[EN] COMPOUNDS FOR THE REDUCTION OF ß-AMYLOID PRODUCTION<br/>[FR] COMPOSÉS POUR LA RÉDUCTION DE LA PRODUCTION DE ß-AMYLOÏDE
申请人:BRISTOL MYERS SQUIBB CO
公开号:WO2012103297A1
公开(公告)日:2012-08-02
The present disclosure provides a series of compounds of the formula (I), which modulate β-amyloid peptide (β-ΑΡ) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-ΑΡ) production.
[EN] COMPOUNDS FOR THE REDUCTION OF ß-AMYLOID PRODUCTION<br/>[FR] COMPOSÉS DESTINÉS À LA RÉDUCTION DE LA PRODUCTION DE BETA-AMYLOÏDES
申请人:BRISTOL MYERS SQUIBB CO
公开号:WO2011014535A1
公开(公告)日:2011-02-03
The present disclosure provides a series of compounds of the formula (I) which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.
Dynamic Kinetic Resolution of γ-Substituted Cyclic β-Ketoesters via Asymmetric Hydrogenation: Constructing Chiral Cyclic β-Hydroxyesters with Three Contiguous Stereocenters
An efficient asymmetric hydrogenation of racemic γ-substituted cyclic β-ketoesters via dynamic kineticresolution to provide chiral cyclic β-hydroxy esters with threecontiguousstereocenters is reported. Using a chiral spiro iridium catalyst (R)-5 (Ir-SpiroSAP), a series of racemic γ-aryl/alkyl substituted cyclic β-ketoesters were hydrogenated to the corresponding chiral cyclic β-hydroxy esters in
COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION
申请人:Boy Kenneth M.
公开号:US20120028994A1
公开(公告)日:2012-02-02
The present disclosure provides a series of compounds of the formula (I)
which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.
Compounds for the reduction of β-amyloid production
申请人:Boy Kenneth M.
公开号:US08486952B2
公开(公告)日:2013-07-16
The present disclosure provides a series of compounds of the formula (I)
which modulate β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production.