Pentafluorbenzoylperoxyd | 71208-93-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Pentafluorbenzoylperoxyd
• 英文别名: Pentafluoroperbenzoic acid；2,3,4,5,6-pentafluorobenzenecarboperoxoic acid
• CAS: 71208-93-0
• 化学式: C₇HF₅O₃
• 分子量: 228.075
• InChiKey: LOTAHYLSRQBDBO-UHFFFAOYSA-N

物化性质

• 沸点：
  292.3±50.0 °C(Predicted)
• 密度：
  1.762±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  双金刚烷 、 Pentafluorbenzoylperoxyd 在 MoO₃*2C₉H₇NO 作用下， 以 二氯甲烷 、 1,2-二氯乙烷 为溶剂， 反应 12.0h， 以50%的产率得到diamantan-1-yl 2,3,4,5,6-pentafluorobenzoate
  参考文献：
  名称：

  Selective hydroxylation of diamantane with 2,3,4,5,6-pentafluoroperbenzoic acid in the presence of molibdenum complexes

  摘要：

  Oxidation of diamantane with 2,3,4,5,6-pentafluoroperbenzoic acid catalyzed with complexes MoO(O-2)center dot 2QOH, MoO(O-2)(H2O)(2) proceeds selectively affording diamantan-1-ol and diamantan-1-yl 2,3,4,5,6-pentafluorobenzoate.

  DOI：

  10.1134/s1070428016080054
• 作为产物：
  描述：

  五氟苯甲醛 在 氧气 、 臭氧 作用下， 以 四氯化碳 为溶剂， 反应 3.0h， 以80%的产率得到Pentafluorbenzoylperoxyd
  参考文献：
  名称：

  Pentafluoroperoxybenzoic acid ? A new highly active and stable oxidizing reagent

  摘要：

  DOI：

  10.1007/bf00950292
• 作为试剂：
  描述：

  双金刚烷 在 Pentafluorbenzoylperoxyd 、 MoO₃*2H₂O 、 sodium acetate 作用下， 以 二氯甲烷 、 1,2-二氯乙烷 为溶剂， 反应 6.0h， 以71%的产率得到diamantan-1-ol
  参考文献：
  名称：

  Selective hydroxylation of diamantane with 2,3,4,5,6-pentafluoroperbenzoic acid in the presence of molibdenum complexes

  摘要：

  Oxidation of diamantane with 2,3,4,5,6-pentafluoroperbenzoic acid catalyzed with complexes MoO(O-2)center dot 2QOH, MoO(O-2)(H2O)(2) proceeds selectively affording diamantan-1-ol and diamantan-1-yl 2,3,4,5,6-pentafluorobenzoate.

  DOI：

  10.1134/s1070428016080054

文献信息

• RESIST COMPOSITION CONTAINING NOVEL SULFONIUM COMPOUND, PATTERN-FORMING METHOD USING THE RESIST COMPOSITION, AND NOVEL SULFONIUM COMPOUND
  申请人：KAMIMURA Sou

  公开号：US20090042124A1

  公开（公告）日：2009-02-12

  A resist composition includes (A) a compound represented by the following formula (I): wherein each of R 1 to R 13 independently represents a hydrogen atom or a substituent, provided that at least one of R 1 to R 13 is a substituent containing an alcoholic hydroxyl group; Z represents a single bond or a divalent linking group; and X − represents an anion containing a proton acceptor functional group.

  一种抗性组合物包括(A)由以下公式（I）所代表的化合物：其中R1至R13中的每一个独立地代表氢原子或取代基，前提是R1至R13中至少有一个是含有醇羟基的取代基；Z代表单键或二价连接基团；X-代表含有质子受体功能基团的阴离子。
• 1,3-Benzoxazine derivatives, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0477789A1

  公开（公告）日：1992-04-01

  A new compound of the formula: wherein is an optionally substituted benzene ring; R1 is a carbocyclic or heterocyclic group which is linked to the 4- position of the 1,3-benzoxazine ring through a carbon-carbon bond, a hydrocarbon residue, etc.; and R2 and R3 are independently a hydrogen atom or an optionally substituted C1 -6 alkyl group, etc., or a salt thereof is useful for treating and preventing heart, circulatory, respiratory and cerebral diseases.

  一种新的化合物，其化学式为：其中，X为可选取代的苯环；R1为与1,3-苯并噁嗪环的4-位置通过碳-碳键、烃基残基等连接的环烷基或杂环基；R2和R3分别为氢原子或可选取代的C1-6烷基等，或其盐。该化合物可用于治疗和预防心脏、循环、呼吸和脑部疾病。
• Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
  申请人：Gallop A. Mark

  公开号：US20050222431A1

  公开（公告）日：2005-10-06

  Methods for synthesis of 1 -(acyloxy)-alkyl carbamates, particularly, the synthesis of 1 -(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1 -(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1 -(acyloxy)-alkyl carbamates are also described.

  本文介绍了合成1-(酰氧基)-烷基氨基甲酸酯的方法，特别是合成含有一级或二级胺类药物的1-(酰氧基)-烷基氨基甲酸酯前药的方法。同时还介绍了合成1-(酰氧基)-烷基N-羟基琥珀酰亚胺碳酸酯的方法，这些化合物是合成1-(酰氧基)-烷基氨基甲酸酯的有用中间体。
• Methods for synthesis of acyloxyalkyl compounds
  申请人：Bhat Laxminarayan

  公开号：US20050070715A1

  公开（公告）日：2005-03-31

  Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up.

  本文公开了一种通过在无水反应条件下氧化药物的1-酰基-烷基衍生物来合成药物的1-(酰氧基)-烷基前药衍生物的方法。该方法通常具有立体选择性，产率高，不需要使用活性中间体和/或有毒化合物，并且容易扩大规模。
• Synthesis of Acyloxyalkyl Carbamate Prodrugs and Intermediates Thereof
  申请人：Gallop Mark A.

  公开号：US20090216037A1

  公开（公告）日：2009-08-27

  Methods for synthesis of 1 -(acyloxy)-alkyl carbamates, particularly, the synthesis of 1 -(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1 -(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

  本文描述了合成1-(酰氧基)-烷基氨基甲酸酯的方法，特别是合成含有一级或二级胺药物的1-(酰氧基)-烷基氨基甲酸酯前药的方法。同时还描述了合成1-(酰氧基)-烷基N-羟基琥珀酰亚胺基碳酸酯的方法，这些中间体在合成1-(酰氧基)-烷基氨基甲酸酯中非常有用。