2-(3-fluorophenyl)-1,3-dithiolane | 83521-66-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-fluorophenyl)-1,3-dithiolane
• 英文别名: 2-(m-Fluorophenyl)-1,3-dithiolane
• CAS: 83521-66-8
• 化学式: C₉H₉FS₂
• 分子量: 200.301
• InChiKey: FUDJVIHUQFREFW-UHFFFAOYSA-N

物化性质

• 沸点：
  114 °C(Press: 1 Torr)
• 密度：
  1.283±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,2-乙二硫醇 、 3-氟苯甲醛 在 magnesium hydrogen sulfate 作用下， 以 乙腈 为溶剂， 反应 0.08h， 以94%的产率得到2-(3-fluorophenyl)-1,3-dithiolane
  参考文献：
  名称：

  Chemoselective Dithioacetalization of Carbonyl Compounds Using Magnesium Hydrogensulfate as Efficient Heterogeneous Catalyst

  摘要：

  Carbonyl compounds have been successfully converted into their corresponding dithiolanes and dithianes derivatives with 1,2-ethanedithiol and 1,3-propanedithiol in excellent yield at room temperature and short reaction times using a catalytic amount of magnesium hydrogensulfate. The synthetic simple procedures reported in this paper constitute an exceptionally mild procedure for carbonyl protection in ambient conditions.

  DOI：

  10.1080/10426500801967740

文献信息

• Robbe; Fernandez; Dubief, European Journal of Medicinal Chemistry, 1982, vol. 17, # 3, p. 235 - 243
  作者：Robbe、Fernandez、Dubief、et al.

  DOI：——

  日期：——
• Chemoselective Dithioacetalization and Oxathioacetalization of Carbonyl Compounds Using Alumina Sulfuric Acid as Catalyst
  作者：Hamid Reza Shaterian、Asghar Hosseinian、Majid Ghashang

  DOI：10.1080/00397910802272022

  日期：2008.11.3

  Carbonyl compounds have been successfully converted into their corresponding dithiolane, dithiane, and oxathiolane derivatives using a catalytic amount of alumina sulfuric acid (Al2O3-SO3H) with excellent yields at room temperature in short reaction times under mild conditions. This simple method is a highly chemoselective procedure for protection of aldehydes in the presence of ketones, and the heterogeneous catalyst can be recovered and reused several times without any loss of its activity.
• ROBBE, Y.;FERNANDEZ, J. -P.;DUBIEF, R.;CHAPAT, J. -P.;SENTENAC-ROUMANOU, +, EUR. J. MED. CHEM.-CHIM. THER., 1982, 17, N 3, 235-243
  作者：ROBBE, Y.、FERNANDEZ, J. -P.、DUBIEF, R.、CHAPAT, J. -P.、SENTENAC-ROUMANOU, +

  DOI：——

  日期：——
• Chemoselective Dithioacetalization of Carbonyl Compounds Using Magnesium Hydrogensulfate as Efficient Heterogeneous Catalyst
  作者：Hamid Reza Shaterian、Asghar Hosseinian、Majid Ghashang、Fahimeh Khorami

  DOI：10.1080/10426500801967740

  日期：2008.9.15

  Carbonyl compounds have been successfully converted into their corresponding dithiolanes and dithianes derivatives with 1,2-ethanedithiol and 1,3-propanedithiol in excellent yield at room temperature and short reaction times using a catalytic amount of magnesium hydrogensulfate. The synthetic simple procedures reported in this paper constitute an exceptionally mild procedure for carbonyl protection in ambient conditions.