1-Hexadecylpyrimidin-1-ium chloride | 58570-57-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-Hexadecylpyrimidin-1-ium chloride
• 英文别名: 1-hexadecylpyrimidin-1-ium;chloride
• CAS: 58570-57-3
• 化学式: C20H37ClN2
• 分子量: 341.0
• InChiKey: RDEMPZLHWXDAPF-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.85
• 重原子数：
  23
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  16.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• AhR mediators
  申请人：Krutmann Jean

  公开号：US20090028804A1

  公开（公告）日：2009-01-29

  The invention relates to a method for finding and assessing agonists [and] antagonists of the aryl hydrocarbon receptor (Ah receptor; AhR), to the agonists and antagonists themselves and to uses thereof.

  这项发明涉及一种用于寻找和评估芳香族羟基化合物受体（Ah受体；AhR）的激动剂和拮抗剂的方法，以及这些激动剂和拮抗剂本身及其用途。
• MENTHYL CARBAMATE COMPOUNDS AS SKIN AND/OR HAIR LIGHTENING ACTIVES
  申请人：Vielhaber Gabriele

  公开号：US20130129646A1

  公开（公告）日：2013-05-23

  The present invention relates to the cosmetic, dermatological or pharmaceutical (therapeutic) use of compounds of formula (I) or a cosmetically acceptable salt of a compound of formula (I) or a mixture containing two or more of these compounds or the salts thereof wherein R 1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R 2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R 1 and R 2 are covalently bonded to one another, preferably so that a 3 to 8 membered ring is formed, for the lightening of skin and/or hair. The invention further relates to compositions and cosmetic, dermatological or pharmaceutical preparations (compositions) comprising one or more compounds of formula (I) suitable for lightening human skin and/or hair and corresponding methods. The invention further relates to compounds of formula (I) as a drug, their use for the preparation of a pharmaceutical composition for lightening human skin and/or hair and to certain novel compounds of formula (I).

  本发明涉及化妆品、皮肤科或药用（治疗）用途的化合物的使用，其化学式为（I）或者化学式（I）的化妆品可接受的盐，或者含有两种或更多这些化合物或其盐的混合物，其中R1代表氢或具有1至14个碳原子的有机基，R2代表具有1至14个碳原子的有机基，可选地R1和R2彼此共价结合，最好形成3至8成员环，用于美白皮肤和/或头发。该发明还涉及包含一种或多种化学式（I）化合物的组合物和适用于美白人类皮肤和/或头发的化妆品、皮肤科或药用制剂（组合物）及相应的方法。该发明还涉及化学式（I）化合物作为药物，其用于制备用于美白人类皮肤和/或头发的药用组合物以及某些新的化学式（I）化合物。
• 3-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-1-propanone and its use in cosmetic and pharmaceutical preparations
  申请人：Schmaus Gerhard

  公开号：US20090208434A1

  公开（公告）日：2009-08-20

  The present invention concerns applications of the compound of formula 1 in cosmetic or pharmaceutical preparations.

  本发明涉及化合物1的在化妆品或药物制剂中的应用。
• Use of a combination of active substances containing bioquinones for the production of cosmetic or dermatological preparations
  申请人：——

  公开号：US20030180278A1

  公开（公告）日：2003-09-25

  The invention relates to the use of a compound or several compounds from the group of bioquinones a) in combination with a compound or several compounds from the group of potassium channel openers and/or b) in combination with a compound or several compounds from the group of 5-alpha-reductase inhibitors, for the production of cosmetic or dermatological preparations for treatment of the scalp and for hair in order to prolong the anagenic phase and/or for the treatment and prophylaxis of seborrhoeic symptoms, optionally by additionally using one or several compounds from the group formed from carnitine, arginine, succinic acid, folic acid, conjugated fatty acids and respectively the derivatives thereof, in addition to antioxidants.

  本发明涉及使用生物喹诺酮类化合物或多个该类化合物a）与开放钾通道剂类化合物或多个该类化合物b）与5α-还原酶抑制剂类化合物或多个该类化合物组合，用于制备用于头皮治疗和头发的化妆品或皮肤科制剂，以延长毛发生长期和/或治疗和预防皮脂溢症状，可选择性地另外使用肉碱、精氨酸、琥珀酸、叶酸、共轭脂肪酸及其衍生物中的一个或多个化合物，以及抗氧化剂。
• CYCLOHEXYL CARBAMATE COMPOUNDS AS SKIN AND/OR HAIR LIGHTENING ACTIVES
  申请人：Vielhaber Gabriele

  公开号：US20130156710A1

  公开（公告）日：2013-06-20

  The present invention relates to the cosmetic, dermatological or therapeutic use of certain cyclohexyl carbamate compounds of formula (I) given below, preferably as skin and/or hair lightening (whitening) actives. The invention further relates to compositions and cosmetic, dermatological or therapeutic products comprising one or more compounds of formula (I) suitable for lightening human skin and/or hair and corresponding methods. The invention further relates to compounds of formula (I) as a drug, their use for the preparation of a pharmaceutical composition for lightening human skin and/or hair and to novel compounds of formula (I) wherein A denotes wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR 1 , R 2 , wherein R 1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R 2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R 1 and R 2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring.

  本发明涉及以下式子(I)所示的某些环己基氨基甲酸酯化合物的化妆品、皮肤学或治疗用途，优选作为皮肤和/或头发美白活性剂。本发明还涉及含有一个或多个式(I)化合物的组合物和化妆品、皮肤学或治疗产品，适用于美白人类皮肤和/或头发以及相应的方法。本发明还涉及式(I)化合物作为药物，其用于制备用于美白人类皮肤和/或头发的制药组合物，以及式(I)的新化合物，其中A表示其中X、Y和Z彼此独立地表示氢、C1-C4烷基或C2-C4烯基，其中可选地，X、Y和Z中的两个基团在形成二环环系的情况下共价键结在一起，这样，在这样的二环环系中，X、Y和Z中的两个基团首选形成具有1到4个碳原子的基团，优选为具有1到3个碳原子的碳氢基团；B表示NR1、R2，其中R1表示氢或具有1到14个碳原子的有机基团，R2表示具有1到14个碳原子的有机基团，可选地，R1和R2彼此共价键结，优选使得B为3到8个成员的环。