(2R)-1-bromo-3-phenylmethoxypropan-2-ol | 1269986-80-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R)-1-bromo-3-phenylmethoxypropan-2-ol
• CAS: 1269986-80-2
• 化学式: C₁₀H₁₃BrO₂
• 分子量: 245.116
• InChiKey: VWASIEISPISOIQ-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (S)-苄氧甲基环氧乙烷 在 乙烯基溴化镁 作用下， 以 四氢呋喃 为溶剂， 生成 (2R)-1-bromo-3-phenylmethoxypropan-2-ol
  参考文献：
  名称：

  Development of a Robust Procedure for the Copper-catalyzed Ring-Opening of Epoxides with Grignard Reagents

  摘要：

  A general procedure for the copper-catalyzed regioselective ring-opening of epoxides with Grignard reagents is described. The procedure developed provides robust reaction conditions which limit the formation of impurities and has been applied successfully using a series of epoxides and Grignard reagents to provide the desired products in >90% yield with excellent regioselectivity and purity.

  DOI：

  10.1021/op200329x

文献信息

• Development of a Robust Procedure for the Copper-catalyzed Ring-Opening of Epoxides with Grignard Reagents
  作者：Mahbub Alam、Christopher Wise、Carl A. Baxter、Ed Cleator、Andrew Walkinshaw

  DOI：10.1021/op200329x

  日期：2012.3.16

  A general procedure for the copper-catalyzed regioselective ring-opening of epoxides with Grignard reagents is described. The procedure developed provides robust reaction conditions which limit the formation of impurities and has been applied successfully using a series of epoxides and Grignard reagents to provide the desired products in >90% yield with excellent regioselectivity and purity.