4-nitrophenyl undecanoate | 67513-12-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 4-nitrophenyl undecanoate
• 英文别名: (4-Nitrophenyl) undecanoate
• CAS: 67513-12-6
• 化学式: C₁₇H₂₅NO₄
• 分子量: 307.39
• InChiKey: XMCPMEHWNJBUAY-UHFFFAOYSA-N

物化性质

• 熔点：
  32-33 °C
• 沸点：
  419.4±28.0 °C(Predicted)
• 密度：
  1.069±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  22
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-nitrophenyl undecanoate 在 phosphate buffer pH 11.6 、 dimethyl-β-cyclodextrin 作用下， 以 水 为溶剂， 生成 对硝基苯酚 、 十一烷酸
  参考文献：
  名称：

  Tee, Oswald S.; Gadosy, Timothy A., Journal of the Chemical Society. Perkin transactions II, 1994, # 10, p. 2191 - 2198

  摘要：

  DOI：
• 作为产物：
  描述：

  对硝基苯酚 、 十一烷酰氯 在 吡啶 作用下， 以 甲苯 为溶剂， 反应 5.0h， 以79%的产率得到4-nitrophenyl undecanoate
  参考文献：
  名称：

  Cation-responsive silver-selective organogel—exploiting silver–alkene interactions in the gel-phase

  摘要：

  我们报告了一种对Ag+和Li+阳离子有响应但对Na+和K+阳离子无响应的凝胶剂，并证明银-烯烃相互作用在介导对Ag+的选择性凝胶-溶液响应中起着重要作用。

  DOI：

  10.1039/c2cc17854k

文献信息

• Generation and reaction of alkyl radicals in open reaction vessels
  作者：Elene Tatunashvili、Christopher S. P. McErlean

  DOI：10.1039/d0ob01892a

  日期：——

  alkyl iodides into reactive alkyl radicals is described. Aryl diazonium salts react with Hantzsch esters and molecular oxygen to give aryl radicals, which participate in halogen atom transfers to give alkyl radicals. These intermediates react with a variety of acceptors. The reaction cascade occurs at room temperature, in open reaction vessels, with short reaction times.

  描述了一种将烷基碘转化为反应性烷基自由基的操作简单的方法。芳基重氮盐与 Hantzsch 酯和分子氧反应生成芳基自由基，芳基自由基参与卤素原子转移生成烷基自由基。这些中间体与多种受体反应。反应级联发生在室温下，在开放的反应容器中，反应时间短。
• Tee, Oswald S.; Gadosy, Timothy A., Journal of the Chemical Society. Perkin transactions II, 1994, # 10, p. 2191 - 2198
  作者：Tee, Oswald S.、Gadosy, Timothy A.

  DOI：——

  日期：——
• Stereoselective Synthesis and Structure−Activity Relationship of Novel Ceramide Trafficking Inhibitors. (1<i>R</i>,3<i>R</i>)-<i>N</i>-(3-Hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide and Its Analogues
  作者：Yoshitaka Nakamura、Ryosuke Matsubara、Hidetoshi Kitagawa、Shū Kobayashi、Keigo Kumagai、Satoshi Yasuda、Kentaro Hanada

  DOI：10.1021/jm0300779

  日期：2003.8.1

  New ceramide trafficking inhibitors, (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamide (HPA-12) and a series of its analogues, were synthesized in diastereomerically and enantiomerically pure forms, and the structure-activity relationship was investigated. These analogues were stereoselectively synthesized via catalytic enantioselective Mannich-type reactions using a Cu(II)-chiral diamine 4 complex. Analysis of HPA-12 analogues having various lengths of the amide side chain showed that the optimal chain length for the inhibition of sphingomyelin biosynthesis is 13 with an IC50 of similar to50 nM. Masking of the hydroxy group at the 2'- or 3-position of HPA-12 was carried out by methylation, and it was revealed that these hydroxy groups were essential for the activity. Installation of another hydroxy group onto HPA-12 at the same position as that in the natural ceramide was also conducted, but no enhancement of the activity was observed.
• JIANG, XI-KUI;HUI, YONG-ZHENG;FAN, WEI-QIANG;WANG, SHU-JING, ACTA CHIM. SIN., 1985, 43, N 10, 983-987
  作者：JIANG, XI-KUI、HUI, YONG-ZHENG、FAN, WEI-QIANG、WANG, SHU-JING

  DOI：——

  日期：——
• [EN] BINDER FOR C-REACTIVE PROTEIN<br/>[FR] LIANT POUR PROTÉINE C-RÉACTIVE
  申请人：MODPRO AB

  公开号：WO2007117215A1

  公开（公告）日：2007-10-18

  [EN] The invention relates to a polypeptide dimer, wherein both protomers have a sequence according to SEQ ID NO: 1, wherein at least one phosphocholine derivative is attached to said polypeptide. Said polypeptide shows a specific binding for C-reactive protein (CRP). The invention further relates to use of the polypeptide in assays for determineing the concentration of CRP, purification of CRP and compositions comprising CRP.
  [FR] La présente invention concerne un dimère de polypeptide dans lequel les deux protomères présentent une séquence SEQ ID NO: 1, au moins un dérivé de phosphocholine étant relié audit polypeptide. Le polypeptide présente une liaison spécifique pour la protéine C-réactive (CRP). Cette invention concerne également l'utilisation dudit polypeptide dans le cadre de dosages pour déterminer la concentration en CRP, ainsi qu'un procédé de purification de CRP et des compositions comprenant CRP.