH2CH2NHC6H3Pr2)-Pr-i-2,6) 3 was obtained. The complex 3 displays relative low catalytic activity towards styrene polymerization, but produces higher molecular weight polystyrene with higher syndiotacticities. (c) 2005 Elsevier B.V. All rights reserved.
• ZUBOVICS Z.; TOLDY L.; VARRO A.; RABLOCZKY G.; KURTHY M.; DVORTSAK P.; JE+, EUR. J. MED. CHEM., 21,(1986) N 5, 370-378
  作者：ZUBOVICS Z.、 TOLDY L.、 VARRO A.、 RABLOCZKY G.、 KURTHY M.、 DVORTSAK P.、 JE+

  DOI：——

  日期：——