4-Methyl-2-pentyltosylat | 25012-58-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Methyl-2-pentyltosylat
• 英文别名: 4-Methylpentan-2-yl 4-methylbenzene-1-sulfonate；4-methylpentan-2-yl 4-methylbenzenesulfonate
• CAS: 25012-58-2
• 化学式: C₁₃H₂₀O₃S
• 分子量: 256.366
• InChiKey: RCBALZFUBNAJMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  频哪醇 、 4-Methyl-2-pentyltosylat 在 双联邻苯二酚硼酸酯 、 potassium iodide 、 三乙胺 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 以81 %的产率得到2,2'-(4-methylpentane-2,3-diyl)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane)
  参考文献：
  名称：

  烷基卤化物、甲苯磺酸盐和醇的选择性、无过渡金属 1,2-二硼化

  摘要：

  开发了一种无过渡金属、简单且有效的策略，通过对容易获得的仲和叔烷基卤化物（Br、Cl、I）、甲苯磺酸酯和醇进行区域和非对映选择性二硼化来获得烷基 1,2-双（硼酸酯） 。 KI 和 DMA 的使用对该方法至关重要，它可以避免区域选择性和非对映选择性问题。该转化显示了广泛的底物范围（75 个实例）以及天然产物后期修饰的实用性。

  DOI：

  10.1002/chem.202200480
• 作为产物：
  描述：

  4-甲基-2-戊酮 在 sodium tetrahydroborate 、 三甲胺盐酸盐 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 4-Methyl-2-pentyltosylat
  参考文献：
  名称：

  烷基卤化物、甲苯磺酸盐和醇的选择性、无过渡金属 1,2-二硼化

  摘要：

  开发了一种无过渡金属、简单且有效的策略，通过对容易获得的仲和叔烷基卤化物（Br、Cl、I）、甲苯磺酸酯和醇进行区域和非对映选择性二硼化来获得烷基 1,2-双（硼酸酯） 。 KI 和 DMA 的使用对该方法至关重要，它可以避免区域选择性和非对映选择性问题。该转化显示了广泛的底物范围（75 个实例）以及天然产物后期修饰的实用性。

  DOI：

  10.1002/chem.202200480

文献信息

• Laser markable compositions, articles and documents
  申请人：AGFA-GEVAERT

  公开号：US10286708B2

  公开（公告）日：2019-05-14

  A laser markable composition includes (a) an aqueous medium; (b) capsules composed of a polymeric shell surrounding a core; (c) a color developing agent or color developing agent precursor; and (d) an optothermal converting agent; characterized in that the core of the capsule contains a leuco dye.

  一种可激光打标组合物包括：(a) 一种水介质；(b) 由围绕核心的聚合物外壳组成的胶囊；(c) 一种显色剂或显色剂前体；(d) 一种光热转换剂；其特征在于，胶囊的核心含有一种白兰地染料。
• Detailed Characterization of <i>p</i>-Toluenesulfonic Acid Monohydrate as a Convenient, Recoverable, Safe, and Selective Catalyst for Alkylation of the Aromatic Nucleus
  作者：Mathew P. D. Mahindaratne、Kandatege Wimalasena

  DOI：10.1021/jo971832r

  日期：1998.5.1

  Alkylation of the aromatic nucleus, an important reaction in industry and synthetic organic chemistry, has traditionally been carried out by the well-known Friedel-Crafts reaction employing Lewis acid catalysts such as AlCl3 and BF3 or by using highly reactive organometallic reagents. Although protic acids such as anhydrous HF and concentrated H2SO4 have also been used in the alkylation of the aromatic nucleus, the notoriously corrosive, highly toxic, and hazardous nature of these agents has precluded their common use under ordinary laboratory conditions. Various organic sulfonic acids have, on occasion, been used as catalysts in Friedel-Crafts alkylations, but to our knowledge the chemistry and the scope of these reactions for common laboratory use have never been exploited in detail. In the present study we have characterized commercially available p-toluenesulfonic acid monohydrate (TsOH) as an efficient catalyst for the intermolecular coupling of the aromatic nucleus with activated alkyl halides, alkenes, or tosylates under mild conditions in an open atmosphere. In comparison to conventional Friedel-Crafts catalysts such as AlCl3, BF3, HF, and concentrated H2SO4, the extent of the formation of undesired products from side reactions such as transalkylation, polymerization, etc. was minimal with the TsOH-catalyzed reaction. The ability to recover and reuse the catalyst from the reaction mixtures, minimal generation of environmentally unfriendly waste, high specificity of the reaction, and the low cost of the catalyst are important advantages of the TsOH catalyst over the other conventional Friedel-Crafts catalysts.
• Mechanisms of elimination reactions. XVIII. The effect of base, solvent, and structure on product ratios in E2 reactions of some sulfonium salts
  作者：Irving N. Feit、Frank Schadt、Jacek Lubinkowski、William H. Saunders

  DOI：10.1021/ja00753a046

  日期：1971.12
• LASER MARKABLE COMPOSITIONS, ARTICLES AND DOCUMENTS
  申请人：AGFA-GEVAERT

  公开号：US20180154667A1

  公开（公告）日：2018-06-07

  A laser markable composition includes (a) an aqueous medium; (b) capsules composed of a polymeric shell surrounding a core; (c) a colour developing agent or colour developing agent precursor; and (d) an optothermal converting agent; characterized in that the core of the capsule contains a leuco dye.
• PROCESS FOR MANUFACTURING A LASER MARKABLE PACKAGING
  申请人：AGFA NV

  公开号：US20190232699A1

  公开（公告）日：2019-08-01

  An offset printing process for manufacturing a laser markable packaging uses a laser markable offset ink and a laser markable varnish or a laser markable dispersion-lacquer in the process to provide a laser markable image or area on the packaging. The laser markable offset ink, offset varnish or offset dispersion-lacquer including a leuco dye and a metal free optothermal converting agent may be used in the offset printing process.