<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl>amine | 123642-58-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: <1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl>amine
• 英文别名: 1-(4,5-Dimethoxy-2-nitrophenyl)ethan-1-amine；1-(4,5-dimethoxy-2-nitrophenyl)ethanamine
• CAS: 123642-58-0
• 化学式: C₁₀H₁₄N₂O₄
• 分子量: 226.232
• InChiKey: ONBRTTJWXACSMF-UHFFFAOYSA-N

物化性质

• 沸点：
  380.2±42.0 °C(Predicted)
• 密度：
  1.212±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  90.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  <1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl>amine 在 盐酸 、 1,8-双二甲氨基萘 作用下， 以 乙酸乙酯 、 乙腈 为溶剂， 反应 15.75h， 生成 amino>ethanoic acid hydrochloride
  参考文献：
  名称：

  Synthesis of photolabile precursors of amino acid neurotransmitters

  摘要：

  DOI：

  10.1021/jo00292a038
• 作为产物：
  描述：

  1-(4,5-二甲氧基-2-硝基苯基)乙酮 在 ammonium acetate 、 sodium cyanoborohydride 作用下， 以 甲醇 为溶剂， 以23.6%的产率得到<1-(4',5'-dimethoxy-2'-nitrophenyl)ethyl>amine
  参考文献：
  名称：

  Synthesis of photolabile precursors of amino acid neurotransmitters

  摘要：

  DOI：

  10.1021/jo00292a038

文献信息

• HETEROCYCLYC SULFONAMIDES HAVING EDG-1 ANTAGONISTIC ACTIVITY
  申请人：Grewal Gurmit

  公开号：US20100029643A1

  公开（公告）日：2010-02-04

  The invention relates to chemical compounds of formula (I), (Ia) and (Ib) or pharmaceutically acceptable salts thereof, which possess Edg-1 antagonistic activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an anti-cancer effect in a warm-blooded animal, such as man.

  该发明涉及化学式（I），（Ia）和（Ib）或其药学上可接受的盐的化合物，其具有Edg-1拮抗活性，因此在抗癌活性和人或动物体的治疗方法中有用。该发明还涉及制造上述化学化合物的过程，含有它们的制药组合物以及在制造用于在温血动物（如人）中产生抗癌效果的药物的制造中使用它们。
• Chemo-enzymatic site-specific modification of peptides and proteins to form cleavable conjugates
  申请人：Northeastern University

  公开号：US11129790B2

  公开（公告）日：2021-09-28

  A method is provided for reversibly modifying a protein or peptide on its glutamine residue(s) by performing a reaction, such as a transglutaminase-catalyzed reaction, between the protein or peptide and an amine-containing reagent, whereby the reagent is linked through its amine function to a side chain of the glutamine residue. Subjecting the modified protein to an appropriate stimulus regenerates the protein or peptide in its original form.

  本发明提供了一种对蛋白质或肽的谷氨酰胺残基进行可逆修饰的方法，该方法是在蛋白质或肽与含胺试剂之间进行反应，如转谷氨酰胺酶催化反应，试剂通过其胺功能与谷氨酰胺残基的侧链相连。将修饰过的蛋白质置于适当的刺激下，蛋白质或肽就会以原来的形式再生。
• WILCOX, MAXU;VIOLA, RANDALL W.;JOHNSON, KATHERINE W.;BILLINGTON, ANDREW P+, J. ORG. CHEM., 55,(1990) N, C. 1585-1589
  作者：WILCOX, MAXU、VIOLA, RANDALL W.、JOHNSON, KATHERINE W.、BILLINGTON, ANDREW P+

  DOI：——

  日期：——
• HETEROCYCLYC SULFONAMIDES HAVING EDG-I ANTAGONISTIC ACTIVITY
  申请人：AstraZeneca AB

  公开号：EP2094670A1

  公开（公告）日：2009-09-02
• Chemo-Enzymatic Site-Specific Modification of Peptides and Proteins to Form Cleavable Conjugates
  申请人：Northeastern University

  公开号：US20180369131A1

  公开（公告）日：2018-12-27

  A method is provided for reversibly modifying a protein or peptide on its glutamine residue(s) by performing a reaction, such as a transglutaminase-catalyzed reaction, between the protein or peptide and an amine-containing reagent, whereby the reagent is linked through its amine function to a side chain of the glutamine residue. Subjecting the modified protein to an appropriate stimulus regenerates the protein or peptide in its original form.