4-Methyl-6-(1H-pyrazol-1-yl)pyrimidin-2-amine | 115930-69-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Methyl-6-(1H-pyrazol-1-yl)pyrimidin-2-amine
• 英文别名: 4-methyl-6-pyrazol-1-ylpyrimidin-2-amine
• CAS: 115930-69-3
• 化学式: C₈H₉N₅
• 分子量: 175.19
• InChiKey: GPIZNCMKTGFFGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  69.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS
  申请人：ARCUS BIOSCIENCES, INC.

  公开号：US20210101880A1

  公开（公告）日：2021-04-08

  Compound that is an inhibitor of at least one of the A 2A and A 2B adenosine receptors, and compositions containing the compound and methods for synthesizing the compound, are described herein. The use of such compound and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A 2A receptor and/or the adenosine A 2B receptor.