(E)-5-(4-hydroxybenzylidene)imidazolidine-2,4-dione | 80171-33-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (E)-5-(4-hydroxybenzylidene)imidazolidine-2,4-dione
• 英文别名: 5-(p-hydroxybenzylidene)hydantoin；hemimycalin C；5-(4-hydroxy-benzylidene)-imidazolidine-2,4-dione；5-(4-Hydroxy-benzyliden)-imidazolidin-2,4-dion；5-(4-Hydroxy-benzyliden)-hydantoin；(5E)-5-[(4-hydroxyphenyl)methylidene]imidazolidine-2,4-dione
• CAS: 80171-33-1
• 化学式: C₁₀H₈N₂O₃
• 分子量: 204.185
• InChiKey: UPDDIBZITPTASO-VMPITWQZSA-N

物化性质

• 熔点：
  316-318℃

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  (E)-5-(4-hydroxybenzylidene)imidazolidine-2,4-dione 在 sodium hydroxide 作用下， 生成 4-羟苯基丙酮酸
  参考文献：
  名称：

  Billek, Organic syntheses. Collective volume, 1973, vol. V, p. 627

  摘要：

  DOI：
• 作为产物：
  描述：

  (Z)-5-(4-hydroxybenzylidene)-2-thioxoimidazolidin-4-one 在 氯乙酸 作用下， 生成 (E)-5-(4-hydroxybenzylidene)imidazolidine-2,4-dione
  参考文献：
  名称：

  Boyd; Robson, Biochemical Journal, 1935, vol. 29, p. 546,549

  摘要：

  DOI：

文献信息

• NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR
  申请人：Chung Hae Young

  公开号：US20140023603A1

  公开（公告）日：2014-01-23

  Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

  提供了一种具有美白皮肤、抗氧化和PPAR活性的新化合物及其医疗用途，该化合物具有美白皮肤的活性，可抑制酪氨酸酶，因此适用于用于美白皮肤的药物组合物或化妆品；具有抗氧化活性，因此适用于预防和治疗皮肤老化；具有PPAR活性，特别是PPARα和PPARγ活性，因此适用于用于预防和治疗肥胖、代谢性疾病或心血管疾病的药物组合物或保健食品。
• Benzylidene hydantoin derivative, ultraviolet ray absorbent and external preparation for skin including the same
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0632029A1

  公开（公告）日：1995-01-04

  A benzylidene hydantoin derivative represented by the following formula (1). (In the formula, R¹ represents a straight or branched alkyl group having 1-8 carbon atoms and R² represents a branched alkyl group having 5-18 carbon atoms.) The derivative has excellent UV-A absorptivity and usability.

  由以下公式（1）表示的苄亚甲基咪唑啉衍生物。 （在公式中，R¹代表具有1-8个碳原子的直链或支链烷基基团，R²代表具有5-18个碳原子的支链烷基基团。）该衍生物具有优异的UV-A吸收性和可用性。
• Process for the preparation of new antidiabetic agents
  申请人：DR. REDDY'S LABORATORIES LIMITED

  公开号：US20030125553A1

  公开（公告）日：2003-07-03

  The present invention relates to an improved process for the preparation of novel antidiabetic compounds having formula (1) where R 1 represents hydrogen or lower alkyl group and X represents hydrogen or halogen atom. 1

  本发明涉及一种改进的制备新型抗糖尿病化合物的方法，其化学式为（1），其中R1代表氢或较低的烷基团，X代表氢或卤素原子。
• NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREOF
  申请人：Pusan National University Industry-University Cooperation Foundation

  公开号：US20160102065A1

  公开（公告）日：2016-04-14

  Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

  提供了一种具有美白、抗氧化和PPAR活性的新化合物及其医疗用途。该化合物具有抑制酪氨酸酶的美白活性，因此可用于美白药物组合物或化妆品产品；具有抗氧化活性，因此可用于预防和治疗皮肤老化；具有PPAR活性，特别是PPARα和PPARγ活性，因此可用于有效预防和治疗肥胖症、代谢疾病或心血管疾病的药物组合物或保健食品。
• Verfahren zur Herstellung von 5-Arylidenhydantoinen (B)
  申请人：Degussa Aktiengesellschaft

  公开号：EP0037479A1

  公开（公告）日：1981-10-14

  5-Arylidenhydantoine werden durch Kondensation von aromatischen Aldehyden mit Hydantoin in Gegenwart mindestens eines Ammoniumsalzes einer aliphatischen oder aromatischen Carbonsäure hergestellt. Die gewünschten 5-Arylidenhydantoinewerden in hohen Ausbeuten erhalten.

  在至少一种脂肪族或芳香族羧酸的铵盐存在下，通过芳香醛与海因的缩合制备 5-芳基海因。可以高产率获得所需的 5-芳基亚甲基海因。