2-amino-6-isobutyl-4-(4-methoxyphenyl)nicotinonitrile | 74873-36-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-amino-6-isobutyl-4-(4-methoxyphenyl)nicotinonitrile
• 英文别名: 2-amino-4-(4-methoxyphenyl)-6-(2-methylpropyl)pyridine-3-carbonitrile
• CAS: 74873-36-2
• 化学式: C₁₇H₁₉N₃O
• 分子量: 281.357
• InChiKey: ZVTQDDAZRUJCQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  71.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (4-甲氧基苄烯)丙二腈 、 4-甲基-2-戊酮 在 ammonium acetate 作用下， 以 苯 为溶剂， 反应 3.0h， 以39%的产率得到2-amino-6-isobutyl-4-(4-methoxyphenyl)nicotinonitrile
  参考文献：
  名称：

  A Simple Method for the Preparation of 2-Amino-4-aryl-3-cyanopyridines by the Condensation of Malononitrile with Aromatic Aldehydes and Alkyl Ketones in the Presence of Ammonium Acetate

  摘要：

  DOI：

  10.1055/s-1980-29021

文献信息

• Method of using aminocyanopyridine compounds as mitogen activated protein kinase-activated protein kinase-2 inhibitors
  申请人：Pharmacia Corporation

  公开号：US20040127519A1

  公开（公告）日：2004-07-01

  A method is described for inhibiting mitogen activated protein kinase-activated protein kinase-2 in a subject in need of such inhibition, where the method involves administering to the subject an anminocyanopyridine MK-2 inhibiting compound, or a pharmaceutically acceptable salt thereof.

  本文描述了一种抑制需要抑制的受试者中的有丝分裂原活化蛋白激酶激活蛋白激酶-2的方法，其中该方法涉及向受试者给予一种抑制MK-2的氨基氰基吡啶化合物或其药学上可接受的盐。
• Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase-2
  申请人：Pharmacia Corporation

  公开号：US20040142978A1

  公开（公告）日：2004-07-22

  Aminocyanopyridine compounds are described which can inhibit mitogen activated protein kinase-activated protein kinase-2. Pharmaceutical compositions and kits that contain these compounds are also described.

  描述了可抑制丝裂原活化蛋白激酶-活化蛋白激酶-2 的氨基氰吡啶化合物。还描述了含有这些化合物的药物组合物和试剂盒。
• One-pot synthesis of 2-amino-3-cyanopyridine derivatives catalyzed by ytterbium perfluorooctanoate [Yb(PFO)3]
  作者：Jun Tang、Limin Wang、Yinfang Yao、Liang Zhang、Wenbo Wang

  DOI：10.1016/j.tetlet.2010.11.102

  日期：2011.1

  A family of 2-amino-3-cyanopyridine derivatives are synthesized from aldehydes, ketones, malononitrile, and ammonium acetate via one-pot reaction catalyzed by ytterbium perfluorooctanoate [Yb(PFO)(3)]. This procedure tolerates most of substrates and has the advantages of short routine, high yields, and environmentally friendly. Furthermore, the possible mechanism is also proposed. (C) 2010 Elsevier Ltd. All rights reserved.
• METHOD OF USING AMINOCYANOPYRIDINE COMPOUNDS AS MITOGEN ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITORS
  申请人：Pharmacia Corporation

  公开号：EP1569645A2

  公开（公告）日：2005-09-07
• AMINOCYANOPYRIDINE INHIBITORS OF MITOGEN ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2
  申请人：Pharmacia Corporation

  公开号：EP1569932A1

  公开（公告）日：2005-09-07