[4-(5,6-Dihydroimidazo[2,1-b][1,3]thiazol-3-yl)phenyl]-phenylmethanone | 1134395-07-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [4-(5,6-Dihydroimidazo[2,1-b][1,3]thiazol-3-yl)phenyl]-phenylmethanone
• CAS: 1134395-07-5
• 化学式: C₁₈H₁₄N₂OS
• 分子量: 306.388
• InChiKey: ARGZJMTXHQTSRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  58
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [4-(5,6-Dihydroimidazo[2,1-b][1,3]thiazol-3-yl)phenyl]-phenylmethanone 在 N-碘代丁二酰亚胺 作用下， 以 乙腈 为溶剂， 反应 2.0h， 以32%的产率得到
  参考文献：
  名称：

  Synthesis and evaluation of photoreactive probes to elucidate iodide efflux in thyrocytes

  摘要：

  Four photoreactive analogues of 3-biphenyl-40-yl-5,6-dihydroimidazo[2,1-b]thiazole were prepared and evaluated as iodide sequestering agents in sodium iodide symporter-expressing cells. One of these new photoactivatable compounds retained biological activity and was further radiolabeled with tritium. This compound may provide a useful tool for labeling, purification, and identification of target protein responsible for iodide efflux in thyrocytes. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.12.008
• 作为产物：
  描述：

  在 palladium 10% on activated carbon 、 氢气 、 三乙胺 作用下， 以 甲醇 为溶剂， 20.0 ℃ 、182.4 kPa 条件下， 反应 12.0h， 以98%的产率得到[4-(5,6-Dihydroimidazo[2,1-b][1,3]thiazol-3-yl)phenyl]-phenylmethanone
  参考文献：
  名称：

  Synthesis and evaluation of photoreactive probes to elucidate iodide efflux in thyrocytes

  摘要：

  Four photoreactive analogues of 3-biphenyl-40-yl-5,6-dihydroimidazo[2,1-b]thiazole were prepared and evaluated as iodide sequestering agents in sodium iodide symporter-expressing cells. One of these new photoactivatable compounds retained biological activity and was further radiolabeled with tritium. This compound may provide a useful tool for labeling, purification, and identification of target protein responsible for iodide efflux in thyrocytes. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.12.008

文献信息

• Synthesis and evaluation of photoreactive probes to elucidate iodide efflux in thyrocytes
  作者：Séverine Derbré、Nathalie Lecat-Guillet、Florence Pillon、Yves Ambroise

  DOI：10.1016/j.bmcl.2008.12.008

  日期：2009.2

  Four photoreactive analogues of 3-biphenyl-40-yl-5,6-dihydroimidazo[2,1-b]thiazole were prepared and evaluated as iodide sequestering agents in sodium iodide symporter-expressing cells. One of these new photoactivatable compounds retained biological activity and was further radiolabeled with tritium. This compound may provide a useful tool for labeling, purification, and identification of target protein responsible for iodide efflux in thyrocytes. (C) 2008 Elsevier Ltd. All rights reserved.