3-(4-tert-butylphenyl)-2-phenylpropan-1-ol | 198641-81-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 3-(4-tert-butylphenyl)-2-phenylpropan-1-ol
• CAS: 198641-81-5
• 化学式: C₁₉H₂₄O
• 分子量: 268.399
• InChiKey: CQMFQKDLOZIZBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(4-tert-butylphenyl)-2-phenylpropan-1-ol 在 palladium on activated charcoal 三异丙氧基氯化钛 、 N-溴代丁二酰亚胺(NBS) 、 正丁基锂 、 氢气 、 二异丁基氢化铝 、 三苯基膦 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 甲苯 为溶剂， 生成
  参考文献：
  名称：

  Design and synthesis of novel 2,7-dialkyl substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides as in vitro potent peptidomimetic inhibitors of human renin

  摘要：

  Novel low-molecular weight transition-state peptidomimetic renin inhibitors characterized by an all-carbon X-phenyl substituted octanecarboxamide skeleton have been discovered based on a topographical design approach. The in vitro most potent inhibitors 21, 25 and 26 incorporating a strong H-bond acceptor group linked to the benzyl spacer of the (P-3-P-1)-unit had IC(50)s in the low nanomolar range against human renin. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10067-1
• 作为产物：
  描述：

  4-叔丁基甲苯 在 N-溴代丁二酰亚胺(NBS) 、 lithium aluminium tetrahydride 、 正丁基锂 、 苄硫醇 、 lithium hexamethyldisilazane 作用下， 以 四氯化碳 为溶剂， 生成 3-(4-tert-butylphenyl)-2-phenylpropan-1-ol
  参考文献：
  名称：

  Design and synthesis of novel 2,7-dialkyl substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides as in vitro potent peptidomimetic inhibitors of human renin

  摘要：

  Novel low-molecular weight transition-state peptidomimetic renin inhibitors characterized by an all-carbon X-phenyl substituted octanecarboxamide skeleton have been discovered based on a topographical design approach. The in vitro most potent inhibitors 21, 25 and 26 incorporating a strong H-bond acceptor group linked to the benzyl spacer of the (P-3-P-1)-unit had IC(50)s in the low nanomolar range against human renin. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)10067-1

文献信息

• First practical cross-alkylation of primary alcohols with a new and recyclable impregnated iridium on magnetite catalyst
  作者：Rafael Cano、Miguel Yus、Diego J. Ramón

  DOI：10.1039/c2cc33101b

  日期：——

  A new impregnated iridium on magnetite catalyst has been prepared, characterized, used and recycled, up to ten times with practically the same activity, for the first practical cross-alkylation of primary alcohols. The catalyst showed a wide reaction scope, is easy to prepare and handle, and it could be removed from the reaction medium just by magnetic sequestering.

  一种新的磁铁矿负载铱催化剂已被制备、表征、使用并循环利用，最多可循环十次，活性几乎保持不变，用于首例实际的伯醇交叉烷基化反应。该催化剂显示了广泛的反应范围，易于制备和操作，并且可以通过磁性捕集从反应介质中轻松移除。
• Cross β-arylmethylation of alcohols catalysed by recyclable Ti–Pd alloys not requiring pre-activation
  作者：Masayoshi Utsunomiya、Ryota Kondo、Toshinori Oshima、Masatoshi Safumi、Takeyuki Suzuki、Yasushi Obora

  DOI：10.1039/d1cc01388b

  日期：——

  Recyclable and pre-activation free Ti–Pd alloy catalysts promote cross β-alkylation of primary alcohols via hydrogen autotransfer.

  可回收且无需预激活的Ti-Pd合金催化剂促进了一次醇的交叉β-烷基化，通过氢自转移。
• Design and synthesis of novel 2,7-dialkyl substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides as in vitro potent peptidomimetic inhibitors of human renin
  作者：Richard Göschke、Nissim Claude Cohen、Jeanette M. Wood、Jürgen Maibaum

  DOI：10.1016/s0960-894x(97)10067-1

  日期：1997.11

  Novel low-molecular weight transition-state peptidomimetic renin inhibitors characterized by an all-carbon X-phenyl substituted octanecarboxamide skeleton have been discovered based on a topographical design approach. The in vitro most potent inhibitors 21, 25 and 26 incorporating a strong H-bond acceptor group linked to the benzyl spacer of the (P-3-P-1)-unit had IC(50)s in the low nanomolar range against human renin. (C) 1997 Elsevier Science Ltd.