2-氧代吡咯烷-3-羧酸甲酯 | 22049-95-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 2-氧代吡咯烷-3-羧酸甲酯
• 英文名称: 2-oxo-pyrrolidine-3-carboxylic acid methyl ester
• 英文别名: methyl 2-oxopyrrolidine-3-carboxylate
• CAS: 22049-95-2
• 化学式: C₆H₉NO₃
• mdl: MFCD06254247
• 分子量: 143.142
• InChiKey: BFDDWABERUPPIN-UHFFFAOYSA-N

物化性质

• 熔点：
  136-138 °C
• 沸点：
  304.7±35.0 °C(Predicted)
• 密度：
  1.204±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H332,H335

反应信息

• 作为反应物：
  描述：

  2-氧代吡咯烷-3-羧酸甲酯 在 potassium trimethylsilonate 、 盐酸 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 0.5h， 以41.84%的产率得到2-氧代-吡咯烷-3-羧酸
  参考文献：
  名称：

  Heterobicyclic thiophene compounds and methods of use

  摘要：

  公式I的化合物及其药用盐可用于抑制受体酪氨酸激酶，并用于治疗由此介导的疾病。公开了使用公式I的化合物及其药用盐的方法，用于体外、原位和体内诊断、预防或治疗哺乳动物细胞中的这类疾病，或相关的病理情况。

  公开号：

  US20070197537A1
• 作为产物：
  描述：

  dimethyl (2-azidoethyl)malonate 以90%的产率得到
  参考文献：
  名称：

  KHOUKHI, M.;VAULTIER, M.;CARRIE, R., TETRAHEDRON LETT., 1986, 27, N 9, 1031-1034

  摘要：

  DOI：

文献信息

• IODINE-CONTAINING RADIAL-SHAPED MACROMOLECULAR COMPOUNDS, PREPARATION METHOD THEREOF AND CONTRAST MEDIA COMPOSITIONS FOR CT COMPRISING THE SOME
  申请人：Kim Yoonkyung

  公开号：US20130150529A1

  公开（公告）日：2013-06-13

  Disclosed herein is an iodine-containing radial-shaped macromolecule suitable for an active ingredient of the computed tomography (CT) contrast medium, a method to prepare the same, and a contrast medium composition including the same. With respect to the iodine-containing radial-shaped macromolecule according to the present invention, the duration of contrast enhancement has been significantly improved in comparison to that of the current small molecular contrast media compounds containing iodine.

  本文揭示了一种含碘的径向形状的大分子，适用于计算机断层扫描（CT）造影剂的活性成分，以及制备该大分子的方法，以及包括该大分子的造影剂组合物。就本发明的含碘径向形状的大分子而言，与当前含碘的小分子造影剂相比，对比增强的持续时间显著提高。
• [EN] PYRIDINYL AND PYRAZINYL-(AZA)INDOLSULFONAMIDES<br/>[FR] PYRIDINYLE ET PYRAZINYL-(AZA)INDOLSULFONAMIDES
  申请人：UCB PHARMA GMBH

  公开号：WO2019243303A1

  公开（公告）日：2019-12-26

  The present invention relates to pyridinyl and pyrazinyl-(aza)indolsulfonamides having GPR17 modulator activity. The compounds have utility in the treatment of a variety of GPR17-associated disorders.

  本发明涉及具有GPR17调节剂活性的吡啶基和吡嗪基-(氮杂)吲哚磺酰胺。这些化合物在治疗各种与GPR17相关的疾病中具有用途。
• RADIAL SHAPE OF POLYMER COMPOUND CONTAINING IODINE, PREPARATION METHOD THEREOF, AND CT CONTRAST MEDIUM COMPOSITION CONTAINING SAME
  申请人：Korea Research Institute of Bioscience and Biotechnology

  公开号：EP2604289A2

  公开（公告）日：2013-06-19

  Disclosed herein is an iodine-containing radial-shaped macromolecule suitable for an active ingredient of the computed tomography (CT) contrast medium, a method to prepare the same, and a contrast medium composition including the same. With respect to the iodine-containing radial-shaped macromolecule according to the present invention, the duration of contrast enhancement has been significantly improved in comparison to that of the current small molecular contrast media compounds containing iodine, the in vivo toxicity has been reduced by forming a protective layer with relatively long biocompatible polymer chains which prevents the exposure of the toxic iodine-containing compounds substituted near the surface of the core region to the external environment for potential adverse effects, the in vivo circulation time has been increased by preventing rapid uptake by macrophages, the excretion is realized at the adequate time point after the intravascular injection, the large-scale production at high yield and low cost is amenable due to the simple preparation and purification methods, the reproducibility in terms of the preparation and effects is high due to the relatively low polydispersity, and the structural integrity of the iodine-containing radial-shaped macromolecules is firmly ensured because the compound is entirely formed by covalent bonds. Therefore, the iodine-containing radial-shaped macromolecule may be suitable for the preparation of a CT contrast medium.

  本发明公开了一种适用于计算机断层扫描（CT）造影剂活性成分的含碘径向形大分子、其制备方法以及包括其在内的造影剂组合物。与目前的含碘小分子造影剂化合物相比，本发明的含碘径向形大分子造影剂的造影增强持续时间显著提高，通过形成具有相对较长的生物相容性聚合物链的保护层，降低了体内毒性，该保护层可防止核心区域表面附近被取代的有毒含碘化合物暴露于外部环境，从而避免潜在的不利影响、通过防止巨噬细胞的快速吸收，延长了体内循环时间；在血管内注射后的适当时间点实现了排泄；由于制备和纯化方法简单，可实现高产低成本的大规模生产；由于相对较低的多分散性，制备和效果的可重复性较高；由于化合物完全由共价键形成，确保了含碘径向形大分子结构的完整性。因此，该含碘放射状大分子可用于制备 CT 造影剂。
• DEUTERATED OR ISOTOPICALLY LABELED UREA DERIVATIVES OR PHARMACOLOGICALLY ACCEPTABLE SALTS THEREOF USEFUL AS FPRL-1 AGONISTS
  申请人：Kyorin Pharmaceutical Co., Ltd.

  公开号：EP3305763A1

  公开（公告）日：2018-04-11

  Provided is a compound having a formyl peptide receptor like 1 (FPRL1) agonist effect. The present invention relates to a deuterium-substituted or isotopically labeled compound represented by the general formula (I) or a pharmacologically acceptable salt thereof, or a solvate or hydrate thereof. The present invention also relates to a pharmaceutical composition containing the deuterium-substituted or isotopically labeled compound represented by the general formula (I) or a pharmacologically acceptable salt thereof, or a solvate or hydrate thereof.

  本发明提供了一种具有类似甲酰肽受体 1（FPRL1）激动剂作用的化合物。 本发明涉及通式（I）代表的氘代或同位素标记的化合物，或其药理学上可接受的盐，或其溶液或水合物。本发明还涉及一种药物组合物，其中含有通式（I）代表的氘代或同位素标记化合物或其药理学上可接受的盐，或其溶液或水合物。
• Polymeric stabilizing formulations
  申请人：Nano Precision Medical, Inc.

  公开号：US10479868B2

  公开（公告）日：2019-11-19

  The present invention provides compositions of a therapeutic agent and a polymeric stabilizing agent for stabilizing the reservoir of an implantable drug delivery system. The present invention also includes an implantable drug delivery system incorporating the composition of the present invention, as well as methods of treating diabetes using the compositions and implantable drug delivery system of the present invention.

  本发明提供了一种治疗剂和一种聚合物稳定剂的组合物，用于稳定植入式给药系统的储液器。本发明还包括含有本发明组合物的植入式给药系统，以及使用本发明组合物和植入式给药系统治疗糖尿病的方法。