2-[3,3-Bis[diethoxy(oxido)phosphaniumyl]propyl]-1,3-dioxolane | 926026-49-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: 2-[3,3-Bis[diethoxy(oxido)phosphaniumyl]propyl]-1,3-dioxolane
• 英文别名: 2-[3,3-bis[diethoxy(oxido)phosphaniumyl]propyl]-1,3-dioxolane
• CAS: 926026-49-5
• 化学式: C₁₄H₃₀O₈P₂
• 分子量: 388.335
• InChiKey: LYPNPDKCRKTZBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  24
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  102
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2-[3,3-Bis[diethoxy(oxido)phosphaniumyl]propyl]-1,3-dioxolane 在 溶剂黄146 作用下， 以 水 为溶剂， 反应 4.0h， 以73%的产率得到tetraethyl 4-oxobutylene-1,1-bisphosphonate
  参考文献：
  名称：

  Synthesis of novel phosphonated tripodal ligands for actinides chelation therapy

  摘要：

  Efficient synthetic routes for preparation of a new family of aldehyde-bisphosphonate conjugates were presented. These compounds appeared as promising intermediates for incorporation of bisphosphonate moiety in various substrates under mild conditions. We report here a first application to the synthesis of a series of three phosphonated tripods designed for actinides chelation therapy. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.11.094
• 作为产物：
  描述：

  2-(2-溴乙基)-1,3-二恶烷 、 亚甲基二磷酸四乙酯 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 49.0h， 以69%的产率得到2-[3,3-Bis[diethoxy(oxido)phosphaniumyl]propyl]-1,3-dioxolane
  参考文献：
  名称：

  Synthesis of novel phosphonated tripodal ligands for actinides chelation therapy

  摘要：

  Efficient synthetic routes for preparation of a new family of aldehyde-bisphosphonate conjugates were presented. These compounds appeared as promising intermediates for incorporation of bisphosphonate moiety in various substrates under mild conditions. We report here a first application to the synthesis of a series of three phosphonated tripods designed for actinides chelation therapy. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.11.094

文献信息

• Synthesis of novel phosphonated tripodal ligands for actinides chelation therapy
  作者：Vincent Chaleix、Marc Lecouvey

  DOI：10.1016/j.tetlet.2006.11.094

  日期：2007.1

  Efficient synthetic routes for preparation of a new family of aldehyde-bisphosphonate conjugates were presented. These compounds appeared as promising intermediates for incorporation of bisphosphonate moiety in various substrates under mild conditions. We report here a first application to the synthesis of a series of three phosphonated tripods designed for actinides chelation therapy. (c) 2006 Elsevier Ltd. All rights reserved.