2,3,5,6-tetra(furan-2-yl)pyrazine | 4989-05-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,3,5,6-tetra(furan-2-yl)pyrazine
• 英文别名: 2,3,5,6-tetra-2-furylpyrazine；tetra-furan-2-yl-pyrazine；2,3,5,6-Tetrakis(2-furyl)pyrazine；2,3,5,6-Tetrakis--pyrazin；Tetra<2>furyl-pyrazin；2,3,5,6-Tetrakis(furan-2-yl)pyrazine
• CAS: 4989-05-3
• 化学式: C₂₀H₁₂N₂O₄
• 分子量: 344.326
• InChiKey: SMCCOZVCDNTTQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,2'-联糠醛 在 ammonium acetate 作用下， 反应 0.83h， 以89%的产率得到2,3,5,6-tetra(furan-2-yl)pyrazine
  参考文献：
  名称：

  在无催化剂和无溶剂条件下改进的多取代吡嗪的合成

  摘要：

  摘要 已经开发出了各种2-羟基-1，2-二芳基酮衍生物与乙酸铵或胺之间的一锅法假四组分反应，可以在无催化剂和无溶剂条件下合成取代的吡嗪。该方法提供了一种在绿色条件下以优异的产率获得吡嗪衍生物的合成方法。 已经开发出了各种2-羟基-1，2-二芳基酮衍生物与乙酸铵或胺之间的一锅法假四组分反应，可以在无催化剂和无溶剂条件下合成取代的吡嗪。该方法提供了一种在绿色条件下以优异的产率获得吡嗪衍生物的合成方法。

  DOI：

  10.1055/s-0035-1562789

文献信息

• Methods for treating leukemia and myelodysplastic syndrome, and methods for identifying agents for treating same
  申请人：Mustelin Tomas

  公开号：US20090105240A1

  公开（公告）日：2009-04-23

  The present disclosure relates to methods for treating leukemia, pre-leukemic conditions, as well as myelodysplastic syndrome and acute myelogenous leukemia. The present disclosure further relates to compounds that can be used for treating leukemia, pre-leukemic conditions, as well as myelodysplastic syndrome and acute myelogenous leukemia. The present disclosure also relates to methods for identifying compounds that can be used for treating leukemia, pre-leukemic conditions, as well as myelodysplastic syndrome.

  本公开涉及治疗白血病、白血病前期病症、以及骨髓增生异常综合征和急性髓系白血病的方法。本公开还涉及可用于治疗白血病、白血病前期病症、以及骨髓增生异常综合征和急性髓系白血病的化合物。本公开还涉及用于识别可用于治疗白血病、白血病前期病症、以及骨髓增生异常综合征的化合物的方法。
• Phosphine Supported Ruthenium Nanoparticle Catalyzed Synthesis of Substituted Pyrazines and Imidazoles from α-Diketones
  作者：Prasad Ganji、Piet W. N. M. van Leeuwen

  DOI：10.1021/acs.joc.6b03032

  日期：2017.2.3

  pyrazines and imidazoles starting from α-diketones using phosphine supported ruthenium nanoparticles (RuNPs) as catalysts. Ruthenium nanoparticles Ru1–Ru4 supported with different phosphines such as dbdocphos, dppp, DPEphos, and Xantphos are screened, of which Ru1 and Ru4 are found to be the most active. Interestingly, aryl-substituted and alkyl-substituted α-diketones produced different products: namely

  已经开发出一种新的方法，以膦为载体的钌纳米颗粒（RuNPs）作为催化剂，从α-二酮开始合成高度取代的氮杂环，例如吡嗪和咪唑。筛选了负载有不同膦（如dbdocphos，dppp，DPEphos和Xantphos）的钌纳米颗粒Ru1 - Ru4，其中Ru1和Ru4具有最强的活性。有趣的是，芳基取代的α-二酮和烷基取代的α-二酮分别产生不同的产物：即吡嗪和咪唑。该反应方法已应用于关键中间体（2m）的海洋细胞毒性天然产物Dragmacidin B和雌激素受体（2l）。这项工作代表了RuNPs制备的吡嗪的第一个实例。
• Wiemann,J. et al., Bulletin de la Societe Chimique de France, 1965, p. 3476 - 3478
  作者：Wiemann,J. et al.

  DOI：——

  日期：——
• METHODS FOR TREATING LEUKEMIA AND MYELODYSPLASTIC SYNDROME, AND METHODS FOR IDENTIFYING AGENTS FOR TREATING SAME
  申请人：Mustelin Tomas

  公开号：US20120095032A1

  公开（公告）日：2012-04-19

  The present disclosure relates to methods for treating leukemia, pre-leukemic conditions, as well as myelodysplastic syndrome and acute myelogenous leukemia. The present disclosure further relates to compounds that can be used for treating leukemia, pre-leukemic conditions, as well as myelodysplastic syndrome and acute myelogenous leukemia. The present disclosure also relates to methods for identifying compounds that can be used for treating leukemia, pre-leukemic conditions, as well as myelodysplastic syndrome.
• An Improved Synthesis of Multi-Substituted Pyrazines under Catalyst- and Solvent-Free Conditions
  作者：Fatemeh Tamaddon、Arefeh Tafti、Farzaneh Pooramini

  DOI：10.1055/s-0035-1562789

  日期：——

  and solvent-free conditions. This procedure provides a synthetic method to access pyrazine derivatives in excellent yields under green conditions. A one-pot pseudo four-component reaction between a variety of 2-hydroxy-1,2-diarylethanone derivatives and ammonium acetate or amines has been developed to synthesize substituted pyrazines under catalyst-free and solvent-free conditions. This procedure provides

  摘要 已经开发出了各种2-羟基-1，2-二芳基酮衍生物与乙酸铵或胺之间的一锅法假四组分反应，可以在无催化剂和无溶剂条件下合成取代的吡嗪。该方法提供了一种在绿色条件下以优异的产率获得吡嗪衍生物的合成方法。 已经开发出了各种2-羟基-1，2-二芳基酮衍生物与乙酸铵或胺之间的一锅法假四组分反应，可以在无催化剂和无溶剂条件下合成取代的吡嗪。该方法提供了一种在绿色条件下以优异的产率获得吡嗪衍生物的合成方法。