2,3,5,6,7,8-hexahydro-imidazo[1,2-a]pyridine | 27578-58-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 2,3,5,6,7,8-hexahydro-imidazo[1,2-a]pyridine
• 英文别名: 2,3,5,6,7,8-hexahydro-imidazo[1,2-a]pyridine；1,7-Diazabicyclo<4.2.0>nonen-(6)；1,7-Diazabicyclo<4.3.0>non-6-en；2,3,5,6,7,8-Hexahydroimidazo[1,2-a]pyridine
• CAS: 27578-58-1
• 化学式: C₇H₁₂N₂
• 分子量: 124.186
• InChiKey: XRZBJVBMYWGMOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  15.6
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,3,5,6,7,8-hexahydro-imidazo[1,2-a]pyridine 在 二异丁基氢化铝 作用下， 以 甲苯 为溶剂， 反应 3.0h， 以79%的产率得到1,4-diazacyclononane
  参考文献：
  名称：

  Regioselective carbonyl amination using diisobutylaluminum hydride

  摘要：

  DOI：

  10.1021/ja00404a035
• 作为产物：
  描述：

  6-甲氧基-2,3,4,5-四氢吡啶 在 氯化亚砜 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 1.0h， 生成 2,3,5,6,7,8-hexahydro-imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Nonaromatic Amidine Derivatives as Acylation Catalysts

  摘要：

  Catalytic activity of nonaromatic bicyclic amidines and bicyclic isothioureas in acylation reactions was found to be remarkably dependent on the sizes of both rings. DBN and especially its thia-analogue (THTP) have been identified as highly active acylation catalysts.

  DOI：

  10.1021/ol0623419

文献信息

• An efficient three-component synthesis of new amidinium salts
  作者：Somayeh Ahadi、Maryam Abaszadeh、Hamid Reza Khavasi、Ayoob Bazgir

  DOI：10.1007/s13738-013-0251-3

  日期：2013.12

  AbstractA simple and efficient method for the synthesis of new amidinate salts containing barbiturate moiety by a three-component condensation reaction of C–H acids, pyrimidine-tetraone and 1,8-diazabicycloundec-7-ene (DBU) in refluxing CHCl3 without any catalyst is reported. The structures of these compounds were confirmed by IR, MS, 1H-NMR, 13C-NMR, and single-crystal X-ray diffraction studies. Graphical

  摘要一种用于通过的C-H的酸，嘧啶四酮和三组分缩合反应含有巴比妥部分新脒盐合成简单和有效的方法1,8- diazabicycloundec -7-烯（DBU）在回流的氯仿3而没有任何有催化剂报道。这些化合物的结构通过IR，MS，1 H-NMR，13 C-NMR和单晶X射线衍射研究证实。 图形概要 。
• [EN] TRIFLAZOLES AND METHODS OF MAKING THE SAME<br/>[FR] TRIFLAZOLES ET LEURS PROCÉDÉS DE PRODUCTION
  申请人：TRINAPCO INC

  公开号：WO2021154345A1

  公开（公告）日：2021-08-05

  Methods for producing triflazoles or related derivatives thereof, and the resulting products are provided. For example, triflazoles can be prepared by reaction of trifluoromethanesulfonyl fluoride with an azole or azolate salt. Yields up to 78% are obtained. Triflazoles can be prepared by the reaction of a trifluoromethanesulfonyl fluoride with an N-silylazole in the presence of a basic catalyst. Yields up to 97% are obtained.

  提供了制备三氟唑或相关衍生物的方法和所得到的产物。例如，可以通过三氟甲磺酰氟与唑或唑盐反应来制备三氟唑。可以获得高达78%的产量。可以通过在碱性催化剂存在下，将三氟甲磺酰氟与N-硅烷基唑反应来制备三氟唑。可以获得高达97%的产量。
• Process for preparation of spirofluorenols
  申请人：Shiigi Hirohumi

  公开号：US20060025636A1

  公开（公告）日：2006-02-02

  A spirofluorenol such as 3′,9′-dimethoxy-5′-hydroxyspiro[(1H-cyclopent[d,e,f]phenanthrene)-1,7′-benzo [c] fluorene] is produced by protecting a hydroxyl group bonded to a particular fluorenone compound such as 3,9-dimethoxy-5-hydroxybenzo[c]fluorene-7-one with “a substituted silyl group in which the sum of carbon atoms of substituents bonded to a silicon atom is 5 to 12”, such as a t-butyldimethylsilyl group, then, reacting the fluorenone compound with a particular organometal compound such as 1-lithiophenanthrene so as to be transformed into a spiro form and, then, removing the protection therefrom. This method makes it possible to efficiently produce the spirofluorenol which is useful as a starting material for producing photochromic compounds.

  通过保护与特定芴酮化合物（如3,9-二甲氧基-5-羟基苯并[c]芴-7-酮）相连的羟基，使用“取代硅基团，其中硅原子上的取代基的碳原子总数为5至12”，例如t-丁基二甲基硅基团，制备出螺旋芴醇，例如3′，9′-二甲氧基-5′-羟基螺旋[(1H-环戊[d，e，f]菲-1,7′-苯并[c]芴)]。然后，将芴酮化合物与特定的有机金属化合物（如1-锂菲）反应，使其转化为螺旋形式，然后去除保护。该方法可以有效地生产螺旋芴醇，该物质可用作生产光致变色化合物的起始材料。
• Novel triazolopyridazines
  申请人：Calderwood David J.

  公开号：US20090270402A1

  公开（公告）日：2009-10-29

  The present invention is directed to novel compounds of formula (I) wherein the variables are defined as herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.

  本发明涉及式（I）的新化合物，其中变量如此定义。式（I）的化合物可用作激酶抑制剂，在治疗某些情况和疾病方面非常有用，特别是在治疗炎症性疾病和增殖性疾病和情况，例如癌症。
• Method for the Preparation and Use of Bis (Alkoxysilylorgano)-Dicarboxylates
  申请人：Backer Michael

  公开号：US20130072625A1

  公开（公告）日：2013-03-21

  A method for preparing a bis(alkoxysilylorgano)dicarboxylate includes reacting a haloorganoalkoxysilane, a dimetal salt of a dicarboxyl functional compound, and a phase transfer catalyst. A quaternary iminium compound of a polyaza, polycycloalkene is useful as the phase transfer catalyst. The product may be a bis(alkoxysilylalkyl)fumarate, which is useful as a coupling agent in rubber compositions for tire applications.

  一种制备双（烷氧基硅烷基）二羧酸酯的方法包括反应卤代有机烷氧基硅烷、二羧酸官能化合物的二金属盐和相转移催化剂。一种多氮杂环烷化合物的季铵化合物可用作相转移催化剂。产物可能是双（烷氧基硅烷基）丁烯二酸酯，它可用作轮胎应用的橡胶组合物的偶联剂。