p-nitroethylbenzene hydroperoxide | 98487-93-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-nitroethylbenzene hydroperoxide
• 英文别名: α-methyl-p-nitrobenzyl hydroperoxide；1-(1-hydroperoxyethyl)-4-nitrobenzene
• CAS: 98487-93-5
• 化学式: C₈H₉NO₄
• 分子量: 183.164
• InChiKey: OXDCSSLJXARQTA-UHFFFAOYSA-N

物化性质

• 沸点：
  360.1±35.0 °C(Predicted)
• 密度：
  1.320±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  75.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  p-nitroethylbenzene hydroperoxide 在 sodium sulfite 作用下， 生成 对硝基苯乙醇
  参考文献：
  名称：

  硝基苄基衍生物的光-逆-羟醛型反应的结构和机理。碳-碳键的光化学异裂裂解

  摘要：

  光解 d'aryl-2 propanols-1 en phase aqueuse et en phase oxygenee; 分别获得甲苯、双苄和氢过氧苯。光逆醛醇化的机械练习曲

  DOI：

  10.1021/ja00221a038
• 作为产物：
  描述：

  对乙基硝基苯 在 氧气 、 溶剂红 43 作用下， 以 乙腈 为溶剂， 以72%的产率得到p-nitroethylbenzene hydroperoxide
  参考文献：
  名称：

  Benzylic Hydroperoxidation via Visible-Light-Induced Csp³–H Activation

  摘要：

  A highly efficient benzylic hydroperoxidation has been realized through a visible-light-induced Csp(3)-H activation. We believe that this reaction undergoes a direct HAT mechanism catalyzed by eosin Y. This approach features the use of a metal-free catalyst (eosin Y), an energy-economical light source (blue LED), and a sustainable oxidant (molecular oxygen). Primary, secondary, and tertiary hydroperoxides as well as silyl, benzyl, and acyl peroxides were successfully prepared with good yields and excellent functional group compatibility.

  DOI：

  10.1021/acs.joc.0c00385

文献信息

• Dirhodium(II) Complexes of 2-(Sulfonylimino)pyrrolidine: Synthesis and Application in Catalytic Benzylic Oxidation
  作者：Abudureheman Wusiman、Xiarepati Tusun、Chong-Dao Lu

  DOI：10.1002/ejoc.201200292

  日期：2012.6

  A new class of dirhodium(II) tetraamidinates derived from 2-(sulfonylimino)pyrrolidines has been prepared through ligand substitution by using dirhodium(II) acetate, in which (3,1) geometric isomers are formed predominantly. Among these complexes, (3,1)-Rh2(Msip)4, exhibits good catalytic performance in benzylic oxidation. In the presence of (3,1)-Rh2(Msip)4 a variety of benzylic derivatives, including

  使用乙酸二铑（II）通过配体取代制备了一类新的衍生自 2-（磺酰基亚氨基）吡咯烷的四脒二铑 (II)，其中主要形成 (3,1) 几何异构体。在这些配合物中，(3,1)-Rh2(Msip)4 在苄基氧化中表现出良好的催化性能。在 (3,1)-Rh2(Msip)4 存在下，多种苄基衍生物，包括强缺电子的芳基烷烃，如 1-乙基-4-硝基苯，在水中很容易被廉价的氧化剂 T-HYDRO 氧化。 R) (70 wt.-% 叔丁基氢过氧化物水溶液)。
• NEW CYCLIC PEPTIDE COMPOUNDS
  申请人：NEYA Masahiro

  公开号：US20100286033A1

  公开（公告）日：2010-11-11

  The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, to a process for preparation thereof comprising a rearrangement reaction under a mild acidic condition and the following amino acid changing reactions etc., to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.

  本发明涉及一种新的环肽化合物或其盐，其基于对丙型肝炎病毒复制体RNA复制的抑制活性具有抗丙型肝炎病毒活性，涉及制备该化合物的过程，包括在温和酸性条件下的重排反应及以下氨基酸改变反应等，涉及包含该化合物的制药组合物，以及涉及在人类或动物中预防和/或治疗丙型肝炎的方法。
• MAYTANSINOIDS AND THE USE OF SAID MAYTANSINOIDS TO PREPARE CONJUGATES WITH AN ANTIBODY
  申请人：BOUCHARD Hervé

  公开号：US20120276124A1

  公开（公告）日：2012-11-01

  The invention relates to a compound of formula (I): wherein: ALK is a (C 1 -C 6 )alkylene group; X 1 et X 2 are each independently one of the following groups: —CH═CH—, —CO—, —CONR—, —NRCO—, —COO—, —OCO—, —OCONR—, —NRCOO—, —NRCONR′—, —NR—, —S(O) n (n=0, 1 or 2) or —O—; R and R′ are independently H or a (C 1 -C 6 )alkyl group; i is an integer of from 1 to 40, preferably from 1 to 20, and more preferably from 1 to 10; j is an integer corresponding to 1 when X 2 is —CH═CH— and 2 when X 2 is not —CH═CH—; Z b is a simple bond, —O— or —NH— and R b is H or a (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, aryl, heteroaryl or (C 3 -C 7 )heterocycloalkyl group; or Z b is a single bond and R b is Hal.

  该发明涉及一种化合物，其化学式为(I)：其中：ALK是(C1-C6)烷基烯基链；X1和X2分别是以下基团之一：—CH═CH—，—CO—，—CONR—，—NRCO—，—COO—，—OCO—，—OCONR—，—NRCOO—，—NRCONR′—，—NR—，—S(O)n(n=0，1或2)或—O—；R和R′独立地为H或(C1-C6)烷基；i为1至40的整数，优选为1至20，更优选为1至10；j为1当X2为—CH═CH—时，为2当X2不为—CH═CH—时；Zb为单键，—O—或—NH—，Rb为H或(C1-C6)烷基，(C3-C7)环烷基，芳基，杂芳基或(C3-C7)杂环烷基；或Zb为单键，Rb为卤素。
• Cyclic Peptide Compounds
  申请人：Neya Masahiro

  公开号：US20090170755A1

  公开（公告）日：2009-07-02

  The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, to a process for preparation thereof comprising a rearrangement reaction under a mild acidic condition and the following amino acid changing reactions etc., to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.

  本发明涉及一种新的环肽化合物或其盐，其具有抗乙型肝炎病毒活性，基于其对乙型肝炎病毒复制体RNA复制的抑制活性，以及一种制备该化合物的过程，包括在温和酸性条件下进行的重排反应和以下氨基酸变化反应等，还涉及到包含该化合物的制药组合物，以及在人类或动物中预防和/或治疗乙型肝炎的方法。
• Bukharkina, T. V.; Shelud'ko, A. B.; Digurov, N. G., Journal of applied chemistry of the USSR, 1989, vol. 62, # 7.2, p. 1473 - 1477
  作者：Bukharkina, T. V.、Shelud'ko, A. B.、Digurov, N. G.

  DOI：——

  日期：——