1-Methoxy-4-[4-[(4-methoxyphenyl)methoxy]butoxymethyl]benzene | 1394138-35-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Methoxy-4-[4-[(4-methoxyphenyl)methoxy]butoxymethyl]benzene
• 英文别名: 1-methoxy-4-[4-[(4-methoxyphenyl)methoxy]butoxymethyl]benzene
• CAS: 1394138-35-2
• 化学式: C₂₀H₂₆O₄
• 分子量: 330.424
• InChiKey: RSHPNYGFABELPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,4-丁二醇 、 4-甲氧基苄醇 在 Amberlyst-15 作用下， 以 二氯甲烷 为溶剂， 反应 9.5h， 以70%的产率得到1-Methoxy-4-[4-[(4-methoxyphenyl)methoxy]butoxymethyl]benzene
  参考文献：
  名称：

  A very practical and selective method for PMB protection of alcohols

  摘要：

  A very simple, practical and efficient one-step heterogeneous protocol for the PMB protection of alcohols using Amberlyst-15 has been developed. The stability and hazard issues regarding PMBCI and PMBBr are totally avoided by directly using anisyl alcohol for the protection. Alcohols are protected in very good yields. The selective mono-PMB protection of diols as well as di-PMB protection of diols was achieved in good yields, along with the demonstration of recyclability of the catalyst. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.06.084

文献信息

• A very practical and selective method for PMB protection of alcohols
  作者：Subhash P. Chavan、Kishor R. Harale

  DOI：10.1016/j.tetlet.2012.06.084

  日期：2012.8

  A very simple, practical and efficient one-step heterogeneous protocol for the PMB protection of alcohols using Amberlyst-15 has been developed. The stability and hazard issues regarding PMBCI and PMBBr are totally avoided by directly using anisyl alcohol for the protection. Alcohols are protected in very good yields. The selective mono-PMB protection of diols as well as di-PMB protection of diols was achieved in good yields, along with the demonstration of recyclability of the catalyst. (c) 2012 Elsevier Ltd. All rights reserved.