3-methyl-4-(3-nitrophenyl)indeno[1,2-b]pyrazolo-[4,3-e]pyridin-5(1H)-one | 1260635-09-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-methyl-4-(3-nitrophenyl)indeno[1,2-b]pyrazolo-[4,3-e]pyridin-5(1H)-one
• 英文别名: 3-methyl-4-(3-nitrophenyl)indeno[1,2-b]pyrazolo[4,3-e]pyridin-5(1H)-one；12-methyl-10-(3-nitrophenyl)-13,14,16-triazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-one
• CAS: 1260635-09-3
• 化学式: C₂₀H₁₂N₄O₃
• 分子量: 356.34
• InChiKey: PSOAPNUABWULAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-氨基-5-甲基吡唑 、 1,3-茚满二酮 、 3-硝基苯甲醇 在 aluminum hydrogen sulfate 作用下， 反应 0.07h， 以94%的产率得到3-methyl-4-(3-nitrophenyl)indeno[1,2-b]pyrazolo-[4,3-e]pyridin-5(1H)-one
  参考文献：
  名称：

  Aluminum hydrogen sulfate as a green catalyst for the solvent-free synthesis of pyrazolopyridines

  摘要：

  Aluminum hydrogen sulfate turned out to be a mild, convenient, and efficient reagent for the conversion of substituted benzyl alcohols into pyrazolopyridines via condensation with 3-methyl-1H-pyrazole-5-amine and CH acid (malononitrile or indan-1,3-dione) at room temperature under solvent-free conditions with high yield, high purity, and short reaction time.

  DOI：

  10.1134/s1070363215050308

文献信息

• An efficient and clean synthesis of indeno[1,2-b]pyrazolo[4,3-e] pyridin-5(1H)-one derivatives under microwave irradiation in water
  作者：Shuliang Wang、Ning Ma、Ge Zhang、Feng Shi、Bo Jiang、Han Lu、Yuan Gao、Shujiang Tu

  DOI：10.1002/jhet.468

  日期：2010.11

  A series of new indeno[1,2‐b]pyrazolo[4,3‐e]pyridin‐5(1H)‐one derivatives were synthesized by three‐component reactions of 1,3‐indandione, 3‐methyl‐1H‐pyrazol‐5‐amine, and aldehyde in water under microwave irradiation without any catalyst. J. Heterocyclic Chem., (2010).

  通过1,3-茚满二酮，3-甲基-1 H的三组分反应合成了一系列新的茚并[1,2- b ]吡唑并[4,3 - e ]吡啶5-5 （1 H）-one衍生物在没有任何催化剂的微波辐射下，水中的吡唑-5胺和醛。J.杂环化​​学。（2010）。
• Aluminum hydrogen sulfate as a green catalyst for the solvent-free synthesis of pyrazolopyridines
  作者：M. Nikpassand、L. Zare Fekri

  DOI：10.1134/s1070363215050308

  日期：2015.5

  Aluminum hydrogen sulfate turned out to be a mild, convenient, and efficient reagent for the conversion of substituted benzyl alcohols into pyrazolopyridines via condensation with 3-methyl-1H-pyrazole-5-amine and CH acid (malononitrile or indan-1,3-dione) at room temperature under solvent-free conditions with high yield, high purity, and short reaction time.