2-氨基-3-溴苯硫酚 | 73628-28-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯硫酚类
• 中文名称: 2-氨基-3-溴苯硫酚
• 英文名称: 2-Amino-3-bromothiophenol
• 英文别名: 2-amino-3-bromobenzenethiol
• CAS: 73628-28-1
• 化学式: C₆H₆BrNS
• 分子量: 204.09
• InChiKey: QAKGZDFJIHWLST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  27
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• COMPOUND FOR SPECIFICALLY BINDING TO AMYLOID ß-PROTEIN
  申请人：Neuboron Medtech Ltd.

  公开号：US20180298037A1

  公开（公告）日：2018-10-18

  Provided is a compound for specifically binding to amyloid β-protein. The compound has thereon a nuclide with a large thermal neutron capture cross section and the compound is capable of specifically binding to the amyloid β-protein. The property of the compound allows it to be used in conjunction with a neutron capture therapy device to eliminate amyloid β-protein. Similarly, when the compound is labelled with radioactive element 11 C, the compound can also be used in conjunction with PET/CT for determining the part of the brain where amyloid β-protein is deposited, for diagnosing Alzheimer's disease. Also disclosed is a preparation process for the compound. The beneficial effect of the present disclosure is to make the therapy and diagnosis of Alzheimer's disease more targeted by providing the compound for specifically binding to amyloid β-protein.

  提供的是一种专门结合淀粉样蛋白β的化合物。该化合物上有一个具有大热中子俘获截面的核素，并且该化合物能够专门结合淀粉样蛋白β。该化合物的性质使其能够与中子俘获疗法设备结合使用，以消除淀粉样蛋白β。类似地，当该化合物标记有放射性元素 11 C时，该化合物也可以与PET/CT结合使用，用于确定淀粉样蛋白β沉积在大脑的哪个部位，用于诊断阿尔茨海默病。还公开了该化合物的制备过程。本公开的有益效果是通过提供专门结合淀粉样蛋白β的化合物，使阿尔茨海默病的治疗和诊断更具有针对性。
• [EN] MOLECULAR AND POLYMERIC SEMICONDUCTORS AND RELATED DEVICES<br/>[FR] SEMI-CONDUCTEURS POLYMÈRES ET MOLÉCULAIRES ET DISPOSITIFS ASSOCIÉS
  申请人：POLYERA CORP

  公开号：WO2016025632A1

  公开（公告）日：2016-02-18

  The present invention relates to new semiconducting compounds having at least one optionally substituted benzo[d][1,2,3]thiadiazole moiety. The compounds disclosed herein can exhibit high carrier mobility and/or efficient light absorption/emission characteristics, and can possess certain processing advantages such as solution-processability and/or good stability at ambient conditions.

  本发明涉及具有至少一个可选择取代的苯并[d][1,2,3]噻二唑基团的新半导体化合物。本文披露的化合物可以表现出高载流子迁移率和/或有效的光吸收/发射特性，并且可以具有某些加工优势，如可溶性加工性能和/或在常温下良好的稳定性。
• NEUTRON CAPTURE THERAPY SYSTEM FOR ELIMINATING AMYLOID ß-PROTEIN
  申请人：Neuboron Medtech Ltd.

  公开号：EP3384960A1

  公开（公告）日：2018-10-10

  A neutron capture therapy system capable of eliminating amyloid β-protein includes a neutron capture therapy device and a compound capable of specifically binding to the amyloid β-protein having a nuclide with a large thermal neutron capture cross section. The neutron capture therapy device includes a neutron source, a beam shaping assembly and a collimator, the neutrons released by the neutron source pass through the beam shaping assembly and are slowed into a neutron beam within a certain energy range. The neutron beam irradiates the compound, and the energy generated by the reaction thereof can destroy the structure of the amyloid β-protein. The neutron capture therapy system can specifically eliminate the amyloid β-protein, and reduce the damage to the tissues surrounding the amyloid β-protein.

  一种能够消除淀粉样β蛋白的中子俘获治疗系统包括一个中子俘获治疗装置和一种能够与淀粉样β蛋白特异性结合的化合物，该化合物具有一个大热中子俘获截面的核素。中子俘获治疗装置包括一个中子源、一个光束整形组件和一个准直器，中子源释放的中子通过光束整形组件并被减速成一定能量范围内的中子束。中子束照射化合物，其反应产生的能量可破坏淀粉样β蛋白的结构。中子俘获治疗系统可以特异性地消除淀粉样 β 蛋白，并减少对淀粉样 β 蛋白周围组织的损伤。
• COMPOUND FOR SPECIFIC BINDING WITH AMYLOID PROTEIN
  申请人：Neuboron Medtech Ltd.

  公开号：EP3385266A1

  公开（公告）日：2018-10-10

  Provided is a compound for specifically binding to amyloid β-protein. The compound has thereon a nuclide with a large thermal neutron capture cross section and the compound is capable of specifically binding to the amyloid β-protein. The property of the compound allows it to be used in conjunction with a neutron capture therapy device to eliminate amyloid β-protein. Similarly, when the compound is labelled with radioactive element 11C, the compound can also be used in conjunction with PET/CT for determining the part of the brain where amyloid β-protein is deposited, for diagnosing Alzheimer's disease. Also disclosed is a preparation process for the compound. The beneficial effect of the present disclosure is to make the therapy and diagnosis of Alzheimer's disease more targeted by providing the compound for specifically binding to amyloid β-protein.

  本研究提供了一种能与淀粉样β蛋白特异性结合的化合物。该化合物中含有一种具有较大热中子俘获截面的核素，该化合物能够与淀粉样β蛋白特异性结合。该化合物的这一特性使其能够与中子俘获治疗装置结合使用，以消除淀粉样 β 蛋白。同样，当该化合物用放射性元素 11C 标记时，还可与 PET/CT 结合使用，以确定淀粉样 β 蛋白沉积在大脑的哪个部位，从而诊断阿尔茨海默氏症。本发明还公开了一种化合物的制备工艺。本公开的有益效果是通过提供与淀粉样β蛋白特异性结合的化合物，使阿尔茨海默病的治疗和诊断更具针对性。
• Compound for specifically binding to amyloid β-protein
  申请人：NEUBORON MEDTECH LTD.

  公开号：US10239895B2

  公开（公告）日：2019-03-26

  Provided is a compound for specifically binding to amyloid β-protein. The compound has thereon a nuclide with a large thermal neutron capture cross section and the compound is capable of specifically binding to the amyloid β-protein. The property of the compound allows it to be used in conjunction with a neutron capture therapy device to eliminate amyloid β-protein. Similarly, when the compound is labelled with radioactive element 11C, the compound can also be used in conjunction with PET/CT for determining the part of the brain where amyloid β-protein is deposited, for diagnosing Alzheimer's disease. Also disclosed is a preparation process for the compound. The beneficial effect of the present disclosure is to make the therapy and diagnosis of Alzheimer's disease more targeted by providing the compound for specifically binding to amyloid β-protein.

  本研究提供了一种能与淀粉样β蛋白特异性结合的化合物。该化合物中含有一种具有较大热中子俘获截面的核素，该化合物能够与淀粉样β蛋白特异性结合。该化合物的这一特性使其能够与中子俘获治疗装置结合使用，以消除淀粉样 β 蛋白。同样，当该化合物用放射性元素 11C 标记时，还可与 PET/CT 结合使用，以确定淀粉样 β 蛋白沉积在大脑的哪个部位，从而诊断阿尔茨海默氏症。本发明还公开了一种化合物的制备工艺。本公开的有益效果是通过提供与淀粉样β蛋白特异性结合的化合物，使阿尔茨海默病的治疗和诊断更具针对性。