5'-chloro-4-hydroxy-2’-methoxy-[1,1'-biphenyl]-3-carboxylic acid | 1267039-51-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5'-chloro-4-hydroxy-2’-methoxy-[1,1'-biphenyl]-3-carboxylic acid
• 英文别名: 5'-chloro-4-hydroxy-2'-methoxy-biphenyl-3-carboxylic acid；5'-Chloro-4-hydroxy-2'-methoxybiphenyl-3-carboxylic acid；5-(5-chloro-2-methoxyphenyl)-2-hydroxybenzoic acid
• CAS: 1267039-51-9
• 化学式: C₁₄H₁₁ClO₄
• mdl: MFCD19341968
• 分子量: 278.692
• InChiKey: JOSDFDUFCGZDKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.071
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-碘水杨酸 、 5-氯-2-甲氧基苯硼酸 在 palladium diacetate 、 sodium carbonate 作用下， 以 水 为溶剂， 以74%的产率得到5'-chloro-4-hydroxy-2’-methoxy-[1,1'-biphenyl]-3-carboxylic acid
  参考文献：
  名称：

  Tuning Transthyretin Amyloidosis Inhibition Properties of Iododiflunisal by Combinatorial Engineering of the Nonsalicylic Ring Substitutions

  摘要：

  Two series of iododiflunisal and diflunisal analogues have been obtained by using a two step sequential reaction solution-phase parallel synthesis. The synthesis combined an aqueous Suzuki-Miyaura cross-coupling and a mild electrophilic aromatic iodination step using a new polymer-supported iodonium version of Barluenga's reagent. From a selected set of 77 noniodinated and 77 iodinated diflunisal analogues, a subset of good transthyretin amyloid inhibitors has been obtained with improved turbidimetry inhibition constants, high binding affinity to transthyretin, and good selectivity for TTR compared to other thyroxine binding proteins.

  DOI：

  10.1021/co5001234

文献信息

• Thrombopoietin mimetics
  申请人：——

  公开号：US20040019190A1

  公开（公告）日：2004-01-29

  Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy- 1 -azobenzene derivative.

  发明了非肽类TPO类似物。还发明了用于制备目前发明的化合物的新工艺和中间体。还发明了一种治疗血小板减少症的方法，包括给予需要的哺乳动物，包括人类，有效量的选择性羟基-1-偶氮苯衍生物。
• THROMBOPOIETIN MIMETICS
  申请人：Duffy Kevin J.

  公开号：US20090155203A1

  公开（公告）日：2009-06-18

  Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

  发明了非肽类TPO类似物。还发明了用于制备当前发明化合物的新型过程和中间体。还发明了一种治疗血小板减少症的方法，包括在需要的哺乳动物（包括人类）中给予所述哺乳动物有效量的选择性羟基-1-偶氮苯衍生物。
• US7160870B2
  申请人：——

  公开号：US7160870B2

  公开（公告）日：2007-01-09
• US7332481B2
  申请人：——

  公开号：US7332481B2

  公开（公告）日：2008-02-19
• US7335649B2
  申请人：——

  公开号：US7335649B2

  公开（公告）日：2008-02-26