(2,3-Dihydroxyphenyl)(3,4,5-trihydroxyphenyl)methanone | 114415-01-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2,3-Dihydroxyphenyl)(3,4,5-trihydroxyphenyl)methanone
• 英文别名: (2,3-dihydroxyphenyl)-(3,4,5-trihydroxyphenyl)methanone
• CAS: 114415-01-9
• 化学式: C₁₃H₁₀O₆
• 分子量: 262.21
• InChiKey: LMZNOSFQBKBMNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  118
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  没食子酸 、 邻苯二酚 生成 (2,3-Dihydroxyphenyl)(3,4,5-trihydroxyphenyl)methanone
  参考文献：
  名称：

  TAKATORI, MASASIGEH;NODZUEH, IKUO;XARUDA, JOSIYUKI

  摘要：

  DOI：

文献信息

• [EN] COMPOSITIONS OF POLYHYDROXYLATED BENZOPHENONES AND METHODS OF TREATMENT OF NEURODEGENERATIVE DISORDERS<br/>[FR] COMPOSITIONS DE BENZOPHÉNONES POLYHYDROXYLÉS ET MÉTHODES DE TRAITEMENT DE TROUBLES NEURODÉGÉNÉRATIFS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2017106861A1

  公开（公告）日：2017-06-22

  The present invention relates to polyhydroxylated benzophenone compounds useful in the treatment of neurodegenerative, neurological, psychiatric, and cognitive diseases, in particular those associated with a deficiency in HDAC1 deacetylase activity.

  本发明涉及聚羟基苯酮类化合物，其在治疗神经退行性、神经学、精神病和认知疾病中有用，特别是那些与HDAC1脱乙酰化酶活性缺乏有关的疾病。
• Compositions of polyhydroxylated benzophenones and methods of treatment of neurodegenerative disorders
  申请人：Massachusetts Institute of Technology

  公开号：US11180438B2

  公开（公告）日：2021-11-23

  The present invention relates to polyhydroxylated benzophenone compounds useful in the treatment of neurodegenerative, neurological, psychiatric, and cognitive diseases, in particular those associated with a deficiency in HDAC1 deacetylase activity.

  本发明涉及多羟基二苯甲酮化合物，可用于治疗神经退行性疾病、神经疾病、精神疾病和认知疾病，特别是与 HDAC1 去乙酰化酶活性缺乏有关的疾病。
• TAKATORI, MASASIGEH;NODZUEH, IKUO;XARUDA, JOSIYUKI
  作者：TAKATORI, MASASIGEH、NODZUEH, IKUO、XARUDA, JOSIYUKI

  DOI：——

  日期：——
• JPS62298548A
  申请人：——

  公开号：JPS62298548A

  公开（公告）日：1987-12-25
• COMPOSITIONS OF POLYHYDROXYLATED BENZOPHENONES AND METHODS OF TREATMENT OF NEURODEGENERATIVE DISORDERS
  申请人：Massachusetts Institute of Technology

  公开号：US20200087236A9

  公开（公告）日：2020-03-19

  The present invention relates to polyhydroxylated benzophenone compounds useful in the treatment of neurodegenerative, neurological, psychiatric, and cognitive diseases, in particular those associated with a deficiency in HDAC1 deacetylase activity.