4-methylsulfonylbenzoyl azide | 35674-93-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methylsulfonylbenzoyl azide
• 英文别名: p-Methylsulfonylbenzoylazid；4-methanesulfonyl-benzoyl azide；4-Methansulfonyl-benzoylazid
• CAS: 35674-93-2
• 化学式: C₈H₇N₃O₃S
• 分子量: 225.228
• InChiKey: SUVYFJLRUJNSRK-UHFFFAOYSA-N

物化性质

• 熔点：
  130 °C (decomp)(Solvent: Ethanol)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  74
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-methylsulfonylbenzoyl azide 生成 1-异氰酸基-4-(甲磺酰基)苯
  参考文献：
  名称：

  Monosized macroporous resins with epoxy groups and their structure and gel chromatography properties

  摘要：

  The monosized macroporous-polymer beads based on cross-linked poly(glycidyl methacrylate) have been synthesized by a new improving method-combining dispersion polymerization with swelling polymerization and polymeric solution porogens. The structure and gel chromatographic properties of the resins have been studied. The resins as matrix materials of various types of high performance liquid chromatography (HPLC) packings possess excellent separation properties.

  DOI：

  10.1007/bf02884676
• 作为产物：
  描述：

  α,α-dibromo-4-methanesulfonylacetophenone 在 sodium azide 作用下， 以 水 、 丙酮 为溶剂， 以91%的产率得到4-methylsulfonylbenzoyl azide
  参考文献：
  名称：

  Abbau von Aryl-methyl-ketonen zu Aroyl-aziden

  摘要：

  DOI：

  10.1055/s-1983-30274

文献信息

• Synthesis of Acyl Phosphoramidates Employing a Modified Staudinger Reaction
  作者：Iain Currie、Brad E. Sleebs

  DOI：10.1021/acs.orglett.0c03987

  日期：2021.1.15

  A one-step synthesis of acyl phosphoramidates from a variety of functionalized acyl azides has been developed employing trimethylsilyl chloride as an activating agent in a modified Staudinger reaction. The methodology was further adapted to include the in situ generation of the acyl azides from a diverse selection of carboxylic acids and hydrazide starting synthons. The reaction scope was extended

  在改良的施陶丁格反应中，采用三甲基甲硅烷基氯作为活化剂，已经开发了由多种官能化的酰基叠氮化物一步合成酰基氨基磷酸酯的方法。该方法进一步适于包括从多种选择的羧酸和酰肼起始合成子中原位产生酰基叠氮化物。反应范围扩大到包括亚氨基二磷酸酯和天然产物Microcin C的合成。
• MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
  申请人：Melinta Therapeutics, Inc.

  公开号：US20150158901A1

  公开（公告）日：2015-06-11

  The present invention provides macrocyclic compounds useful as therapeutic agents of the formula: or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug thereof, wherein T, R 1 , R 2 , R 3 , D, E, F, and G are as defined herein. More particularly, these compounds are useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents.

  本发明提供了用作治疗剂的大环化合物，其化学式为：其中T，R1，R2，R3，D，E，F和G的定义如本文所述，或其药学上可接受的盐，酯，N-氧化物或前药。更具体地说，这些化合物可用作抗感染，抗增殖，抗炎和促动力剂。
• WEBER, G.;HAUPTMANN, S.;WILDE, H.;MANN, G., SYNTHESIS, 1983, N 3, 191-192
  作者：WEBER, G.、HAUPTMANN, S.、WILDE, H.、MANN, G.

  DOI：——

  日期：——
• Abbau von Aryl-methyl-ketonen zu Aroyl-aziden
  作者：Gunther Weber、Siegfried Hauptmann、Horst Wilde、Gerhard Mann

  DOI：10.1055/s-1983-30274

  日期：——
• Monosized macroporous resins with epoxy groups and their structure and gel chromatography properties
  作者：Chao Jin、Yanguo Yang、Zhongzhang Zhao、Shuming Yang、Xiulan Tian、Tiansheng Su

  DOI：10.1007/bf02884676

  日期：2000.2

  The monosized macroporous-polymer beads based on cross-linked poly(glycidyl methacrylate) have been synthesized by a new improving method-combining dispersion polymerization with swelling polymerization and polymeric solution porogens. The structure and gel chromatographic properties of the resins have been studied. The resins as matrix materials of various types of high performance liquid chromatography (HPLC) packings possess excellent separation properties.