2-Furylmethylcarbamodithioic acid | 45815-80-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-Furylmethylcarbamodithioic acid
• 英文别名: furan-2-ylmethylcarbamodithioic acid
• CAS: 45815-80-3
• 化学式: C₆H₇NOS₂
• 分子量: 173.3
• InChiKey: CTWFQNNUJKTUTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  58.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• HETEROARYL (ALKYL) DITHIOCARBAMATE COMPOUNDS, PREPARATION METHODS AND USES THEREOF
  申请人：Peking University

  公开号：EP2562157A1

  公开（公告）日：2013-02-27

  Heteroaryl (alkyl) dithiocarbamate compounds represented by general formula (I) or their pharmaceutically acceptable salts, their preparing methods, and their uses for preparing antitumor medicines are disclosed, wherein each said substituent is defined as in the description. The compounds are new tyrosine kinase inhibitors useful as an anti-tumor agents, preferably useful in the preparation of medicines for treating breast cancer, liver cancer, non-small cell lung cancer, gastric cancer, colon cancer, leukaemia or nasal cancer.

  本发明公开了通式(I)代表的杂芳基（烷基）二硫代氨基甲酸酯化合物或它们的药学上可接受的盐、它们的制备方法以及它们在制备抗肿瘤药物中的用途，其中每个所述取代基的定义如说明书中所述。 这些化合物是新的酪氨酸激酶抑制剂，可用作抗肿瘤药物，优选用于制备治疗乳腺癌、肝癌、非小细胞肺癌、胃癌、结肠癌、白血病或鼻癌的药物。
• Antioxidant enhancement of therapy for hyperproliferative conditions
  申请人：——

  公开号：US20010049349A1

  公开（公告）日：2001-12-06

  A method to enhance the cytotoxic activity of an antineoplastic drug comprising administering an effective amount of the antineoplastic drug to a host exhibiting abnormal cell proliferation in combination with an effective cytotoxicity-increasing amount of an antioxidant. The invention also includes a method to decrease the toxicity to an antineoplastic agent or increase the therapeutic index of an antineoplastic agent administered for the treatment of a solid growth of abnormally proliferating cells, comprising administering an antioxidant prior to, with, or following the antineoplastic treatment.

  一种增强抗肿瘤药物的细胞毒性活性的方法，包括向出现异常细胞增殖的宿主施用有效量的抗肿瘤药物，同时施用有效量的增加细胞毒性的抗氧化剂。本发明还包括一种降低抗肿瘤药物毒性或提高治疗异常增殖细胞实体生长的抗肿瘤药物治疗指数的方法，包括在抗肿瘤治疗之前、同时或之后施用抗氧化剂。
• TREATMENT OF DAMAGED BONE MARROW AND DOSAGE UNITS THEREFOR
  申请人：THE UNIVERSITY OF ROCHESTER

  公开号：EP0433393B1

  公开（公告）日：1995-03-15
• EP0433393A4
  申请人：——

  公开号：EP0433393A4

  公开（公告）日：1992-01-15
• USE OF DIANHYDROGALACTITOL AND ANALOGS AND DERIVATIVES THEREOF TO TREAT RECURRENT MALIGNANT GLIOMA OR PROGRESSIVE SECONDARY BRIAN TUMOR
  申请人：Del Mar Pharmaceuticals

  公开号：EP3003321A2

  公开（公告）日：2016-04-13