14C-diazomethane | 13204-27-8

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 炔丙基型1，3-偶极有机化合物
• 英文名称: 14C-diazomethane
• 英文别名: diazo-[¹⁴C]methane；diazo(114C)methane
• CAS: 13204-27-8
• 化学式: CH₂N₂
• 分子量: 44.0293
• InChiKey: YXHKONLOYHBTNS-NJFSPNSNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.08
• 重原子数：
  3.0
• 可旋转键数：
  0.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  36.4
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  1,3-二氢-1,3-二氧代-2H-异吲哚-2-丙酰氯 、 14C-diazomethane 在 盐酸 作用下， 生成 2-(4-bromo-3-oxo(414C)butyl)isoindole-1,3-dione
  参考文献：
  名称：

  An approach to the design of brain-penetrating histaminergic agonists

  摘要：

  Known and novel histaminergic H-1- and H-2-receptor agonists were investigated as potentially potent and selective brain-penetrating compounds. Structural modifications were introduced in an attempt to favour passive diffusion across the blood-brain barrier by reducing hydrogen-bonding ability according to a previously developed model. While no novel compound was identified which satisfied our requirements for a brain-penetrating agonist, betahistine 14 and 2-(thiazol-2-yl)ethylamine 16 can be regarded as H-1-receptor agonists with moderate brain-penetrating ability, of potential value as pharmacological tools. A novel histamine analogue, N,N-bis-{2-[4(5)-imidazolyl]ethyl)amine 25 is reported which. although unlikely to be brain penetrant, was found to be equipotent with histamine at H-1- and H-1-receptors.

  DOI：

  10.1016/0223-5234(93)90135-2
• 作为产物：
  描述：

  Nitroso-[14C]methyl-p-toluensulfonamid 在 氢氧化钾 作用下， 以 乙醚 、 乙醇 为溶剂， 生成 14C-diazomethane
  参考文献：
  名称：

  [14C]蒽环类抗癌剂14-O-(β-alanyl-N-HCl)-7-O-(2',6'-dideoxy-2'-fluoro-α-l-talopyranosyl) adriamycinone-14-的合成14C (DA-125-14C)

  摘要：

  蒽环类抗癌剂 14-O(β-alanyl-N-HC)-7-O (2',6'-dideoxy-2'-fluoro-α-L-talopyranosyl) Adriamycinone (DA-125-14) 的合成C) 描述了用于 ADME（吸收、分布、代谢和排泄）研究的碳 14 区域特异性标记。未标记的 7-O(2',6'-dideoxy-2'-fluoro-α-L-talopyranosyl) adriamycinone (Dong-A Pharm. Lot MI-8008)(B-1) 在这九项中用作起始材料-步放射合成。14 C-标记的N-甲基-N-亚硝基-对-甲苯磺酰胺（甲基-14 C）是从 14 CH 3 I 分五步制备的，作为标记的来源。总共 335 μCi 的 14- 14 C - DA-125（比活 6.63 mCi/mmol，放射化学纯化或 98%，基于 N-甲基- 14 CN

  DOI：

  10.1002/(sici)1099-1344(199709)39:9<773::aid-jlcr21>3.0.co;2-1

文献信息

• Biosynthesis of the antitumour catharanthus alkaloids: the fate of the 21′α-hydrogen of anhydrovinblastine
  作者：Robert L. Baxter、Mashooda Hasan、Neil E. Mackenzie、A. Ian Scott

  DOI：10.1039/c39820000791

  日期：——

  [21′α-3H,methyl-14C] Anhydrovinblastine is incorporated into vinblastine by cell-free preparation of Catharanthus roseus without loss of 3H.

  [21'α- 3 H，甲基- 14 C]脱水长春碱是通过无细胞制备物掺入到长春花碱长春花不损失3 H.
• Biosynthesis of the lignans α- and β-peltatin
  作者：Widad M. Kamil、Paul M. Dewick

  DOI：10.1016/0031-9422(86)80071-1

  日期：1986.1

  aryltetralin lignans in Podophyllum peltatum has demonstrated that the major lignans α-peltatin and β-peltatin are subject to metabolic turnover. The peltatin content falls to an extremely low level during the growing season, maximum amounts being present during dormancy. Feeding experiments with labelled desoxypodophyllotoxin and 4′-demethyldesoxypodophyllotoxin indicated these compounds are the likely precursors

  摘要 Podophyllum peltatum 中抑制肿瘤的芳基四氢萘木酚素的植物化学分析表明，主要的木脂素 α-peltatin 和 β-peltatin 受到代谢转换。peltatin 含量在生长季节下降到极低的水平，在休眠期间达到最大值。用标记的脱氧鬼臼毒素和 4'-脱氧鬼臼毒素喂养实验表明，这些化合物分别是 α- 和 β-peltatins 的可能前体，通过 C-5 的芳香羟基化，证实了之前提出的建议。在 P. hexandrum 中也证明了脱氧鬼臼毒素向 β-peltatin 和鬼臼毒素的转化。
• Colchicine is formed by para-para phenol coupling from autumnaline
  作者：Ulrich H. Maier、Meinhart H. Zenk

  DOI：10.1016/s0040-4039(97)10011-9

  日期：1997.10

  In order to distinguish between ortho-para and para-para phenol coupling in colchicine biosynthesis, [3'-(OCH3)-C-14]autumnaline was converted to [C-14]colchicine in seeds of Colchicum autumnale and the product was then selectively demethylated by a bacterium that exclusively demethylates C-3 of colchicine. The retention of the radioactive label in 3-demethylcolchicine indicates that biosynthesis proceeds through para-para coupling. (C) 1997 Elsevier Science Ltd.
• Jahreis, Guenther; Smalla, Kornelia; Fittkau, Siegfried, Journal fur praktische Chemie (Leipzig 1954), 1984, vol. 326, # 1, p. 41 - 47
  作者：Jahreis, Guenther、Smalla, Kornelia、Fittkau, Siegfried

  DOI：——

  日期：——
• Winter, Werner; Moosmayer, Alfred; Rieker, Anton, Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1982, vol. 37, # 12, p. 1623 - 1632
  作者：Winter, Werner、Moosmayer, Alfred、Rieker, Anton

  DOI：——

  日期：——