2-氨基-N-[2-(2-甲氧基苯基)乙基]苯甲酰胺 | 527690-05-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氨基-N-[2-(2-甲氧基苯基)乙基]苯甲酰胺
• 英文名称: 2-amino-N-[2-(2-methoxyphenyl)ethyl]benzamide
• CAS: 527690-05-7
• 化学式: C₁₆H₁₈N₂O₂
• mdl: MFCD03552730
• 分子量: 270.331
• InChiKey: QGPNQXLPXOTLSH-UHFFFAOYSA-N

物化性质

• 沸点：
  490.7±35.0 °C(Predicted)
• 密度：
  1.158±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  2-氨基-N-[2-(2-甲氧基苯基)乙基]苯甲酰胺 在 1,1,2,3-四甲基胍 作用下， 以 二氯甲烷 、 氯仿 为溶剂， 生成 1-methyl-3-[2'-(2'-methoxyphenyl)ethyl]-1H-quinazoline-2,4-dione
  参考文献：
  名称：

  Syntheses of Quinazoline-2,4-dione Alkaloids and Analogues from Mexican Zanthoxylum Species †

  摘要：

  喹唑啉酮和喹唑啉二酮衍生物因其广泛的药理性质而受到广泛关注。在本文中，我们报告了十种喹唑啉二酮的合成。此前已经报道了其中两个化合物，即1-甲基-3-(2'-苯乙基)-1H,3H-喹唑啉-2,4-二酮和1-甲基-3-[2'-(4'-甲氧基苯基)乙基]-1H,3H-喹唑啉-2,4-二酮，来自墨西哥刺柠檬种子的种皮。

  DOI：

  10.3390/90700609
• 作为产物：
  描述：

  靛红酸酐 、 2-甲氧基苯乙胺 以 N,N-二甲基甲酰胺 为溶剂， 以92%的产率得到2-氨基-N-[2-(2-甲氧基苯基)乙基]苯甲酰胺
  参考文献：
  名称：

  Syntheses of Quinazoline-2,4-dione Alkaloids and Analogues from Mexican Zanthoxylum Species †

  摘要：

  喹唑啉酮和喹唑啉二酮衍生物因其广泛的药理性质而受到广泛关注。在本文中，我们报告了十种喹唑啉二酮的合成。此前已经报道了其中两个化合物，即1-甲基-3-(2'-苯乙基)-1H,3H-喹唑啉-2,4-二酮和1-甲基-3-[2'-(4'-甲氧基苯基)乙基]-1H,3H-喹唑啉-2,4-二酮，来自墨西哥刺柠檬种子的种皮。

  DOI：

  10.3390/90700609

文献信息

• Convenient and sequential one-pot route for synthesis of 2-thioxoquinazolinone and quinazolinobenzothiazinedione derivatives
  作者：Mehdi Asadi、Shiva Masoomi、Seyed Mostafa Ebrahimi、Mohammad Mahdavi、Mina Saeedi、Abbas Shafiee、Alireza Foroumadi

  DOI：10.1007/s00706-013-1110-8

  日期：2014.3

  AbstractA new and efficient synthetic process has been developed for preparation of 2-thioxoquinazolinone and quinazolinobenzothiazinedione derivatives. The related products were synthesized through reaction of isatoic anhydride, amines/anthranilic acids, and carbon disulfide (CS2) in the presence of potassium hydroxide in ethanol at reflux. Graphical abstract

  摘要已经开发出一种新的有效的合成方法来制备2-硫代氧杂喹唑啉酮和喹唑啉基苯并噻嗪二酮衍生物。在乙醇中，在氢氧化钾存在下，通过等角酸酐，胺/邻氨基苯甲酸和二硫化碳（CS 2）反应合成相关产物。 图形概要
• Green Synthesis of New Boron-Containing Quinazolines: Preparation of Benzo[<i>d</i>][1,3,2]diazaborinin-4(1<i>H</i>)-one Derivatives
  作者：Mohammad Mahdavi、Mehdi Asadi、Mina Saeedi、Maryam Hosseinpour Tehrani、Seyedeh Sara Mirfazli、Abbas Shafiee、Alireza Foroumadi

  DOI：10.1080/00397911.2012.751612

  日期：2013.11.2

  A series of new boron-containing quinazolinones, benzo[d][1,3,2]diazaborinin-4(1H)-one derivatives, were synthesized by the sequential one-pot reaction of isatoic anhydride, amines, and arylboronic acids in the absence of a catalyst and solvent. Heating isotoic anhydride and amines led to the formation of 2-aminobenzamide intermediates, which reacted easily with boronic acids to obtain the title compounds in good yields. Solvent-free conditions provided a unique procedure because the corresponding products were not obtained using various solvents either under reflux conditions or at room temperature. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource: Full experimental and spectral details.]
• Vilsmeier Reagent: An Efficient Reagent for the Transformation of 2-Aminobenzamides into Quinazolin-4(3<i>H</i>)-one Derivatives
  作者：Soghra Farzipour、Mina Saeedi、Mohammad Mahdavi、Hossein Yavari、Mohammadreza Mirzahekmati、Nasser Ghaemi、Alireza Foroumadi、Abbas Shafiee

  DOI：10.1080/00397911.2013.811528

  日期：2014.2.16

  Clean and easy preparation of quinazolin-4(3H)-one derivatives using 2-aminobenzamides and Vilsmeier reagent is described. 2-Aminobenzamides were converted into the corresponding quinazolinones under mild and efficient conditions, in good yields without undesirable by-products. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]