2-benzyloxy-5-(2'-benzyloxybenzyl)benzyl alcohol | 1254569-82-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-benzyloxy-5-(2'-benzyloxybenzyl)benzyl alcohol
• 英文别名: [2-Phenylmethoxy-5-[(2-phenylmethoxyphenyl)methyl]phenyl]methanol
• CAS: 1254569-82-8
• 化学式: C₂₈H₂₆O₃
• 分子量: 410.513
• InChiKey: KUNSYONCKSZGSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  夫拉美诺 、 2-benzyloxy-5-(2'-benzyloxybenzyl)benzyl alcohol 在 zinc(II) chloride 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 以34%的产率得到2-[2'-benzyloxy-5'-(2"-benzyloxybenzyl)benzyl]-5-methoxyresorcinol
  参考文献：
  名称：

  The first total synthesis of the natural product angoluvarin

  摘要：

  The total synthesis of angoluvarin, a member of the dihydrochalcone family of natural products, is reported. Starting with 2-bromophenol, the synthesis was accomplished in eight steps with an overall yield of 2%. This represents the first reported synthesis of angoluvarin. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.08.037
• 作为产物：
  描述：

  2-(benzyloxy)-5-(2-(benzyloxy)benzyl)benzaldehyde 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 28.0h， 以4.9 g的产率得到2-benzyloxy-5-(2'-benzyloxybenzyl)benzyl alcohol
  参考文献：
  名称：

  The first total synthesis of the natural product angoluvarin

  摘要：

  The total synthesis of angoluvarin, a member of the dihydrochalcone family of natural products, is reported. Starting with 2-bromophenol, the synthesis was accomplished in eight steps with an overall yield of 2%. This represents the first reported synthesis of angoluvarin. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.08.037

文献信息

• The first total synthesis of the natural product angoluvarin
  作者：Charles F. Nutaitis

  DOI：10.1016/j.tetlet.2010.08.037

  日期：2010.10

  The total synthesis of angoluvarin, a member of the dihydrochalcone family of natural products, is reported. Starting with 2-bromophenol, the synthesis was accomplished in eight steps with an overall yield of 2%. This represents the first reported synthesis of angoluvarin. (C) 2010 Elsevier Ltd. All rights reserved.