ethyl-(3-bromo-4-methoxy-benzyl)-amine | 22704-61-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl-(3-bromo-4-methoxy-benzyl)-amine
• 英文别名: 3-Brom-α-aethylamino-4-methoxy-toluol；Aethyl-(3-brom-4-methoxy-benzyl)-amin；N-[(3-bromo-4-methoxyphenyl)methyl]ethanamine
• CAS: 22704-61-6
• 化学式: C₁₀H₁₄BrNO
• mdl: MFCD09965829
• 分子量: 244.131
• InChiKey: XPVSMXFCFRMCPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  ethyl-(3-bromo-4-methoxy-benzyl)-amine 、 丙烯酸甲酯（MA） 在 苯 作用下， 生成 N-ethyl-N-(3-bromo-4-methoxy-benzyl)-β-alanine methyl ester
  参考文献：
  名称：

  Synthetic Analogs of Oxytocic Drugs. III. Homologs of the Phenethyl β-Alanine Type

  摘要：

  DOI：

  10.1021/ja01178a046
• 作为产物：
  描述：

  N-乙基-4-甲氧基苄胺 生成 ethyl-(3-bromo-4-methoxy-benzyl)-amine
  参考文献：
  名称：

  Synthetic Analogs of Oxytocic Drugs. III. Homologs of the Phenethyl β-Alanine Type

  摘要：

  DOI：

  10.1021/ja01178a046

文献信息

• [EN] MACROCYCLIC UREA OREXIN RECEPTOR AGONISTS<br/>[FR] AGONISTES DU RÉCEPTEUR DE L'OREXINE D'URÉE MACROCYCLIQUE
  申请人：MERCK SHARP & DOHME

  公开号：WO2022094012A1

  公开（公告）日：2022-05-05

  The present invention is directed to macrocyclic urea compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及宏环脲化合物，其是睡觉醒来素受体的激动剂。本发明还涉及所述化合物在潜在的涉及睡觉醒来素受体的神经和精神障碍和疾病的治疗或预防中的用途。本发明还涉及包含这些化合物的组合物。本发明还涉及这些组合物在潜在涉及睡觉醒来素受体的这些疾病的预防或治疗中的用途。
• [EN] UREA OREXIN RECEPTOR AGONISTS<br/>[FR] AGONISTES DU RÉCEPTEUR DE L'OREXINE D'URÉE
  申请人：MERCK SHARP & DOHME

  公开号：WO2022132696A1

  公开（公告）日：2022-06-23

  The present invention is directed to urea compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及尿素化合物，其为促进荷尔蒙受体的激动剂。本发明还涉及所述化合物在潜在治疗或预防神经系统和精神疾病中的应用，其中荷尔蒙受体参与其中。本发明还涉及包含这些化合物的组合物。本发明还涉及这些组合物在潜在预防或治疗荷尔蒙受体参与的疾病中的应用。
• Synthetic Analogs of Oxytocic Drugs. III. Homologs of the Phenethyl β-Alanine Type
  作者：Richard. Baltzly、Arthur P. Phillips

  DOI：10.1021/ja01178a046

  日期：1949.10