2,2'-bis[(4'S)-(diethylhydroxymethyl)oxazolin-2'-yl]-1,1'-biphenyl | 278595-76-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-bis[(4'S)-(diethylhydroxymethyl)oxazolin-2'-yl]-1,1'-biphenyl
• 英文别名: 3-[(4S)-2-[2-[2-[(4S)-4-(3-hydroxypentan-3-yl)-4,5-dihydro-1,3-oxazol-2-yl]phenyl]phenyl]-4,5-dihydro-1,3-oxazol-4-yl]pentan-3-ol
• CAS: 278595-76-9
• 化学式: C₂₈H₃₆N₂O₄
• 分子量: 464.605
• InChiKey: KTTKCLKPDVQXJS-ZEQRLZLVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,2'-bis[(4'S)-(diethylhydroxymethyl)oxazolin-2'-yl]-1,1'-biphenyl 、 碘甲烷 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 以51%的产率得到2,2'-bis[(4'S)-(diethylmethoxymethyl)oxazolin-2'-yl]-1,1'-biphenyl
  参考文献：
  名称：

  Bisoxazoline ligands with an axial-unfixed biaryl backbone: the effects of the biaryl backbone and the substituent at oxazoline ring on Cu-catalyzed asymmetric cyclopropanation

  摘要：

  The synthesis of novel C-symmetric bisoxazoline ligands with an axial-unfixed biaryl backbone and different substituents at the oxazoline ring is reported. The diastcreomer equilibrium of these ligands in solution and their complexation behavior with the copper(I) ion were Studied. Their application in Cu-catalyzed cyclopropanation of styrene, with diazoacetate, was carried out and the effects of the biaryl backbone and the substituent on the oxazoline ring in the catalysis were examined. The best result was obtained with the ligand having a 1,1'-binaphthyl backbone and a t-butyl group on the oxazoline ring, which afforded 89% de and 96% de for the trans- and cis-products of the above asymmetric cyclopropanation reaction, respectively. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.02.014
• 作为产物：
  描述：

  2,2'-biphenyldicarboxylic acid dichloride 在 methoxycarbonylsulfamoyl-triethylammmonium hydroxide 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 2,2'-bis[(4'S)-(diethylhydroxymethyl)oxazolin-2'-yl]-1,1'-biphenyl
  参考文献：
  名称：

  Bisoxazoline ligands with an axial-unfixed biaryl backbone: the effects of the biaryl backbone and the substituent at oxazoline ring on Cu-catalyzed asymmetric cyclopropanation

  摘要：

  The synthesis of novel C-symmetric bisoxazoline ligands with an axial-unfixed biaryl backbone and different substituents at the oxazoline ring is reported. The diastcreomer equilibrium of these ligands in solution and their complexation behavior with the copper(I) ion were Studied. Their application in Cu-catalyzed cyclopropanation of styrene, with diazoacetate, was carried out and the effects of the biaryl backbone and the substituent on the oxazoline ring in the catalysis were examined. The best result was obtained with the ligand having a 1,1'-binaphthyl backbone and a t-butyl group on the oxazoline ring, which afforded 89% de and 96% de for the trans- and cis-products of the above asymmetric cyclopropanation reaction, respectively. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.02.014

文献信息

• Bisoxazoline ligands with an axial-unfixed biaryl backbone: the effects of the biaryl backbone and the substituent at oxazoline ring on Cu-catalyzed asymmetric cyclopropanation
  作者：Wanbin Zhang、Fang Xie、Shigeaki Matsuo、Yuji Imahori、Toshiyuki Kida、Yohji Nakatsuji、Isao Ikeda

  DOI：10.1016/j.tetasy.2006.02.014

  日期：2006.3

  The synthesis of novel C-symmetric bisoxazoline ligands with an axial-unfixed biaryl backbone and different substituents at the oxazoline ring is reported. The diastcreomer equilibrium of these ligands in solution and their complexation behavior with the copper(I) ion were Studied. Their application in Cu-catalyzed cyclopropanation of styrene, with diazoacetate, was carried out and the effects of the biaryl backbone and the substituent on the oxazoline ring in the catalysis were examined. The best result was obtained with the ligand having a 1,1'-binaphthyl backbone and a t-butyl group on the oxazoline ring, which afforded 89% de and 96% de for the trans- and cis-products of the above asymmetric cyclopropanation reaction, respectively. (c) 2006 Elsevier Ltd. All rights reserved.