5-(butylthio)-1-(8-(pentylthio)octyl)-1H-tetrazole | 1426822-60-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 5-(butylthio)-1-(8-(pentylthio)octyl)-1H-tetrazole
• 英文别名: 5-Butylsulfanyl-1-(8-pentylsulfanyloctyl)tetrazole；5-butylsulfanyl-1-(8-pentylsulfanyloctyl)tetrazole
• CAS: 1426822-60-7
• 化学式: C₁₈H₃₆N₄S₂
• 分子量: 372.643
• InChiKey: LSZZIEJIZVLCFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  24
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  94.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  8-(5-tosyl-1H-tetrazol-1-yl)octyl 4-methylbenzenesulfonate 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 生成 5-(butylthio)-1-(8-(pentylthio)octyl)-1H-tetrazole
  参考文献：
  名称：

  Chemical tagging of a drug target using 5-sulfonyl tetrazole

  摘要：

  Irreversible modification is one of the most promising strategies to identify cellular receptors of bioactive small molecules. Here we report that receptor proteins can be chemically tagged using a 5-sulfonyl tetrazole probe. 5-Sulfonyl tetrazole easily accepted nucleophilic attack of thiol groups, while 5-sulfinyl tetrazole did not. These functional groups were introduced into probe molecules of a natural product. Cyclosporine A, an immunosuppressant produced by a microbe, was derivatized to possess 5-sulfonyl tetrazole and a tag group, which enabled chemical tagging of cyclophilin A, the cellular receptor of cyclosporine A. Cyclosporine A derivative possessing 5-sulfinyl tetrazole could not tag cyclophilin A. This technique will allow efficient identification of cellular receptors of bioactive small molecules. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.01.092

文献信息

• Chemical tagging of a drug target using 5-sulfonyl tetrazole
  作者：Satsuki Otsuki、Shinichi Nishimura、Hisae Takabatake、Kozue Nakajima、Yasuaki Takasu、Toru Yagura、Yuki Sakai、Akira Hattori、Hideaki Kakeya

  DOI：10.1016/j.bmcl.2013.01.092

  日期：2013.3

  Irreversible modification is one of the most promising strategies to identify cellular receptors of bioactive small molecules. Here we report that receptor proteins can be chemically tagged using a 5-sulfonyl tetrazole probe. 5-Sulfonyl tetrazole easily accepted nucleophilic attack of thiol groups, while 5-sulfinyl tetrazole did not. These functional groups were introduced into probe molecules of a natural product. Cyclosporine A, an immunosuppressant produced by a microbe, was derivatized to possess 5-sulfonyl tetrazole and a tag group, which enabled chemical tagging of cyclophilin A, the cellular receptor of cyclosporine A. Cyclosporine A derivative possessing 5-sulfinyl tetrazole could not tag cyclophilin A. This technique will allow efficient identification of cellular receptors of bioactive small molecules. (C) 2013 Elsevier Ltd. All rights reserved.