2-氨基-1,6-二甲基咪唑并[4,5-b]吡啶 | 132898-04-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 中文名称: 2-氨基-1,6-二甲基咪唑并[4,5-b]吡啶
• 中文别名: 2-氨基-1,6-二甲基咪唑并吡啶
• 英文名称: 2-amino-1-methyl-6-phenylimidazo<4,5-b>pyridine
• 英文别名: 2-Amino-1,6-dimethylimidazo<4,5-b>pyridine；2-amino-1,5-dimethylimidazo<4,5-b>pyridine；2-amino-1,6-dimethylimidazo[4,5-b]pyridine；DMIP；1,6-dimethylimidazo[4,5-b]pyridin-2-amine
• CAS: 132898-04-5
• 化学式: C₈H₁₀N₄
• mdl: MFCD00269879
• 分子量: 162.194
• InChiKey: NEOGGGHDLGYATP-UHFFFAOYSA-N

物化性质

• 熔点：
  265-270°C dec.
• 沸点：
  366.4±34.0 °C(Predicted)
• 密度：
  1.35±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  56.7
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  N3,5-二甲基-2,3-吡啶二胺 在 ammonium hydroxide 、 五氯化磷 、 三氯氧磷 作用下， 反应 6.0h， 生成 2-氨基-1,6-二甲基咪唑并[4,5-b]吡啶
  参考文献：
  名称：

  Lindstroem, Stefan; Ahmad, Tania; Grivas, Spiros, Heterocycles, 1994, vol. 38, # 3, p. 529 - 540

  摘要：

  DOI：

文献信息

• Cross-Coupling Reaction of 2-halo1-methyl-1H-imidazo[4,5-b]pyridine Offers a New Synthetic Route to Mutagenic Heterocyclic Amine-PHIP and DMIP
  作者：Ayyiliath M. Sajith、Arayambath Muralidharan、Ranjith P. Karuvalam、Karickal R. Haridas

  DOI：10.5012/jkcs.2013.57.3.361

  日期：2013.6.20

  A modified synthetic approach to the synthesis of heterocyclic food mutagens, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PHIP) and 2-amino-1,6-dimethylimidazo[4,5-b]pyridine (DMIP) is reported. This route highlights an optimized palladium catalysed Buchwald cross-coupling of 2-halo-1-methyl-imidazo[4,5-b]pyridine with benzophenoneimine followed by acidic hydrolysis to yield compound 7. Using finely tailored conditions, Suzuki cross-coupling reactions with highly efficient catalytic systems were performed as the final step on 8 to introduce the aryl group and methyl group on the heterocyclic core.

  杂环食品诱变剂 2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶 (PHIP) 和 2-氨基-1,6-二甲基咪唑[4,5-b] 的改进合成方法] 吡啶 (DMIP) 已被报道。该路线重点介绍了 2-卤代-1-甲基-咪唑并[4,5-b]吡啶与二苯甲酮亚胺的优化钯催化 Buchwald 交叉偶联，然后进行酸水解，生成化合物 7。使用精心设计的条件，Suzuki 交叉偶联反应作为8的最后一步，使用高效催化系统在杂环核上引入芳基和甲基。
• System and method for extracting a target moiety from a sample using acoustic droplet ejection
  申请人：Labcyte Inc.

  公开号：US10871430B2

  公开（公告）日：2020-12-22

  A method and system are provided for extracting a target analyte from a sample using acoustic ejection technology. The method involves applying focused acoustic energy to a fluid reservoir housing a fluid composition that contains a target analyte and comprises an upper region and a lower region, where the concentration of the target analyte in the upper region differs from that in the lower region. The focused acoustic energy is applied in a manner that is effective to result in the ejection of a fluid droplet from from the fluid composition into a droplet receiver, wherein the concentration of the analyte in the droplet corresponds to either the concentration of the analyte in the upper region or the concentration of the analyte in the lower region, and wherein the concentration of the analyte is substantially uniform throughout the droplet. The fluid composition may comprise an ionic liquid, used in the extraction of ionic target analytes. Related methods and an acoustic extraction system are also provided.

  本文提供了一种利用声学喷射技术从样品中提取目标分析物的方法和系统。该方法包括将聚焦声波能量应用于一个流体储液器，该储液器容纳含有目标分析物的流体组合物，并包括一个上部区域和一个下部区域，其中上部区域的目标分析物浓度与下部区域的目标分析物浓度不同。聚焦声能的应用方式能有效地将流体液滴从流体组合物中喷射到液滴接收器中，其中液滴中分析物的浓度与上部区域中分析物的浓度或下部区域中分析物的浓度相对应，并且分析物的浓度在整个液滴中基本均匀。流体成分可包括离子液体，用于离子目标分析物的萃取。还提供了相关方法和声学萃取系统。
• Synthesis of mutagenic heterocyclic amines PhIP and DMIP
  作者：Tominari Choshi、Akiko Tonari、Haruyuki Yoshioka、Kenichi Harada、Eiichi Sugino、Satoshi Hibino

  DOI：10.1021/jo00079a055

  日期：1993.12
• Lindstroem Stefan, Ahmad Tania, Grivas Spiros, Heterocycles, 38 (1994) N 3, S 529-540
  作者：Lindstroem Stefan, Ahmad Tania, Grivas Spiros

  DOI：——

  日期：——
• SYSTEM AND METHOD FOR EXTRACTING A TARGET MOIETY FROM A SAMPLE USING ACOUSTIC DROPLET EJECTION
  申请人：Labcyte Inc.

  公开号：US20190301986A1

  公开（公告）日：2019-10-03

  A method and system are provided for extracting a target analyte from a sample using acoustic ejection technology. The method involves applying focused acoustic energy to a fluid reservoir housing a fluid composition that contains a target analyte and comprises an upper region and a lower region, where the concentration of the target analyte in the upper region differs from that in the lower region. The focused acoustic energy is applied in a manner that is effective to result in the ejection of a fluid droplet from from the fluid composition into a droplet receiver, wherein the concentration of the analyte in the droplet corresponds to either the concentration of the analyte in the upper region or the concentration of the analyte in the lower region, and wherein the concentration of the analyte is substantially uniform throughout the droplet. The fluid composition may comprise an ionic liquid, used in the extraction of ionic target analytes. Related methods and an acoustic extraction system are also provided.