3-[4-[3-(Trifluoromethyl)diazirin-3-yl]phenyl]-5,6-dihydroimidazo[2,1-b][1,3]thiazole | 1134395-08-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[4-[3-(Trifluoromethyl)diazirin-3-yl]phenyl]-5,6-dihydroimidazo[2,1-b][1,3]thiazole
• CAS: 1134395-08-6
• 化学式: C₁₃H₉F₃N₄S
• 分子量: 310.302
• InChiKey: ZKBAQDHSJOGWRO-UHFFFAOYSA-N

物化性质

• 沸点：
  397.2±52.0 °C(predicted)
• 密度：
  1.66±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  65.6
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  亚乙基硫脲 、 1-(4-(3-(trifluoromethyl)-3H-diazirin-3-yl)phenyl)ethanone 在 碘 作用下， 以 乙醇 为溶剂， 反应 8.0h， 以48%的产率得到3-[4-[3-(Trifluoromethyl)diazirin-3-yl]phenyl]-5,6-dihydroimidazo[2,1-b][1,3]thiazole
  参考文献：
  名称：

  Synthesis and evaluation of photoreactive probes to elucidate iodide efflux in thyrocytes

  摘要：

  Four photoreactive analogues of 3-biphenyl-40-yl-5,6-dihydroimidazo[2,1-b]thiazole were prepared and evaluated as iodide sequestering agents in sodium iodide symporter-expressing cells. One of these new photoactivatable compounds retained biological activity and was further radiolabeled with tritium. This compound may provide a useful tool for labeling, purification, and identification of target protein responsible for iodide efflux in thyrocytes. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.12.008

文献信息

• Synthesis and evaluation of photoreactive probes to elucidate iodide efflux in thyrocytes
  作者：Séverine Derbré、Nathalie Lecat-Guillet、Florence Pillon、Yves Ambroise

  DOI：10.1016/j.bmcl.2008.12.008

  日期：2009.2

  Four photoreactive analogues of 3-biphenyl-40-yl-5,6-dihydroimidazo[2,1-b]thiazole were prepared and evaluated as iodide sequestering agents in sodium iodide symporter-expressing cells. One of these new photoactivatable compounds retained biological activity and was further radiolabeled with tritium. This compound may provide a useful tool for labeling, purification, and identification of target protein responsible for iodide efflux in thyrocytes. (C) 2008 Elsevier Ltd. All rights reserved.