(S)-2-(4-bromophenyl)-2-hydroxyacetamide | 144664-12-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-2-(4-bromophenyl)-2-hydroxyacetamide
• 英文别名: (2S)-2-(4-bromophenyl)-2-hydroxyacetamide
• CAS: 144664-12-0
• 化学式: C₈H₈BrNO₂
• 分子量: 230.061
• InChiKey: SDCWNZRNYDRILA-ZETCQYMHSA-N

物化性质

• 沸点：
  419.7±40.0 °C(Predicted)
• 密度：
  1.673±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(4-溴苯基)-2-氧代乙酸 在 a-无水葡萄糖酯 、 Candida parapsilosis ATCC 7330 、 氨 、 乙酰氯 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 12.0h， 生成 (R)-2-(4-bromophenyl)-2-hydroxyacetamide 、 (S)-2-(4-bromophenyl)-2-hydroxyacetamide
  参考文献：
  名称：

  Biocatalytic reduction of α-keto amides to (R)-α-hydroxy amides using Candida parapsilosis ATCC 7330

  摘要：

  Biocatalytic reduction of primary and secondary alpha-keto amides was accomplished using whole cells of Candida parapsilosis ATCC 7330. The primary (R)-alpha-hydroxy amides were obtained in good enantiomeric excess (up to 94%) and conversion (88-99%) as compared to the secondary (R)-alpha-hydroxy amides. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.cattod.2012.03.081

文献信息

• Biocatalytic reduction of α-keto amides to (R)-α-hydroxy amides using Candida parapsilosis ATCC 7330
  作者：Selvaraj Stella、Anju Chadha

  DOI：10.1016/j.cattod.2012.03.081

  日期：2012.12

  Biocatalytic reduction of primary and secondary alpha-keto amides was accomplished using whole cells of Candida parapsilosis ATCC 7330. The primary (R)-alpha-hydroxy amides were obtained in good enantiomeric excess (up to 94%) and conversion (88-99%) as compared to the secondary (R)-alpha-hydroxy amides. (C) 2012 Elsevier B.V. All rights reserved.