5-ethyl-4'-fluoro-2-(methylthio)benzophenone | 69738-07-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-ethyl-4'-fluoro-2-(methylthio)benzophenone
• 英文别名: (5-Ethyl-2-methylsulfanylphenyl)-(4-fluorophenyl)methanone
• CAS: 69738-07-4
• 化学式: C₁₆H₁₅FOS
• 分子量: 274.359
• InChiKey: LHGRASJKRYPEDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-ethyl-4'-fluoro-2-(methylthio)benzophenone 在 双氧水 作用下， 以 溶剂黄146 为溶剂， 反应 1.0h， 以27.5%的产率得到5-Ethyl-4'-fluoro-2-(methylsulphinyl)benzophenone
  参考文献：
  名称：

  Antianaphylactic benzophenones and related compounds

  摘要：

  The synthesis and biological properties of 85 benzophenones and related compounds are described. The majority of the compounds inhibit the release of leukotrienes (LT) C4 and D4 in vitro from sensitized guinea pig chopped lung. In addition, some of the compounds inhibited the release of LTs from passively sensitized human chopped lung and protected guinea pigs from the effects of anaphylaxis in a modified Herxheimer test.

  DOI：

  10.1021/jm00391a010

文献信息

• Benzophenone derivatives
  申请人：Eli Lilly and Company

  公开号：US04134993A1

  公开（公告）日：1979-01-16

  Novel benzophenone derivatives having anti-allergy activity, and pharmaceutical formulations and methods of treatment utilizing benzophenone derivatives.

  具有抗过敏活性的新型苯甲酮衍生物，以及利用苯甲酮衍生物的制药配方和治疗方法。
• EVANS, DELME;CRACKNELL, MARK E.;SAUNDERS, JOHN C.;SMITH, CHRISTINE E.;WIL+, J. MED. CHEM., 30,(1987) N 8, 1321-1327
  作者：EVANS, DELME、CRACKNELL, MARK E.、SAUNDERS, JOHN C.、SMITH, CHRISTINE E.、WIL+

  DOI：——

  日期：——
• US4134993A
  申请人：——

  公开号：US4134993A

  公开（公告）日：1979-01-16
• Antianaphylactic benzophenones and related compounds
  作者：Delme Evans、Mark E. Cracknell、John C. Saunders、Christine E. Smith、W. R. Nigel Williamson、William Dawson、W. John F. Sweatman

  DOI：10.1021/jm00391a010

  日期：1987.8

  The synthesis and biological properties of 85 benzophenones and related compounds are described. The majority of the compounds inhibit the release of leukotrienes (LT) C4 and D4 in vitro from sensitized guinea pig chopped lung. In addition, some of the compounds inhibited the release of LTs from passively sensitized human chopped lung and protected guinea pigs from the effects of anaphylaxis in a modified Herxheimer test.