(E)-2-methoxyiminomethyl phenoxyacetic acid | 162509-31-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-2-methoxyiminomethyl phenoxyacetic acid
• 英文别名: (E)-(2-methoxyiminomethylphenoxy)acetic acid；2-methoxyiminomethyl phenoxyacetic acid；2-[2-[(E)-methoxyiminomethyl]phenoxy]acetic acid
• CAS: 162509-31-1
• 化学式: C₁₀H₁₁NO₄
• 分子量: 209.202
• InChiKey: MBRQALIJBRICNH-IZZDOVSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  68.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (E)-2-methoxyiminomethyl phenoxyacetic acid 在 N-甲基吗啉 、 水 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 (6R,7R)-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-7-[[2-[2-[(E)-methoxyiminomethyl]phenoxy]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  参考文献：
  名称：

  Synthesis and activity of cephalosporins containing an oxyiminomethylene functionality in the ortho-position of a phenyl- or phenoxyacetic acid C-7 side chain substituent

  摘要：

  A new series of cephalosporins having in the C-7 side chain a phenyl- or a phenoxyacetamido group bearing an oxyiminomethyl function in the ortho-position of the aromatic ring was prepared. Their in vitro activity was tested against both Gram+ and Gram- strains. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(98)00112-8
• 作为产物：
  描述：

  在 sodium hydroxide 、 四丁基溴化铵 、 水 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 (E)-2-methoxyiminomethyl phenoxyacetic acid
  参考文献：
  名称：

  Synthesis and activity of cephalosporins containing an oxyiminomethylene functionality in the ortho-position of a phenyl- or phenoxyacetic acid C-7 side chain substituent

  摘要：

  A new series of cephalosporins having in the C-7 side chain a phenyl- or a phenoxyacetamido group bearing an oxyiminomethyl function in the ortho-position of the aromatic ring was prepared. Their in vitro activity was tested against both Gram+ and Gram- strains. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(98)00112-8

文献信息

• Oxime derivatives of cephalosporanic structure
  申请人：ACS Dobfar S.p.A.

  公开号：US05574153A1

  公开（公告）日：1996-11-12

  The invention relates to oxime derivatives of cephalosporanic structure, possessing antibacterial activity.

  这项发明涉及头孢菌素结构的肟衍生物，具有抗菌活性。
• Synthesis and activity of cephalosporins containing an oxyiminomethylene functionality in the ortho-position of a phenyl- or phenoxyacetic acid C-7 side chain substituent
  作者：Domenico Albanese、Dario Landini、Mario Leone、Michele Penso、Maurizio Zenoni

  DOI：10.1016/s0014-827x(98)00112-8

  日期：1998.11

  A new series of cephalosporins having in the C-7 side chain a phenyl- or a phenoxyacetamido group bearing an oxyiminomethyl function in the ortho-position of the aromatic ring was prepared. Their in vitro activity was tested against both Gram+ and Gram- strains. (C) 1998 Elsevier Science S.A. All rights reserved.