bis-tris propane hydrochloride | 155379-87-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: bis-tris propane hydrochloride
• 英文别名: 2-[3-[[1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]propylamino]-2-(hydroxymethyl)propane-1,3-diol;hydrochloride；2-[3-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]propylamino]-2-(hydroxymethyl)propane-1,3-diol;hydrochloride
• CAS: 155379-87-6
• 化学式: C₁₁H₂₆N₂O₆*ClH
• 分子量: 318.798
• InChiKey: YIWFAMBMNYCKQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.59
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  145
• 氢给体数：
  9
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  D-阿拉伯糖-5-磷酸酯 、 磷烯醇丙酮酸 、 bis-tris propane hydrochloride 、 alkaline earth salt of/the/ methylsulfuric acid 在 manganese(ll) chloride 、 甲酸 、 盐酸羟胺 作用下， 反应 6.0h， 生成 3-deoxy-D-manno-2-octulosonate 8-phosphate oxime
  参考文献：
  名称：

  空肠弯曲杆菌KDO8P合酶，KDO8P肟对其的抑制以及对慢结合抑制的停留时间的控制

  摘要：

  3-脱氧d -甘露-2- octulosonate -8-磷酸盐（KDO8P）合酶催化脂多糖生物合成，即磷酸（PEP）的缩合与阿拉伯糖5-磷酸（A5P）第一步骤中，以产生KDO8P。我们已经表征了空肠弯曲杆菌KDO8P合酶及其对KDO8P肟的抑制作用。它是金属依赖性和同四聚体的，并且遵循快速平衡的顺序有序的三级动力学机理，其中首先结合了Mn 2+，然后是PEP，然后是A5P。它被KDO8P肟（3-deoxy- d - arabino的类似物）抑制-七磷酸7-磷酸（DAHP）肟，DAHP合酶的过渡态模拟物。对于Mn 2+，抑制作用是非竞争性的，而对于PEP和A5P，抑制作用是竞争性的。它既显示了快速结合抑制（K i = 10μM）又显示了缓慢结合抑制（K i * = 0.57μM）。在酶上的停留时间（t R）范围从不存在游离抑制剂的27分钟到过量抑制剂的69 h。t R的依赖关于游离抑制剂的

  DOI：

  10.1021/acs.biochem.8b00748
• 作为试剂：
  描述：

  3,4-二氯苯胺 、 丙二酰辅酶A-钠盐 在 苯磺酰胺 、 bis-tris propane hydrochloride 、 3,4-dichloroaniline-N-malonyltransferase 作用下， 反应 0.08h， 生成 N-(3,4-二氯苯基)丙二酸
  参考文献：
  名称：

  3,4-Dichloroaniline is detoxified and exported via different pathways in Arabidopsis and soybean

  摘要：

  The metabolic fate of [UL-C-14]-3,4-dichloroaniline (DCA) was investigated in Arabidopsis root cultures and soybean plants over a 48 h period following treatment via the root media. DCA was rapidly taken up by both species and metabolised, predominantly to N-malonyl-DCA in soybean and N-glucosyl-DCA in Arabidopsis. Synthesis occurred in the roots and the respective conjugates were largely exported into the culture medium, a smaller proportion being retained within the plant tissue. Once conjugated, the DCA metabolites in the medium were not then readily taken up by roots of either species. The difference in the routes of DCA detoxification in the two plants could be explained partly by the relative activities of the respective conjugating enzymes, soybean containing high DCA-N-malonyltransferase activity, while in Arabidopsis DCA-N-glucosyltransferase activity predominated. A pre-treatment of plants with DCA increased DCA-N-malonyltransferase activity in soybean but not in Arabidopsis, indicating differential regulation of this enzyme in the two plant species. This study demonstrates that DCA can undergo two distinct detoxification mechanisms which both lead to the export of conjugated, metabolites from roots into the surrounding medium in contrast to the vacuolar deposition more commonly associated with the metabolism of xenobiotics in plants. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0031-9422(03)00289-9

文献信息

• Buffered microencapsulated compositions and methods
  申请人：Latta Mark A.

  公开号：US10434044B2

  公开（公告）日：2019-10-08

  A microcapsule composition comprising at least one polymer substantially disposed as a semi-permeable shell around a buffered solution and at least one therapeutic agent, wherein the therapeutic agent permeates the shell, and wherein the composition is suitable for delivery to a mammal. This invention also provides related compositions, products and methods.

  一种微胶囊组合物，它包含至少一种聚合物，这种聚合物实质上是围绕缓冲溶液和至少一种治疗剂设置的半渗透性外壳，其中治疗剂渗透外壳，并且该组合物适用于向哺乳动物给药。本发明还提供了相关的组合物、产品和方法。
• BUFFERED MICROENCAPSULATED COMPOSITIONS AND METHODS
  申请人：Premier Dental Products Company

  公开号：EP3765036A1

  公开（公告）日：2021-01-20
• US9814657B2
  申请人：——

  公开号：US9814657B2

  公开（公告）日：2017-11-14
• [EN] BUFFERED MICROENCAPSULATED COMPOSITIONS AND METHODS<br/>[FR] COMPOSITIONS MICROENCAPSULÉES TAMPONNÉES ET MÉTHODES ASSOCIÉES
  申请人：PREMIER DENTAL PRODUCTS CO

  公开号：WO2019177927A1

  公开（公告）日：2019-09-19

  A microcapsule composition comprising at least one polymer substantially disposed as a semi-permeable shell around an aqueous buffered solution and at least one agent, wherein the agent permeates the shell, and wherein the composition is suitable for delivery to a mammal. This invention also provides related compositions, products and methods.
• <i>Campylobacter jejuni</i> KDO8P Synthase, Its Inhibition by KDO8P Oxime, and Control of the Residence Time of Slow-Binding Inhibition
  作者：Simanga R. Gama、Naresh Balachandran、Paul J. Berti

  DOI：10.1021/acs.biochem.8b00748

  日期：2018.9.11

  phosphoenolpyruvate (PEP) with arabinose 5-phosphate (A5P), to produce KDO8P. We have characterized Campylobacter jejuni KDO8P synthase and its inhibition by KDO8P oxime. It was metal-dependent and homotetrameric and followed a rapid equilibrium sequential ordered ter ter kinetic mechanism in which Mn2+ bound first, followed by PEP and then A5P. It was inhibited by KDO8P oxime, an analogue of 3-deoxy-d-arabino-heptulosonate

  3-脱氧d -甘露-2- octulosonate -8-磷酸盐（KDO8P）合酶催化脂多糖生物合成，即磷酸（PEP）的缩合与阿拉伯糖5-磷酸（A5P）第一步骤中，以产生KDO8P。我们已经表征了空肠弯曲杆菌KDO8P合酶及其对KDO8P肟的抑制作用。它是金属依赖性和同四聚体的，并且遵循快速平衡的顺序有序的三级动力学机理，其中首先结合了Mn 2+，然后是PEP，然后是A5P。它被KDO8P肟（3-deoxy- d - arabino的类似物）抑制-七磷酸7-磷酸（DAHP）肟，DAHP合酶的过渡态模拟物。对于Mn 2+，抑制作用是非竞争性的，而对于PEP和A5P，抑制作用是竞争性的。它既显示了快速结合抑制（K i = 10μM）又显示了缓慢结合抑制（K i * = 0.57μM）。在酶上的停留时间（t R）范围从不存在游离抑制剂的27分钟到过量抑制剂的69 h。t R的依赖关于游离抑制剂的